4BW1

The first bromodomain of human BRD4 in complex with 3,5 dimethylisoxaxole ligand

Summary for 4BW1

Entry DOI	10.2210/pdb4bw1/pdb
Related	4BW2 4BW3 4BW4
Descriptor	BROMODOMAIN-CONTAINING PROTEIN 4, 1,2-ETHANEDIOL, 4-[(2-tert-butylphenyl)amino]-7-(3,5-dimethyl-1,2-oxazol-4-yl)quinoline-3-carboxylic acid, ... (4 entities in total)
Functional Keywords	transcription, inhibitor, histone, epigenetic reader, antagonist
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Nucleus: O60885
Total number of polymer chains	1
Total formula weight	15701.07
Authors	Chung, C.,Mirguet, O.,Lamotte, Y.,Bamborough, P.,Delannee, D.,Bouillot, A.,Gellibert, F.,Krysa, G.,Lewis, A.,Witherington, J.,Huet, P.,Dudit, Y.,Trottet, L.,Nicodeme, E. (deposition date: 2013-06-29, release date: 2013-09-11, Last modification date: 2014-03-19)
Primary citation	Mirguet, O.,Lamotte, Y.,Chung, C.,Bamborough, P.,Delannee, D.,Bouillot, A.,Gellibert, F.,Krysa, G.,Lewis, A.,Witherington, J.,Huet, P.,Dudit, Y.,Trottet, L.,Nicodeme, E. Naphthyridines as Novel Bet Family Bromodomain Inhibitors. Chemmedchem, 9:589-, 2014 Cited by PubMed: 24000170 DOI: 10.1002/CMDC.201300259 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.4 Å)

Structure validation