2Z81
Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Toll-like receptor 2, Variable lymphocyte receptor B | polymer | 549 | 61973.0 | 1 | UniProt (Q9QUN7) UniProt (Q4G1L2) Pfam (PF13516) Pfam (PF13855) | Mus musculus (house mouse inshore hagfish) | CD282 antigen |
| 2 | B (B) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) | |||
| 3 | C (C) | alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G62182OO) | |||
| 4 | D (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 5 | E (A) | (2R)-3-{[(2S)-3-HYDROXY-2-(PALMITOYLAMINO)PROPYL]THIO}PROPANE-1,2-DIYL DIHEXADECANOATE | non-polymer | 896.5 | 1 | Chemie (PCJ) | |||
| 6 | F (A) | water | water | 18.0 | 312 | Chemie (HOH) |
Sequence modifications
A: 27 - 506 (UniProt: Q9QUN7)
A: 509 - 575 (UniProt: Q4G1L2)
| PDB | External Database | Details |
|---|---|---|
| Ser 507 | - | linker |
| Arg 508 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 61973.0 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 1173.1 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1117.7 | |
| All* | Total formula weight | 64263.7 |
