PDB: 8880 resultsInfo pagesStatus searchChemie searchBIRD

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6CBD	Crystal Structure of Human Argonaute2 Bound to Three Tryptophans Descriptor: Guide RNA, ISOPROPYL ALCOHOL, MAGNESIUM ION, ... Authors: Sheu-Gruttadauria, J, MacRae, I.J. Deposit date: 2018-02-02 Release date: 2018-04-18 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.203 Å) Cite: Phase Transitions in the Assembly and Function of Human miRISC. Cell, 173, 2018
6JOU	Crystal structure of the human nucleosome containing H2A.Z.1 S42R Descriptor: DNA (146-MER), Histone H2A.Z, Histone H2B type 1-J, ... Authors: Horikoshi, N, Sato, K, Mizukami, Y, Kurumizaka, H. Deposit date: 2019-03-23 Release date: 2020-03-25 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.17 Å) Cite: Structure-based design of an H2A.Z.1 mutant stabilizing a nucleosome in vitro and in vivo. Biochem.Biophys.Res.Commun., 515, 2019
7PMN	S. cerevisiae replisome-SCF(Dia2) complex bound to double-stranded DNA (conformation II) Descriptor: Cell division control protein 45,Cell division control protein 45, Chromosome segregation in meiosis protein 3, DNA polymerase alpha-binding protein, ... Authors: Jenkyn-Bedford, M, Yeeles, J.T.P, Deegan, T.D. Deposit date: 2021-09-02 Release date: 2021-11-10 Last modified: 2024-07-17 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: A conserved mechanism for regulating replisome disassembly in eukaryotes. Nature, 600, 2021
6AQR	SAGA DUB module Ubp8(C146A)/Sgf11/Sus1/Sgf73 bound to monoubiquitin Descriptor: Polyubiquitin-C, SAGA-associated factor 11, SAGA-associated factor 73, ... Authors: Morrow, M.E, Morgan, M.T, Wolberger, C. Deposit date: 2017-08-21 Release date: 2018-07-04 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Active site alanine mutations convert deubiquitinases into high-affinity ubiquitin-binding proteins. EMBO Rep., 19, 2018
5OF3	Crystal structure of the heterotrimeric PriSLX primase from S. solfataricus. Descriptor: DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, DNA primase large subunit PriL, DNA primase small subunit PriS, ... Authors: Pellegrini, L, Holzer, S. Deposit date: 2017-07-10 Release date: 2017-11-29 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.906 Å) Cite: Primer synthesis by a eukaryotic-like archaeal primase is independent of its Fe-S cluster. Nat Commun, 8, 2017
1H6K	nuclear Cap Binding Complex Descriptor: 20 KDA NUCLEAR CAP BINDING PROTEIN, CBP80 Authors: Mazza, C, Ohno, M, Segref, A, Mattaj, I.W, Cusack, S. Deposit date: 2001-06-18 Release date: 2001-09-13 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystal Structure of the Human Nuclear CAP Binding Complex Mol.Cell, 8, 2001
3EVE	Crystal structure of GpppA complex of yellow fever virus methyltransferase and S-adenosyl-L-homocysteine Descriptor: GUANOSINE-P3-ADENOSINE-5',5'-TRIPHOSPHATE, RNA-directed RNA polymerase NS5, S-ADENOSYL-L-HOMOCYSTEINE Authors: Thompson, A.A. Deposit date: 2008-10-13 Release date: 2009-01-06 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Analysis of flavivirus NS5 methyltransferase cap binding. J.Mol.Biol., 385, 2009
