1MY3
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![BU of 1my3 by Molmil](/molmil-images/mine/1my3) | crystal structure of glutamate receptor ligand-binding core in complex with bromo-willardiine in the Zn crystal form | Descriptor: | 2-AMINO-3-(5-BROMO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-PROPIONIC ACID, GLUTAMATE RECEPTOR 2, ZINC ION | Authors: | Jin, R, Gouaux, E. | Deposit date: | 2002-10-03 | Release date: | 2003-06-10 | Last modified: | 2017-08-23 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Probing the Function, Conformational Plasticity, and Dimer-Dimer Contacts of the GluR2 Ligand-Binding Core:
Studies of 5-Substituted Willardiines and GluR2 S1S2 in the Crystal Biochemistry, 42, 2003
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5FA1
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![BU of 5fa1 by Molmil](/molmil-images/mine/5fa1) | The structure of the beta-3-deoxy-D-manno-oct-2-ulosonic acid transferase domain of WbbB | Descriptor: | CYTIDINE-5'-MONOPHOSPHATE, Putative N-acetyl glucosaminyl transferase | Authors: | Mallette, E, Ovchinnikova, O.G, Whitfield, C, Kimber, M.S. | Deposit date: | 2015-12-10 | Release date: | 2016-05-18 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Bacterial beta-Kdo glycosyltransferases represent a new glycosyltransferase family (GT99). Proc. Natl. Acad. Sci. U.S.A., 113, 2016
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5TDY
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![BU of 5tdy by Molmil](/molmil-images/mine/5tdy) | Structure of cofolded FliFc:FliGn complex from Thermotoga maritima | Descriptor: | Flagellar M-ring protein, Flagellar motor switch protein FliG | Authors: | Lynch, M.J, Levenson, R, Kim, E.A, Sircar, R, Blair, D.F, Dahlquist, F.W, Crane, B.R. | Deposit date: | 2016-09-20 | Release date: | 2017-01-25 | Last modified: | 2020-01-29 | Method: | X-RAY DIFFRACTION (2.105 Å) | Cite: | Co-Folding of a FliF-FliG Split Domain Forms the Basis of the MS:C Ring Interface within the Bacterial Flagellar Motor. Structure, 25, 2017
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7M0S
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![BU of 7m0s by Molmil](/molmil-images/mine/7m0s) | |
7LFS
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![BU of 7lfs by Molmil](/molmil-images/mine/7lfs) | Crystal structure of the epidermal growth factor receptor extracellular region with A265V mutation in complex with epiregulin | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Isoform 4 of Epidermal growth factor receptor, ... | Authors: | Hu, C, Leche II, C.A, Stayrook, S.E, Ferguson, K.M, Lemmon, M.A. | Deposit date: | 2021-01-18 | Release date: | 2021-11-17 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Glioblastoma mutations alter EGFR dimer structure to prevent ligand bias. Nature, 602, 2022
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7UPZ
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![BU of 7upz by Molmil](/molmil-images/mine/7upz) | Structural basis for cell type specific DNA binding of C/EBPbeta: the case of cell cycle inhibitor p15INK4b promoter | Descriptor: | CCAAT/enhancer-binding protein beta, DNA (5'-D(*AP*TP*TP*CP*TP*TP*AP*AP*GP*AP*AP*AP*GP*AP*CP*G)-3'), DNA (5'-D(*TP*CP*GP*TP*CP*TP*TP*TP*CP*TP*TP*AP*AP*GP*AP*A)-3') | Authors: | Lountos, G.T, Cherry, S, Tropea, J.E, Wlodawer, A, Miller, M. | Deposit date: | 2022-04-18 | Release date: | 2022-11-23 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.487 Å) | Cite: | Structural basis for cell type specific DNA binding of C/EBP beta : The case of cell cycle inhibitor p15INK4b promoter. J.Struct.Biol., 214, 2022
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4L81
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![BU of 4l81 by Molmil](/molmil-images/mine/4l81) | Structure of the SAM-I/IV riboswitch (env87(deltaU92, deltaG93)) | Descriptor: | COBALT HEXAMMINE(III), MAGNESIUM ION, S-ADENOSYLMETHIONINE, ... | Authors: | Trausch, J.J, Reyes, F.E, Edwards, A.L, Batey, R.T. | Deposit date: | 2013-06-15 | Release date: | 2014-05-28 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | Structural basis for diversity in the SAM clan of riboswitches. Proc.Natl.Acad.Sci.USA, 111, 2014
