6YCS
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![BU of 6ycs by Molmil](/molmil-images/mine/6ycs) | Human Transcription Cofactor PC4 DNA-binding domain in complex with full phosphorothioate 5-10-5 2'-O-methyl DNA gapmer antisense oligonucleotide. | Descriptor: | DNA (5'-D(P*(OKQ))-D(P*(OKT))-R(P*(RFJ))-D(*(OKQ)P*(OKT)P*(AS)P*(GS)P*(OKN)P*(OKN)P*(PST)P*(OKN)P*(PST)P*(GS)P*(GS)P*(AS)P*(OKT)P*(OKT))-3'), PC4 protein, SODIUM ION, ... | Authors: | Hyjek-Skladanowska, M, Vickers, T.A, Napiorkowska, A, Anderson, B, Tanowitz, M, Crooke, S.T, Liang, X, Seth, P.P, Nowotny, M. | Deposit date: | 2020-03-19 | Release date: | 2020-04-29 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (3.05 Å) | Cite: | Origins of the Increased Affinity of Phosphorothioate-Modified Therapeutic Nucleic Acids for Proteins. J.Am.Chem.Soc., 142, 2020
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6YNH
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![BU of 6ynh by Molmil](/molmil-images/mine/6ynh) | GAPDH purified from the supernatant of HEK293F cells: crystal form 4 of 4 | Descriptor: | 3,6,9,12,15,18,21,24,27-NONAOXANONACOSANE-1,29-DIOL, Glyceraldehyde-3-phosphate dehydrogenase | Authors: | Roversi, P, Lia, A. | Deposit date: | 2020-04-13 | Release date: | 2020-05-06 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.621 Å) | Cite: | Partial catalytic Cys oxidation of human GAPDH to Cys-sulfonic acid. Wellcome Open Res, 5, 2020
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2MQL
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![BU of 2mql by Molmil](/molmil-images/mine/2mql) | Structural Investigation of hnRNP L | Descriptor: | Protein Hnrnpl | Authors: | Blatter, M, Allain, F. | Deposit date: | 2014-06-24 | Release date: | 2015-05-06 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | The Signature of the Five-Stranded vRRM Fold Defined by Functional, Structural and Computational Analysis of the hnRNP L Protein. J.Mol.Biol., 427, 2015
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6YNE
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![BU of 6yne by Molmil](/molmil-images/mine/6yne) | GAPDH purified from the supernatant of HEK293F cells: crystal form 2 of 4. | Descriptor: | 3,6,9,12,15,18,21,24,27-NONAOXANONACOSANE-1,29-DIOL, Glyceraldehyde-3-phosphate dehydrogenase | Authors: | Roversi, P, Lia, A. | Deposit date: | 2020-04-13 | Release date: | 2020-05-06 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.853 Å) | Cite: | Partial catalytic Cys oxidation of human GAPDH to Cys-sulfonic acid. Wellcome Open Res, 5, 2020
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2MQO
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![BU of 2mqo by Molmil](/molmil-images/mine/2mqo) | |
2MVW
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![BU of 2mvw by Molmil](/molmil-images/mine/2mvw) | Solution structure of the TRIM19 B-box1 (B1) of human promyelocytic leukemia (PML) | Descriptor: | Protein PML, ZINC ION | Authors: | Huang, S, Naik, M.T, Fan, P, Wang, Y, Chang, C, Huang, T. | Deposit date: | 2014-10-17 | Release date: | 2014-11-12 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | The B-box 1 dimer of human promyelocytic leukemia protein. J.Biomol.Nmr, 60, 2014
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4J0R
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![BU of 4j0r by Molmil](/molmil-images/mine/4j0r) | Crystal Structure of the first bromodomain of human BRD4 in complex with a 3,5-dimethylisoxazol ligand | Descriptor: | 1,2-ETHANEDIOL, 3-(3,5-dimethyl-1,2-oxazol-4-yl)-5-[(R)-hydroxy(phenyl)methyl]phenol, Bromodomain-containing protein 4, ... | Authors: | Filippakopoulos, P, Picaud, S, Qi, J, Felletar, I, Hewings, D.S, von Delft, F, Conway, S.J, Bountra, C, Arrowsmith, C.H, Edwards, A, Knapp, S, Structural Genomics Consortium (SGC) | Deposit date: | 2013-01-31 | Release date: | 2013-02-13 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.72 Å) | Cite: | Optimization of 3,5-dimethylisoxazole derivatives as potent bromodomain ligands. J.Med.Chem., 56, 2013
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2MZN
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![BU of 2mzn by Molmil](/molmil-images/mine/2mzn) | |
2N1U
