6YCS
Human Transcription Cofactor PC4 DNA-binding domain in complex with full phosphorothioate 5-10-5 2'-O-methyl DNA gapmer antisense oligonucleotide.
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003677 | molecular_function | DNA binding |
A | 0003713 | molecular_function | transcription coactivator activity |
A | 0006355 | biological_process | regulation of DNA-templated transcription |
A | 0060261 | biological_process | positive regulation of transcription initiation by RNA polymerase II |
B | 0003677 | molecular_function | DNA binding |
B | 0003713 | molecular_function | transcription coactivator activity |
B | 0006355 | biological_process | regulation of DNA-templated transcription |
B | 0060261 | biological_process | positive regulation of transcription initiation by RNA polymerase II |
C | 0003677 | molecular_function | DNA binding |
C | 0003713 | molecular_function | transcription coactivator activity |
C | 0006355 | biological_process | regulation of DNA-templated transcription |
C | 0060261 | biological_process | positive regulation of transcription initiation by RNA polymerase II |
D | 0003677 | molecular_function | DNA binding |
D | 0003713 | molecular_function | transcription coactivator activity |
D | 0006355 | biological_process | regulation of DNA-templated transcription |
D | 0060261 | biological_process | positive regulation of transcription initiation by RNA polymerase II |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 2 |
Details | binding site for residue SO4 A 201 |
Chain | Residue |
A | ARG100 |
E | HOH201 |
site_id | AC2 |
Number of Residues | 3 |
Details | binding site for residue NA E 101 |
Chain | Residue |
A | ARG100 |
E | GS13 |
E | GS14 |
site_id | AC3 |
Number of Residues | 11 |
Details | binding site for residues OKT E 2 and RFJ E 3 |
Chain | Residue |
B | ARG100 |
C | ARG100 |
D | ARG100 |
E | OKQ4 |
F | OKN8 |
F | PST10 |
F | PST12 |
B | ARG86 |
B | TRP89 |
B | PRO98 |
B | GLY99 |
site_id | AC4 |
Number of Residues | 14 |
Details | binding site for residues RFJ E 3 and OKQ E 4 |
Chain | Residue |
A | ARG100 |
A | LYS101 |
B | LEU82 |
B | ARG86 |
B | PRO98 |
B | GLY99 |
B | ARG100 |
C | ARG100 |
D | ARG100 |
E | OKT2 |
E | OKT5 |
F | GS7 |
F | OKN8 |
F | PST10 |
site_id | AC5 |
Number of Residues | 11 |
Details | binding site for residues OKQ E 4 and OKT E 5 |
Chain | Residue |
A | ARG70 |
A | ARG100 |
A | LYS101 |
B | PHE77 |
B | LEU82 |
B | ARG86 |
E | RFJ3 |
E | PPS6 |
F | PPS6 |
F | GS7 |
F | OKN8 |
site_id | AC6 |
Number of Residues | 12 |
Details | binding site for residues GS E 7 and OKN E 8 |
Chain | Residue |
A | ILE66 |
A | GLY67 |
A | LYS68 |
B | ASN106 |
B | GLU108 |
B | GLN109 |
E | PPS6 |
E | OKN9 |
E | HOH201 |
F | RFJ3 |
F | OKQ4 |
F | OKT5 |
site_id | AC7 |
Number of Residues | 15 |
Details | binding site for residues OKN E 8 and OKN E 9 |
Chain | Residue |
A | GLN65 |
A | ILE66 |
A | GLY67 |
A | LYS68 |
B | ASN106 |
B | GLU108 |
B | GLN109 |
B | GLN112 |
C | PHE77 |
E | GS7 |
E | PST10 |
E | OKN11 |
E | HOH202 |
F | OKT2 |
F | RFJ3 |
site_id | AC8 |
Number of Residues | 12 |
Details | binding site for residues OKN E 9 and PST E 10 |
Chain | Residue |
A | GLN65 |
A | ILE66 |
A | GLY67 |
B | GLN112 |
C | ARG75 |
C | PHE77 |
C | LYS78 |
E | OKN8 |
E | OKN11 |
E | HOH202 |
F | OKT2 |
F | RFJ3 |
site_id | AC9 |
Number of Residues | 6 |
Details | binding site for residues PST E 10 and OKN E 11 |
Chain | Residue |
C | ARG75 |
C | PHE77 |
C | LYS78 |
E | OKN9 |
E | PST12 |
F | OKT2 |
site_id | AD1 |
Number of Residues | 8 |
Details | binding site for residues OKN E 11 and PST E 12 |
Chain | Residue |
A | TRP89 |
A | MET90 |
A | PRO92 |