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1D2D
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![BU of 1d2d by Molmil](/molmil-images/mine/1d2d) | Hamster EprS second repeated element. NMR, 5 structures | Descriptor: | TRNA SYNTHETASE | Authors: | Cahuzac, B, Berthonneau, E, Birlirakis, N, Guittet, E, Mirande, M. | Deposit date: | 1999-09-23 | Release date: | 2000-05-24 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | A recurrent RNA-binding domain is appended to eukaryotic aminoacyl-tRNA synthetases. EMBO J., 19, 2000
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5YIG
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![BU of 5yig by Molmil](/molmil-images/mine/5yig) | Crystal structure of Streptococcus pneumonia ParE with inhibitor | Descriptor: | 1-ethyl-3-[5-[2-[(1S,5R)-3-methyl-3,8-diazabicyclo[3.2.1]octan-8-yl]-5-(2-oxidanylidene-3H-1,3,4-oxadiazol-5-yl)pyridin-3-yl]-4-[4-(trifluoromethyl)-1,3-thiazol-2-yl]pyridin-2-yl]urea, DNA topoisomerase 4 subunit B | Authors: | Cherian, J, Tan, Y, Hill, J. | Deposit date: | 2017-10-04 | Release date: | 2018-09-05 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Discovery of dual GyrB/ParE inhibitors active against Gram-negative bacteria. Eur J Med Chem, 157, 2018
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3M1N
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![BU of 3m1n by Molmil](/molmil-images/mine/3m1n) | Crystal structure of Human Sonic Hedgehog N-terminal domain | Descriptor: | SULFATE ION, Sonic hedgehog protein, ZINC ION | Authors: | Boriack-Sjodin, P.A, Pepinsky, R.B, Garber, E.A, Silvian, L.F. | Deposit date: | 2010-03-05 | Release date: | 2010-03-16 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Mapping sonic hedgehog-receptor interactions by steric interference. J.Biol.Chem., 275, 2000
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2Z81
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![BU of 2z81 by Molmil](/molmil-images/mine/2z81) | Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide | Descriptor: | (2R)-3-{[(2S)-3-HYDROXY-2-(PALMITOYLAMINO)PROPYL]THIO}PROPANE-1,2-DIYL DIHEXADECANOATE, 2-acetamido-2-deoxy-beta-D-glucopyranose, Toll-like receptor 2, ... | Authors: | Lee, J.O, Jin, M.S, Kim, S.E, Heo, J.Y. | Deposit date: | 2007-08-30 | Release date: | 2007-10-02 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal Structure of the TLR1-TLR2 Heterodimer Induced by Binding of a Tri-Acylated Lipopeptide Cell(Cambridge,Mass.), 130, 2007
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1XLV
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![BU of 1xlv by Molmil](/molmil-images/mine/1xlv) | Ethylphosphorylated Butyrylcholinesterase (Aged) Obtained By Reaction With Echothiophate | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Nachon, F, Asojo, O.A, Borgstahl, G.E.O, Masson, P, Lockridge, O. | Deposit date: | 2004-09-30 | Release date: | 2005-02-01 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.247 Å) | Cite: | Role of Water in Aging of Human Butyrylcholinesterase Inhibited by Echothiophate: The Crystal Structure Suggests Two Alternative Mechanisms of Aging Biochemistry, 44, 2005
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1C52
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![BU of 1c52 by Molmil](/molmil-images/mine/1c52) | THERMUS THERMOPHILUS CYTOCHROME-C552: A NEW HIGHLY THERMOSTABLE CYTOCHROME-C STRUCTURE OBTAINED BY MAD PHASING | Descriptor: | CYTOCHROME-C552, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Than, M.E, Hof, P, Huber, R, Bourenkov, G.P, Bartunik, H.D, Buse, G, Soulimane, T. | Deposit date: | 1997-06-23 | Release date: | 1998-06-24 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.28 Å) | Cite: | Thermus thermophilus cytochrome-c552: A new highly thermostable cytochrome-c structure obtained by MAD phasing. J.Mol.Biol., 271, 1997
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6AVP