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![BU of 2n1u by Molmil](/molmil-images/mine/2n1u) | Structure of SAP30L corepressor protein | Descriptor: | Histone deacetylase complex subunit SAP30L, ZINC ION | Authors: | Tossavainen, H, Permi, P. | Deposit date: | 2015-04-23 | Release date: | 2015-11-25 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Redox-dependent disulfide bond formation in SAP30L corepressor protein: Implications for structure and function. Protein Sci., 25, 2016
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6Y08
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![BU of 6y08 by Molmil](/molmil-images/mine/6y08) | Mouse thymidylate synthase cocrystallized with dUMP and soaked in sulfamethoxazole | Descriptor: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, Sulfamethoxazole, Thymidylate synthase | Authors: | Maj, P, Jarmula, A, Wilk, P, Weiss, M.S, Rode, W. | Deposit date: | 2020-02-06 | Release date: | 2021-02-17 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.297 Å) | Cite: | Mouse thymidylate synthase cocrystallized with dUMP and soaked in sulfamethoxazole To Be Published
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2MXC
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![BU of 2mxc by Molmil](/molmil-images/mine/2mxc) | Solution structure of the full length sorting nexin 3 | Descriptor: | Sorting nexin-3 | Authors: | Lenoir, M.M.L, Rajesh, S.S.R, Gruenberg, J.J.G, Overduin, M.M.O, Kaur, J.J.K. | Deposit date: | 2014-12-20 | Release date: | 2016-05-04 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Phosphorylation of conserved phosphoinositide binding pocket regulates sorting nexin membrane targeting. Nat Commun, 9, 2018
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2MQN
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![BU of 2mqn by Molmil](/molmil-images/mine/2mqn) | Structural Investigation of hnRNP L | Descriptor: | Heterogenous nuclear ribonucleoprotein L | Authors: | Blatter, M, Allain, F. | Deposit date: | 2014-06-24 | Release date: | 2015-05-06 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | The Signature of the Five-Stranded vRRM Fold Defined by Functional, Structural and Computational Analysis of the hnRNP L Protein. J.Mol.Biol., 427, 2015
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6YQZ
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![BU of 6yqz by Molmil](/molmil-images/mine/6yqz) | N-terminal domain of BRD4 with biphenyl-methyamino-dimethylpyridazinone | Descriptor: | 1,2-ETHANEDIOL, 2,4-dimethyl-5-[(2-phenylphenyl)methylamino]pyridazin-3-one, Bromodomain-containing protein 4 | Authors: | Chung, C. | Deposit date: | 2020-04-18 | Release date: | 2021-03-24 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.39 Å) | Cite: | Application of Atypical Acetyl-lysine Methyl Mimetics in the Development of Selective Inhibitors of the Bromodomain-Containing Protein 7 (BRD7)/Bromodomain-Containing Protein 9 (BRD9) Bromodomains. J.Med.Chem., 63, 2020
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4J0S
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![BU of 4j0s by Molmil](/molmil-images/mine/4j0s) | Crystal Structure of the first bromodomain of human BRD4 in complex with a 3,5-dimethylisoxazol ligand | Descriptor: | 1,2-ETHANEDIOL, 3-(3,5-dimethyl-1,2-oxazol-4-yl)-5-[(S)-hydroxy(phenyl)methyl]phenol, Bromodomain-containing protein 4 | Authors: | Filippakopoulos, P, Picaud, S, Qi, J, Felletar, I, Hewings, D.S, von Delft, F, Conway, S.J, Bountra, C, Arrowsmith, C.H, Edwards, A, Knapp, S, Structural Genomics Consortium (SGC) | Deposit date: | 2013-01-31 | Release date: | 2013-02-13 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.84 Å) | Cite: | Optimization of 3,5-dimethylisoxazole derivatives as potent bromodomain ligands. J.Med.Chem., 56, 2013
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2MWX
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![BU of 2mwx by Molmil](/molmil-images/mine/2mwx) | The RING Domain of human Promyelocytic Leukemia Protein (PML) | Descriptor: | Protein PML, ZINC ION | Authors: | Huang, S.Y, Chang, C.F, Fan, P.J, Guntert, P, Shih, H.M, Huang, T.H. | Deposit date: | 2014-12-02 | Release date: | 2015-02-11 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | The RING domain of human promyelocytic leukemia protein (PML). J.Biomol.Nmr, 61, 2015
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4J19
