2Z81

Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide

Summary for 2Z81

• Entry DOI: 10.2210/pdb2z81/pdb
• Related: 2Z7X 2Z80 2Z82
• Descriptor: Toll-like receptor 2, Variable lymphocyte receptor B, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• Functional Keywords: tlr2, pam3csk4, lipopeptide, innate immunity, cytoplasmic vesicle, glycoprotein, immune response, inflammatory response, leucine-rich repeat, membrane, receptor, transmembrane, immune system
• Biological source: Mus musculus (house mouse, inshore hagfish); More
• Total number of polymer chains: 1
• Total formula weight: 64263.73

Authors

Lee, J.O.,Jin, M.S.,Kim, S.E.,Heo, J.Y. (deposition date: 2007-08-30, release date: 2007-10-02, Last modification date: 2023-11-01)

• Primary citation: Jin, M.S.,Kim, S.E.,Heo, J.Y.,Lee, M.E.,Kim, H.M.,Paik, S.G.,Lee, H.,Lee, J.O.; Crystal Structure of the TLR1-TLR2 Heterodimer Induced by Binding of a Tri-Acylated Lipopeptide; Cell(Cambridge,Mass.), 130:1071-1082, 2007; PubMed: 17889651; DOI: 10.1016/j.cell.2007.09.008

Experimental method

X-RAY DIFFRACTION (1.8 Å)