C | LYS97 |
E | OKN9 |
E | PST10 |
E | GS13 |
F | OKT2 |
site_id | AD2 |
Number of Residues | 14 |
Details | binding site for residues PST E 12 and GS E 13 |
Chain | Residue |
C | ASP91 |
C | PRO92 |
C | GLU95 |
C | LYS97 |
E | OKN11 |
E | GS14 |
E | NA101 |
F | OKQ1 |
F | OKT2 |
A | TRP89 |
A | MET90 |
A | PRO92 |
A | PRO98 |
A | ARG100 |
site_id | AD3 |
Number of Residues | 15 |
Details | binding site for residues GS E 13 and GS E 14 |
Chain | Residue |
A | SER73 |
A | ARG75 |
A | ARG86 |
A | TYR88 |
A | TRP89 |
A | PRO98 |
A | GLY99 |
A | ARG100 |
C | ASP91 |
C | PRO92 |
C | GLU95 |
E | PST12 |
E | PPS15 |
E | NA101 |
F | OKQ1 |
site_id | AD4 |
Number of Residues | 6 |
Details | binding site for residues OKT E 16 and OKT E 17 |
Chain | Residue |
A | LYS80 |
A | LEU82 |
A | ASN106 |
B | ARG70 |
B | LYS101 |
E | PPS15 |
site_id | AD5 |
Number of Residues | 11 |
Details | binding site for residues OKQ F 1 and OKT F 2 |
Chain | Residue |
A | ARG100 |
C | ARG86 |
C | TRP89 |
C | PRO98 |
C | GLY99 |
C | ARG100 |
E | OKN9 |
E | OKN11 |
E | PST12 |
E | GS13 |
F | RFJ3 |
site_id | AD6 |
Number of Residues | 11 |
Details | binding site for residues OKQ F 1 and OKT F 2 |
Chain | Residue |
A | ARG100 |
C | ARG86 |
C | TRP89 |
C | PRO98 |
C | GLY99 |
C | ARG100 |
E | OKN9 |
E | OKN11 |
E | PST12 |
E | GS13 |
F | RFJ3 |
site_id | AD7 |
Number of Residues | 15 |
Details | binding site for residues OKT F 2 and RFJ F 3 |
Chain | Residue |
C | ARG75 |
C | PHE77 |
C | LEU82 |
C | ARG86 |
C | GLY99 |
C | ARG100 |
C | SER104 |
C | HOH201 |
E | GS7 |
E | OKN8 |
E | OKN9 |
E | OKN11 |
E | PST12 |
F | OKQ1 |
F | OKQ4 |
site_id | AD8 |
Number of Residues | 13 |
Details | binding site for residues RFJ F 3 and OKQ F 4 |
Chain | Residue |
C | ARG75 |
C | PHE77 |
C | LEU82 |
C | ARG86 |
C | SER104 |
C | HOH201 |
D | ARG70 |
D | LYS101 |
E | GS7 |
E | OKN8 |
E | OKN9 |
F | OKT2 |
F | OKT5 |
site_id | AD9 |
Number of Residues | 8 |
Details | binding site for residues OKQ F 4 and OKT F 5 |
Chain | Residue |
C | PHE77 |
C | SER104 |
D | ARG70 |
D | LYS101 |
E | PPS6 |
E | GS7 |
F | RFJ3 |
F | PPS6 |
site_id | AE1 |
Number of Residues | 5 |
Details | binding site for residues GS F 7 and OKN F 8 |
Chain | Residue |
E | RFJ3 |
E | OKQ4 |
E | OKT5 |
F | PPS6 |
F | PST10 |
site_id | AE2 |
Number of Residues | 12 |
Details | binding site for residues PST F 10 and OKN F 11 |
Chain | Residue |
B | GLU93 |
B | LYS97 |
D | ARG75 |
D | ASP84 |
D | ARG86 |
D | TRP89 |
D | PRO98 |
D | GLY99 |
D | ARG100 |
E | RFJ3 |
F | OKN8 |
F | PST12 |
site_id | AE3 |
Number of Residues | 14 |
Details | binding site for residues OKN F 11 and PST F 12 |
Chain | Residue |
B | GLU93 |
B | LYS97 |
C | ARG100 |
D | ARG75 |
D | PHE77 |
D | ASP84 |
D | ARG86 |
D | PRO98 |
D | GLY99 |
D | ARG100 |
D | SER104 |
E | OKT2 |
F | PST10 |
F | GS13 |
site_id | AE4 |
Number of Residues | 10 |
Details | binding site for residues PST F 12 and GS F 13 |
Chain | Residue |
B | GLU93 |
C | ARG70 |
C | ARG100 |
C | LYS101 |
D | ARG75 |
D | PHE77 |
D | ARG86 |
D | SER104 |
E | OKT2 |
F | OKN11 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | MOD_RES: N6-acetyllysine; alternate => ECO:0007744|PubMed:19608861 |
Chain | Residue | Details |
A | LYS68 | |
B | LYS68 | |
C | LYS68 | |
D | LYS68 |
site_id | SWS_FT_FI2 |
Number of Residues | 4 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
Chain | Residue | Details |
A | SER118 | |
B | SER118 | |
C | SER118 | |
D | SER118 |
site_id | SWS_FT_FI3 |
Number of Residues | 8 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:28112733 |
Chain | Residue | Details |
A | LYS68 | |
B | LYS68 | |
C | LYS68 | |
D | LYS68 |