3EVF	Crystal structure of Me7-GpppA complex of yellow fever virus methyltransferase and S-adenosyl-L-homocysteine Descriptor: P1-7-METHYLGUANOSINE-P3-ADENOSINE-5',5'-TRIPHOSPHATE, RNA-directed RNA polymerase NS5, S-ADENOSYL-L-HOMOCYSTEINE Authors: Thompson, A.A, Geiss, B.J, Peersen, O.B. Deposit date: 2008-10-13 Release date: 2009-01-06 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.45 Å) Cite: Analysis of flavivirus NS5 methyltransferase cap binding. J.Mol.Biol., 385, 2009
4TN2	NS5b in complex with lactam-thiophene carboxylic acids Descriptor: 3-[(2R)-2-cyclohexyl-5-oxopyrrolidin-1-yl]-5-phenylthiophene-2-carboxylic acid, Genome polyprotein Authors: Chopra, R. Deposit date: 2014-06-02 Release date: 2014-09-17 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Design and synthesis of lactam-thiophene carboxylic acids as potent hepatitis C virus polymerase inhibitors. Bioorg.Med.Chem.Lett., 24, 2014
1ID3	CRYSTAL STRUCTURE OF THE YEAST NUCLEOSOME CORE PARTICLE REVEALS FUNDAMENTAL DIFFERENCES IN INTER-NUCLEOSOME INTERACTIONS Descriptor: HISTONE H2A.1, HISTONE H2B.2, HISTONE H3, ... Authors: White, C.L, Suto, R.K, Luger, K. Deposit date: 2001-04-03 Release date: 2001-09-28 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (3.1 Å) Cite: Structure of the yeast nucleosome core particle reveals fundamental changes in internucleosome interactions. EMBO J., 20, 2001
7CYQ	Cryo-EM structure of an extended SARS-CoV-2 replication and transcription complex reveals an intermediate state in cap synthesis Descriptor: GUANOSINE-5'-DIPHOSPHATE, Helicase, MAGNESIUM ION, ... Authors: Yan, L, Ge, J, Zheng, L, Zhang, Y, Gao, Y, Wang, T, Wang, H, Huang, Y, Li, M, Wang, Q, Rao, Z, Lou, Z. Deposit date: 2020-09-04 Release date: 2020-12-09 Last modified: 2024-03-27 Method: ELECTRON MICROSCOPY (2.83 Å) Cite: Cryo-EM Structure of an Extended SARS-CoV-2 Replication and Transcription Complex Reveals an Intermediate State in Cap Synthesis. Cell, 184, 2021
3EVC	Crystal structure of GTP complex of yellow fever virus methyltransferase and S-adenosyl-L-homocysteine Descriptor: GUANOSINE-5'-TRIPHOSPHATE, RNA-directed RNA polymerase NS5, S-ADENOSYL-L-HOMOCYSTEINE Authors: Thompson, A.A, Geiss, B.J, Peersen, O.B. Deposit date: 2008-10-13 Release date: 2009-01-06 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Analysis of flavivirus NS5 methyltransferase cap binding. J.Mol.Biol., 385, 2009
8VLB	Crystal structure of EloBC-VHL-CDO1 complex bound to compound 4 molecular glue Descriptor: CITRIC ACID, Cysteine dioxygenase type 1, Elongin-B, ... Authors: Shu, W, Ma, X, Tutter, A, Buckley, D, Golosov, A, Michaud, G. Deposit date: 2024-01-11 Release date: 2024-03-13 Method: X-RAY DIFFRACTION (2.9 Å) Cite: A small molecule VHL molecular glue degrader for cysteine dioxygenase 1 To Be Published
8VL9	Crystal structure of EloBC-VHL-CDO1 complex bound to compound 8 molecular glue Descriptor: CITRIC ACID, Cysteine dioxygenase type 1, Elongin-B, ... Authors: Shu, W, Ma, X, Tutter, A, Buckley, D, Golosov, A, Michaud, G. Deposit date: 2024-01-11 Release date: 2024-03-13 Method: X-RAY DIFFRACTION (2.5 Å) Cite: A small molecule VHL molecular glue degrader for cysteine dioxygenase 1 To Be Published
