6YCS

Human Transcription Cofactor PC4 DNA-binding domain in complex with full phosphorothioate 5-10-5 2'-O-methyl DNA gapmer antisense oligonucleotide.

Summary for 6YCS

Entry DOI	10.2210/pdb6ycs/pdb
Descriptor	PC4 protein, DNA (5'-D(P(OKQ))-D(P(OKT))-R(P(RFJ))-D((OKQ)P(OKT)P(AS)P(GS)P(OKN)P(OKN)P(PST)P(OKN)P(PST)P(GS)P(GS)P(AS)P(OKT)P*(OKT))-3'), SULFATE ION, ... (6 entities in total)
Functional Keywords	dna binding, phosphorothioate dna, 2'-o-methyl, aso, transcription
Biological source	Homo sapiens (Human) More
Total number of polymer chains	6
Total formula weight	45750.96
Authors	Hyjek-Skladanowska, M.,Vickers, T.A.,Napiorkowska, A.,Anderson, B.,Tanowitz, M.,Crooke, S.T.,Liang, X.,Seth, P.P.,Nowotny, M. (deposition date: 2020-03-19, release date: 2020-04-29, Last modification date: 2024-01-24)
Primary citation	Hyjek-Skladanowska, M.,Vickers, T.A.,Napiorkowska, A.,Anderson, B.A.,Tanowitz, M.,Crooke, S.T.,Liang, X.H.,Seth, P.P.,Nowotny, M. Origins of the Increased Affinity of Phosphorothioate-Modified Therapeutic Nucleic Acids for Proteins. J.Am.Chem.Soc., 142:7456-7468, 2020 Cited by PubMed: 32202774 DOI: 10.1021/jacs.9b13524 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.05 Å)

Structure validation