6YCS
Human Transcription Cofactor PC4 DNA-binding domain in complex with full phosphorothioate 5-10-5 2'-O-methyl DNA gapmer antisense oligonucleotide.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | PC4 protein | polymer | 72 | 8468.7 | 4 | UniProt (Q6IBA2) Pfam (PF02229) UniProt (by SIFTS) (P53999) | Homo sapiens (Human) | SUB1 homolog (S. cerevisiae),isoform CRA_a,cDNA,FLJ92014,highly similar to Homo sapiens SUB1 homolog (S. cerevisiae) (SUB1),mRNA |
| 2 | E (E) | DNA (5'-D(P*(OKQ))-D(P*(OKT))-R(P*(RFJ))-D(*(OKQ)P*(OKT)P*(AS)P*(GS)P*(OKN)P*(OKN)P*(PST)P*(OKN)P*(PST)P*(GS)P*(GS)P*(AS)P*(OKT)P*(OKT))-3') | polymer | 17 | 5958.6 | 1 | synthetic construct | ||
| 3 | F (F) | DNA (5'-D(P*(OKQ))-D(P*(OKT))-R(P*(RFJ))-D(*(OKQ)P*(OKT)P*(AS)P*(GS)P*(OKN)P*(OKN)P*(PST)P*(OKN)P*(PST)P*(GS)P*(GS)P*(AS)P*(OKT)P*(OKT))-3') | polymer | 17 | 5798.6 | 1 | synthetic construct | ||
| 4 | G (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 5 | H (E) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 6 | I, J, K, L, M (A, B, C, D, E) | water | water | 18.0 | 12 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 61 - 127 (UniProt: Q6IBA2)
| PDB | External Database | Details |
|---|---|---|
| Arg 56 | - | expression tag |
| Gly 57 | - | expression tag |
| Ser 58 | - | expression tag |
| His 59 | - | expression tag |
| Ser 60 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 45631.9 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 119.1 | |
| All* | Total formula weight | 45751.0 |
