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4BW1

The first bromodomain of human BRD4 in complex with 3,5 dimethylisoxaxole ligand

Functional Information from PDB Data
site_idAC1
Number of Residues7
DetailsBINDING SITE FOR RESIDUE EDO A 1169
ChainResidue
ASER51
AASN52
ALYS55
ALYS57
ATRP81
AS5B1172
AHOH2027

site_idAC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE EDO A 1170
ChainResidue
ALYS112
AHOH2174
AHOH2175
APRO86
AGLY108

site_idAC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE EDO A 1171
ChainResidue
AILE100
AILE101
ALYS102
ATHR103
AASN135
AHOH2114

site_idAC4
Number of Residues14
DetailsBINDING SITE FOR RESIDUE S5B A 1172
ChainResidue
ASER51
ALYS57
ATRP81
APRO82
APHE83
ALEU92
ALEU94
AASN116
AASN140
AEDO1169
AHOH2087
AHOH2091
AHOH2106
AHOH2177

Functional Information from PROSITE/UniProt
site_idPS00633
Number of Residues60
DetailsBROMODOMAIN_1 Bromodomain signature. AwpFqqpvDavklnlpDYYkiIktpMdmgtIkkrlenny..Ywnaqeciqdfnt.MftNCyiY
ChainResidueDetails
AALA80-TYR139

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues106
DetailsDomain: {"description":"Bromo 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00035","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues1
DetailsSite: {"description":"Acetylated histone binding","evidences":[{"source":"PubMed","id":"22464331","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

246704

PDB entries from 2025-12-24

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