6YQZ

N-terminal domain of BRD4 with biphenyl-methyamino-dimethylpyridazinone

Summary for 6YQZ

Entry DOI	10.2210/pdb6yqz/pdb
Descriptor	Bromodomain-containing protein 4, 2,4-dimethyl-5-[(2-phenylphenyl)methylamino]pyridazin-3-one, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywords	brd4, inhibitor, histone, epigenetic reader, bromodomain, transcription
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	15466.82
Authors	Chung, C. (deposition date: 2020-04-18, release date: 2021-03-24)
Primary citation	Clegg, M.A.,Bamborough, P.,Chung, C.W.,Craggs, P.D.,Gordon, L.,Grandi, P.,Leveridge, M.,Lindon, M.,Liwicki, G.M.,Michon, A.M.,Molnar, J.,Rioja, I.,Soden, P.E.,Theodoulou, N.H.,Werner, T.,Tomkinson, N.C.O.,Prinjha, R.K.,Humphreys, P.G. Application of Atypical Acetyl-lysine Methyl Mimetics in the Development of Selective Inhibitors of the Bromodomain-Containing Protein 7 (BRD7)/Bromodomain-Containing Protein 9 (BRD9) Bromodomains. J.Med.Chem., 63:5816-5840, 2020 Cited by PubMed: 32410449 DOI: 10.1021/acs.jmedchem.0c00075 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.39 Å)

Structure validation