7V1F	Crystal structure of Omsk hemorrhagic fever virus NS5 MTase (in complex with SAM and GTP) Descriptor: Core protein, GLYCEROL, GUANOSINE-5'-TRIPHOSPHATE, ... Authors: Jia, H, Gong, P. Deposit date: 2021-08-04 Release date: 2022-06-15 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystal Structures of Flavivirus NS5 Guanylyltransferase Reveal a GMP-Arginine Adduct. J.Virol., 96, 2022
1B72	PBX1, HOMEOBOX PROTEIN HOX-B1/DNA TERNARY COMPLEX Descriptor: DNA (5'-D(*AP*CP*TP*CP*TP*AP*TP*GP*AP*TP*TP*GP*AP*TP*CP*GP*GP*CP*TP*G)-3'), DNA (5'-D(*TP*CP*AP*GP*CP*CP*GP*AP*TP*CP*AP*AP*TP*CP*AP*TP*AP*GP*AP*G)-3'), PROTEIN (HOMEOBOX PROTEIN HOX-B1), ... Authors: Piper, D.E, Batchelor, A.H, Chang, C.-P, Cleary, M.L, Wolberger, C. Deposit date: 1999-01-27 Release date: 1999-02-19 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2.35 Å) Cite: Structure of a HoxB1-Pbx1 heterodimer bound to DNA: role of the hexapeptide and a fourth homeodomain helix in complex formation. Cell(Cambridge,Mass.), 96, 1999
5X7X	The crystal structure of the nucleosome containing H3.3 at 2.18 angstrom resolution Descriptor: CHLORIDE ION, DNA (146-MER), Histone H2A type 1-B/E, ... Authors: Arimura, Y, Taguchi, H, Kurumizaka, H. Deposit date: 2017-02-27 Release date: 2017-04-19 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.184 Å) Cite: Crystal Structure and Characterization of Novel Human Histone H3 Variants, H3.6, H3.7, and H3.8 Biochemistry, 56, 2017
5G5P	Structure of the Saccharomyces cerevisiae TREX-2 complex Descriptor: 26S PROTEASOME COMPLEX SUBUNIT SEM1, NUCLEAR MRNA EXPORT PROTEIN SAC3, NUCLEAR MRNA EXPORT PROTEIN THP1 Authors: Aibara, S, Bai, X.C, Stewart, M. Deposit date: 2016-05-26 Release date: 2016-11-23 Last modified: 2024-05-08 Method: ELECTRON MICROSCOPY (5.3 Å) Cite: The Sac3 Tpr-Like Region in the Saccharomyces Cerevisiae Trex-2 Complex is More Extensive But Independent of the Cid Region J.Struct.Biol., 195, 2016
3EVD	Crystal structure of GTP complex of yellow fever virus methyltransferase and S-adenosyl-L-homocysteine Descriptor: GUANOSINE-5'-TRIPHOSPHATE, RNA-directed RNA polymerase NS5, S-ADENOSYL-L-HOMOCYSTEINE Authors: Thompson, A.A, Geiss, B.J, Peersen, O.B. Deposit date: 2008-10-13 Release date: 2009-01-06 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Analysis of flavivirus NS5 methyltransferase cap binding. J.Mol.Biol., 385, 2009
2W9B	Binary complex of Dpo4 bound to N2,N2-dimethyl-deoxyguanosine modified DNA Descriptor: 5'-D(*GP*GP*GP*GP*GP*AP*AP*GP*GP*AP *TP*TP*CP*DOCP)-3', 5'-D(*TP*CP*AP*TP*M2GP*GP*AP*AP*TP*CP*CP *TP*TP*CP*CP*CP*CP*C)-3', DNA POLYMERASE IV, ... Authors: Eoff, R.L, Zhang, H, Kosekov, I.D, Rizzo, C.J, Egli, M, Guengerich, F.P. Deposit date: 2009-01-22 Release date: 2009-05-12 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.28 Å) Cite: Structure-Function Relationships in Miscoding by Sulfolobus Solfataricus DNA Polymerase Dpo4: Guanine N2,N2-Dimethyl Substitution Produces Inactive and Miscoding Polymerase Complexes. J.Biol.Chem., 284, 2009