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![BU of 4j19 by Molmil](/molmil-images/mine/4j19) | Structure of a novel telomere repeat binding protein bound to DNA | Descriptor: | CHLORIDE ION, DNA (5'-D(*CP*TP*GP*TP*TP*AP*GP*GP*GP*TP*TP*AP*GP*GP*GP*TP*TP*AP*G)-3'), DNA (5'-D(*TP*CP*TP*AP*AP*CP*CP*CP*TP*AP*AP*CP*CP*CP*TP*AP*AP*CP*A)-3'), ... | Authors: | Kappei, D, Butter, F, Benda, C, Scheibe, M, Draskovic, I, Stevense, M, Lopes Novo, C, Basquin, C, Krastev, D.B, Kittler, R, Jessberger, R, Londono-Vallejo, A.J, Mann, M, Buchholz, F. | Deposit date: | 2013-02-01 | Release date: | 2013-05-29 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | HOT1 is a mammalian direct telomere repeat-binding protein contributing to telomerase recruitment. Embo J., 32, 2013
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2MQQ
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2BQ0
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![BU of 2bq0 by Molmil](/molmil-images/mine/2bq0) | 14-3-3 Protein Beta (Human) | Descriptor: | 14-3-3 BETA/ALPHA | Authors: | Yang, X, Elkins, J.M, Fedorov, O, Longman, E.J, Sobott, L, Ball, L.J, Sundstrom, M, Arrowsmith, C, Edwards, A, Doyle, D.A. | Deposit date: | 2005-04-26 | Release date: | 2005-05-06 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural Basis for Protein-Protein Interactions in the 14-3-3 Protein Family. Proc.Natl.Acad.Sci.USA, 103, 2006
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2BR9
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![BU of 2br9 by Molmil](/molmil-images/mine/2br9) | 14-3-3 Protein Epsilon (Human) Complexed to Peptide | Descriptor: | 14-3-3 PROTEIN EPSILON, CONSENSUS PEPTIDE FOR 14-3-3 PROTEINS | Authors: | Yang, X, Elkins, J.M, Soundararajan, M, Fedorov, O, Sundstrom, M, Edwards, A, Arrowsmith, C, Doyle, D.A. | Deposit date: | 2005-05-03 | Release date: | 2005-05-12 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Structural Basis for Protein-Protein Interactions in the 14-3-3 Protein Family. Proc.Natl.Acad.Sci.USA, 103, 2006
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2BKU
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![BU of 2bku by Molmil](/molmil-images/mine/2bku) | Kap95p:RanGTP complex | Descriptor: | GTP-BINDING NUCLEAR PROTEIN RAN, GUANOSINE-5'-TRIPHOSPHATE, IMPORTIN BETA-1 SUBUNIT, ... | Authors: | Lee, S.J, Matsuura, Y, Liu, S.M, Stewart, M. | Deposit date: | 2005-02-21 | Release date: | 2005-05-04 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural Basis for Nuclear Import Complex Dissociation by Rangtp Nature, 435, 2005
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2C23
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![BU of 2c23 by Molmil](/molmil-images/mine/2c23) | 14-3-3 Protein Beta (Human) in complex with exoenzyme S peptide | Descriptor: | 14-3-3 BETA/ALPHA, EXOENZYME S PEPTIDE | Authors: | Elkins, J.M, Schoch, G.A, Yang, X, Sundstrom, M, Arrowsmith, C, Edwards, A, Doyle, D.A. | Deposit date: | 2005-09-26 | Release date: | 2005-09-29 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Structural Basis for Protein-Protein Interactions in the 14-3-3 Protein Family. Proc.Natl.Acad.Sci.USA, 103, 2006
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2N5N
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![BU of 2n5n by Molmil](/molmil-images/mine/2n5n) | Structure of an N-terminal domain of CHD4 | Descriptor: | Chromodomain-helicase-DNA-binding protein 4 | Authors: | Silva, A.P.G, Mackay, J.P. | Deposit date: | 2015-07-22 | Release date: | 2015-11-18 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | The N-terminal Region of Chromodomain Helicase DNA-binding Protein 4 (CHD4) Is Essential for Activity and Contains a High Mobility Group (HMG) Box-like-domain That Can Bind Poly(ADP-ribose). J.Biol.Chem., 291, 2016
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2MZU
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![BU of 2mzu by Molmil](/molmil-images/mine/2mzu) | |
4IPZ
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![BU of 4ipz by Molmil](/molmil-images/mine/4ipz) | SmBz bound to Cyclophilin A | Descriptor: | CHLORIDE ION, Peptidyl-prolyl cis-trans isomerase A, cyclosporine SmBz-CsA | Authors: | Price, A.J, Jacques, D.A, James, L.C. | Deposit date: | 2013-01-10 | Release date: | 2013-11-06 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.67 Å) | Cite: | HIV-1 evades innate immune recognition through specific cofactor recruitment. Nature, 503, 2013
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2MUU
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![BU of 2muu by Molmil](/molmil-images/mine/2muu) | |