3KLI
Crystal structure of unliganded AZT-resistant HIV-1 Reverse Transcriptase
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Reverse transcriptase/ribonuclease H | polymer | 562 | 64762.3 | 1 | UniProt (P03366) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) Pfam (PF00075) In PDB | Human immunodeficiency virus type 1 (HIV-1) | P66 RT |
2 | B | p51 RT | polymer | 437 | 51120.6 | 1 | UniProt (P03366) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) In PDB | Human immunodeficiency virus type 1 (HIV-1) | |
3 | water | water | 18.0 | 38 | Chemie (HOH) |
Sequence modifications
A: 1 - 560 (UniProt: P03366)
B: 1 - 428 (UniProt: P03366)
PDB | External Database | Details |
---|---|---|
Met -1 | - | expression tag |
Val 0 | - | expression tag |
Leu 41 | Met 640 | engineered mutation |
Asn 67 | Asp 666 | engineered mutation |
Arg 70 | Lys 669 | engineered mutation |
Tyr 215 | Thr 814 | engineered mutation |
Gln 219 | Lys 818 | engineered mutation |
Cys 258 | Gln 857 | engineered mutation |
Ser 280 | Cys 879 | engineered mutation |
Val 559 | Ile 1158 | SEE REMARK 999 |
PDB | External Database | Details |
---|---|---|
Ser 280 | Cys 879 | engineered mutation |
Gly 429 | - | expression tag |
Gly 430 | - | expression tag |
His 431 | - | expression tag |
His 432 | - | expression tag |
His 433 | - | expression tag |
His 434 | - | expression tag |
His 435 | - | expression tag |
His 436 | - | expression tag |
His 437 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 115882.9 | |
All* | Total formula weight | 115882.9 |