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![BU of 6avp by Molmil](/molmil-images/mine/6avp) | Staphylococcus aureus Type II pantothenate kinase in complex with ADP and pantothenate analog Phosphate-MeO-N5Pan | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, N~3~-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-N-(5-methoxypentyl)-beta-alaninamide, ... | Authors: | Chen, Y, Antoshchenko, T, Strauss, E, Barnard, L, Huang, Y.H. | Deposit date: | 2017-09-04 | Release date: | 2018-09-12 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure-based identification of uncompetitive inhibitors for Staphylococcus aureus pantothenate kinase. To Be Published
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7LRZ
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![BU of 7lrz by Molmil](/molmil-images/mine/7lrz) | Structure of the Human ALK GRD | Descriptor: | ALK tyrosine kinase receptor | Authors: | Stayrook, S, Li, T, Klein, D.E. | Deposit date: | 2021-02-17 | Release date: | 2021-11-24 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.91 Å) | Cite: | Structural basis for ligand reception by anaplastic lymphoma kinase. Nature, 600, 2021
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6AWG
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![BU of 6awg by Molmil](/molmil-images/mine/6awg) | Staphylococcus aureus Type II pantothenate kinase in complex with nucleotides and pantothenate analog Deoxy-N190Pan | Descriptor: | (2R)-N-(3-{[(2H-1,3-benzodioxol-5-yl)methyl]amino}-3-oxopropyl)-2-hydroxy-3,3-dimethylbutanamide, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ... | Authors: | Chen, Y, Antoshchenko, T, Strauss, E, Barnard, L, Huang, Y.H. | Deposit date: | 2017-09-05 | Release date: | 2018-09-12 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structure-based identification of uncompetitive inhibitors for Staphylococcus aureus pantothenate kinase. To Be Published
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6AX9
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![BU of 6ax9 by Molmil](/molmil-images/mine/6ax9) | F95N Epi-isozizaene synthase | Descriptor: | Epi-isozizaene synthase, MAGNESIUM ION, N-benzyl-N,N-diethylethanaminium, ... | Authors: | Blank, P.N, Barrow, G.H, Christianson, D.W. | Deposit date: | 2017-09-06 | Release date: | 2017-10-18 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.403 Å) | Cite: | Substitution of Aromatic Residues with Polar Residues in the Active Site Pocket of epi-Isozizaene Synthase Leads to the Generation of New Cyclic Sesquiterpenes. Biochemistry, 56, 2017
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7UJX
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![BU of 7ujx by Molmil](/molmil-images/mine/7ujx) | Structure of cAMP-dependent protein kinase using a MD-MX procedure, produced using 2.4 Angstrom data | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHATE ION, ... | Authors: | Wych, D.C, Aoto, P.C, Wall, M.E. | Deposit date: | 2022-03-31 | Release date: | 2022-12-07 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Molecular-dynamics simulation methods for macromolecular crystallography. Acta Crystallogr D Struct Biol, 79, 2023
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1YF6
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![BU of 1yf6 by Molmil](/molmil-images/mine/1yf6) | Structure of a quintuple mutant of photosynthetic reaction center from rhodobacter sphaeroides | Descriptor: | BACTERIOCHLOROPHYLL A, BACTERIOPHEOPHYTIN A, CARDIOLIPIN, ... | Authors: | Paddock, M.L, Chang, C, Xu, Q, Abresch, E.C, Axelrod, H.L. | Deposit date: | 2004-12-30 | Release date: | 2005-05-17 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Quinone (Q(B)) Reduction by B-Branch Electron Transfer in Mutant Bacterial Reaction Centers from Rhodobacter sphaeroides: Quantum Efficiency and X-ray Structure. Biochemistry, 44, 2005
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4KWU
