4J0R
Crystal Structure of the first bromodomain of human BRD4 in complex with a 3,5-dimethylisoxazol ligand
Summary for 4J0R
Entry DOI | 10.2210/pdb4j0r/pdb |
Related | 4J0S |
Descriptor | Bromodomain-containing protein 4, 1,2-ETHANEDIOL, 3-(3,5-dimethyl-1,2-oxazol-4-yl)-5-[(R)-hydroxy(phenyl)methyl]phenol, ... (5 entities in total) |
Functional Keywords | brd4, bromodomain containing protein 4, cap, hunk1, mcap, mitotic chromosome associated protein, isoxazole, structural genomics consortium, sgc, signaling protein |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus (By similarity): O60885 |
Total number of polymer chains | 1 |
Total formula weight | 15769.89 |
Authors | Filippakopoulos, P.,Picaud, S.,Qi, J.,Felletar, I.,Hewings, D.S.,von Delft, F.,Conway, S.J.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2013-01-31, release date: 2013-02-13, Last modification date: 2023-09-20) |
Primary citation | Hewings, D.S.,Fedorov, O.,Filippakopoulos, P.,Martin, S.,Picaud, S.,Tumber, A.,Wells, C.,Olcina, M.M.,Freeman, K.,Gill, A.,Ritchie, A.J.,Sheppard, D.W.,Russell, A.J.,Hammond, E.M.,Knapp, S.,Brennan, P.E.,Conway, S.J. Optimization of 3,5-dimethylisoxazole derivatives as potent bromodomain ligands. J.Med.Chem., 56:3217-3227, 2013 Cited by PubMed: 23517011DOI: 10.1021/jm301588r PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.72 Å) |
Structure validation
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