5R8Y	PanDDA analysis group deposition Form1 MAP kinase p38-alpha -- Fragment N08078b in complex with MAP kinase p38-alpha Descriptor: CHLORIDE ION, DIMETHYL SULFOXIDE, MAGNESIUM ION, ... Authors: De Nicola, G.F, Nichols, C.E. Deposit date: 2020-03-04 Release date: 2020-07-22 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.679 Å) Cite: Mining the PDB for Tractable Cases Where X-ray Crystallography Combined with Fragment Screens Can Be Used to Systematically Design Protein-Protein Inhibitors: Two Test Cases Illustrated by IL1 beta-IL1R and p38 alpha-TAB1 Complexes. J.Med.Chem., 63, 2020
5R9F	PanDDA analysis group deposition Form1 MAP kinase p38-alpha -- Fragment N13724a in complex with MAP kinase p38-alpha Descriptor: 2-(4-aminophenyl)benzoic acid, CHLORIDE ION, DIMETHYL SULFOXIDE, ... Authors: De Nicola, G.F, Nichols, C.E. Deposit date: 2020-03-04 Release date: 2020-07-22 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.986 Å) Cite: Mining the PDB for Tractable Cases Where X-ray Crystallography Combined with Fragment Screens Can Be Used to Systematically Design Protein-Protein Inhibitors: Two Test Cases Illustrated by IL1 beta-IL1R and p38 alpha-TAB1 Complexes. J.Med.Chem., 63, 2020
5R92	PanDDA analysis group deposition Form1 MAP kinase p38-alpha -- Fragment KCL063 in complex with MAP kinase p38-alpha Descriptor: (3~{S})-~{N}-methoxy-1-(4-methoxyphenyl)-~{N}-methyl-5-oxidanylidene-pyrrolidine-3-carboxamide, ACETATE ION, CHLORIDE ION, ... Authors: De Nicola, G.F, Nichols, C.E. Deposit date: 2020-03-04 Release date: 2020-07-22 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.66 Å) Cite: Mining the PDB for Tractable Cases Where X-ray Crystallography Combined with Fragment Screens Can Be Used to Systematically Design Protein-Protein Inhibitors: Two Test Cases Illustrated by IL1 beta-IL1R and p38 alpha-TAB1 Complexes. J.Med.Chem., 63, 2020
5R9I	PanDDA analysis group deposition Form1 MAP kinase p38-alpha -- Fragment TCJ795 in complex with MAP kinase p38-alpha Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, DIMETHYL SULFOXIDE, ... Authors: De Nicola, G.F, Nichols, C.E. Deposit date: 2020-03-04 Release date: 2020-07-22 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.813 Å) Cite: Mining the PDB for Tractable Cases Where X-ray Crystallography Combined with Fragment Screens Can Be Used to Systematically Design Protein-Protein Inhibitors: Two Test Cases Illustrated by IL1 beta-IL1R and p38 alpha-TAB1 Complexes. J.Med.Chem., 63, 2020
5R9W	PanDDA analysis group deposition Form1 MAP kinase p38-alpha -- Fragment N13598a in complex with MAP kinase p38-alpha Descriptor: CHLORIDE ION, DIMETHYL SULFOXIDE, MAGNESIUM ION, ... Authors: De Nicola, G.F, Nichols, C.E. Deposit date: 2020-03-04 Release date: 2020-07-22 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.89 Å) Cite: Mining the PDB for Tractable Cases Where X-ray Crystallography Combined with Fragment Screens Can Be Used to Systematically Design Protein-Protein Inhibitors: Two Test Cases Illustrated by IL1 beta-IL1R and p38 alpha-TAB1 Complexes. J.Med.Chem., 63, 2020

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