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![BU of 4kwu by Molmil](/molmil-images/mine/4kwu) | 1.9 Angstrom resolution crystal structure of uncharacterized protein lmo2446 from Listeria monocytogenes EGD-e in complex with alpha-D-glucose, beta-D-glucose, magnesium and calcium | Descriptor: | CALCIUM ION, Lmo2446 protein, MAGNESIUM ION, ... | Authors: | Halavaty, A.S, Minasov, G, Dubrovska, I, Winsor, J, Shuvalova, L, Peterson, S, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2013-05-24 | Release date: | 2013-06-19 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | 1.9 Angstrom resolution crystal structure of uncharacterized protein lmo2446 from Listeria monocytogenes EGD-e in complex with alpha-D-glucose, beta-D-glucose, magnesium and calcium To be Published
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4BX9
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![BU of 4bx9 by Molmil](/molmil-images/mine/4bx9) | Human Vps33A in complex with a fragment of human Vps16 | Descriptor: | (2S)-2-hydroxybutanedioic acid, FORMIC ACID, MALONIC ACID, ... | Authors: | Graham, S.C, Wartosch, L, Gray, S.R, Scourfield, E.J, Deane, J.E, Luzio, J.P, Owen, D.J. | Deposit date: | 2013-07-09 | Release date: | 2013-07-24 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural basis of Vps33A recruitment to the human HOPS complex by Vps16. Proc. Natl. Acad. Sci. U.S.A., 110, 2013
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1T7D
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![BU of 1t7d by Molmil](/molmil-images/mine/1t7d) | Crystal structure of Escherichia coli type I signal peptidase in complex with a lipopeptide inhibitor | Descriptor: | 10-METHYLUNDECANOIC ACID, ARYLOMYCIN A2, SIGNAL PEPTIDASE I | Authors: | Paetzel, M, Goodall, J.J, Kania, M, Dalbey, R.E, Page, M.G.P. | Deposit date: | 2004-05-09 | Release date: | 2004-07-13 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.47 Å) | Cite: | Crystallographic and Biophysical Analysis of a Bacterial Signal Peptidase in Complex with a Lipopeptide Based Inhibitor. J.Biol.Chem., 279, 2004
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4PN3
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![BU of 4pn3 by Molmil](/molmil-images/mine/4pn3) | Crystal structure of 3-hydroxyacyl-CoA-dehydrogenase from Brucella melitensis | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 3-hydroxyacyl-CoA dehydrogenase | Authors: | Lukacs, C.M, Abendroth, J, Edwards, T.E, Lorimer, D, Seattle Structural Genomics Center for Infectious Disease (SSGCID) | Deposit date: | 2014-05-22 | Release date: | 2014-06-25 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Crystal structure of 3-hydroxyacyl-CoA-dehydrogenase from Brucella melitensis To Be Published
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7V0G
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![BU of 7v0g by Molmil](/molmil-images/mine/7v0g) | Structure of cAMP-dependent protein kinase using a MD-MX procedure, produced using 1.63 Angstrom data | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHATE ION, ... | Authors: | Wych, D.C, Aoto, P.C, Wall, M.E. | Deposit date: | 2022-05-10 | Release date: | 2022-12-07 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.63 Å) | Cite: | Molecular-dynamics simulation methods for macromolecular crystallography. Acta Crystallogr D Struct Biol, 79, 2023
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5QFE
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![BU of 5qfe by Molmil](/molmil-images/mine/5qfe) | PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOOA000509a | Descriptor: | (2S,5S,6R)-7-methyl-2,3,4,5,6,7-hexahydro-1H-2,6-methanoazocino[5,4-b]indol-5-ol, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Tyrosine-protein phosphatase non-receptor type 1 | Authors: | Keedy, D.A, Hill, Z.B, Biel, J.T, Kang, E, Rettenmaier, T.J, Brandao-Neto, J, von Delft, F, Wells, J.A, Fraser, J.S. | Deposit date: | 2018-08-30 | Release date: | 2018-10-10 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.563 Å) | Cite: | An expanded allosteric network in PTP1B by multitemperature crystallography, fragment screening, and covalent tethering. Elife, 7, 2018
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