5IBC
 
 | | Caspase 3 V266I | | Descriptor: | ACE-ASP-GLU-VAL-ASK, Caspase-3, SODIUM ION | | Authors: | Maciag, J.J, Mackenzie, S.H, Tucker, M.B, Schipper, J.L, Swartz, P.D, Clark, A.C. | | Deposit date: | 2016-02-22 | | Release date: | 2016-10-26 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (1.66 Å) | | Cite: | Tunable allosteric library of caspase-3 identifies coupling between conserved water molecules and conformational selection.
Proc.Natl.Acad.Sci.USA, 113, 2016
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4FXO
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4DCO
 | | Crystal Structure of caspase 3, L168Y mutant | | Descriptor: | Caspase Inhibitor AC-DEVD-CHO, Caspase-3 subunit p12, Caspase-3 subunit p17 | | Authors: | Chung, S.J, Kang, H.J, Kim, S.J. | | Deposit date: | 2012-01-18 | | Release date: | 2012-12-12 | | Last modified: | 2025-03-26 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Molecular insight into the role of the leucine residue on the L2 loop in the catalytic activity of caspases 3 and 7
Biosci.Rep., 32, 2012
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3P45
 | | Crystal structure of apo-caspase-6 at physiological pH | | Descriptor: | caspase-6 | | Authors: | Mueller, I, Lamers, M.B.A.C, Ritchie, A.J, Dominguez, C, Munoz, I, Maillard, M, Kiselyov, A. | | Deposit date: | 2010-10-06 | | Release date: | 2011-06-15 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.53 Å) | | Cite: | Crystal structures of active and inhibitor-bound human Casp6
To be Published
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4EHD
 | | Allosteric Modulation of Caspase-3 through Mutagenesis | | Descriptor: | ACE-ASP-GLU-VAL-ASP-CHLOROMETHYLKETONE INHIBITOR, Caspase-3 | | Authors: | Walters, J, Schipper, J.L, Swartz, P, Mattos, C, Clark, A.C. | | Deposit date: | 2012-04-02 | | Release date: | 2012-06-06 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (1.581 Å) | | Cite: | Allosteric modulation of caspase 3 through mutagenesis.
Biosci.Rep., 32, 2012
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3R5K
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3RJM
 | | CASPASE2 IN COMPLEX WITH CHDI LIGAND 33c | | Descriptor: | Caspase-2, Peptide inhibitor (ACE)VDV(3PX)D-CHO | | Authors: | Abendroth, J, Lorimer, D, Stewart, L, Maillard, M, Kiselyov, A.S. | | Deposit date: | 2011-04-15 | | Release date: | 2011-09-21 | | Last modified: | 2023-12-06 | | Method: | X-RAY DIFFRACTION (2.55 Å) | | Cite: | Exploiting differences in caspase-2 and -3 S(2) subsites for selectivity: Structure-based design, solid-phase synthesis and in vitro activity of novel substrate-based caspase-2 inhibitors.
Bioorg.Med.Chem., 19, 2011
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3R6G
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3R7S
 | | Crystal Structure of Apo Caspase2 | | Descriptor: | Caspase-2 subunit p12, Caspase-2 subunit p18 | | Authors: | Tang, Y, Wells, J, Arkin, M. | | Deposit date: | 2011-03-22 | | Release date: | 2011-07-27 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2.252 Å) | | Cite: | Structural and enzymatic insights into caspase-2 protein substrate recognition and catalysis.
J.Biol.Chem., 286, 2011
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5JFT
 | | Zebra Fish Caspase-3 | | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, ACE-ASP-GLU-VAL-ASK, ... | | Authors: | Tucker, M.B, MacKenzie, S.H, Maciag, J.J, Dirscherl, H, Swartz, P.D, Yoder, J.A, Hamilton, P.T, Clark, A.C. | | Deposit date: | 2016-04-19 | | Release date: | 2016-10-26 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (2.28 Å) | | Cite: | Phage display and structural studies reveal plasticity in substrate specificity of caspase-3a from zebrafish.
Protein Sci., 25, 2016
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3R5J
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3R6L
 | | Caspase-2 T380A bound with Ac-VDVAD-CHO | | Descriptor: | Caspase-2 subunit p12, Caspase-2 subunit p18, Peptide Inhibitor (ACE)VDVAD-CHO | | Authors: | Tang, Y, Wells, J, Arkin, M. | | Deposit date: | 2011-03-21 | | Release date: | 2011-07-27 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structural and enzymatic insights into caspase-2 protein substrate recognition and catalysis.
J.Biol.Chem., 286, 2011
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3R7B
 | | Caspase-2 bound to one copy of Ac-DVAD-CHO | | Descriptor: | Caspase-2 subunit p12, Caspase-2 subunit p18, Peptide Inhibitor (ACE)DVAD-CHO | | Authors: | Tang, Y, Wells, J, Arkin, M. | | Deposit date: | 2011-03-22 | | Release date: | 2011-07-27 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structural and enzymatic insights into caspase-2 protein substrate recognition and catalysis.
J.Biol.Chem., 286, 2011
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3OD5
 | | Crystal structure of active caspase-6 bound with Ac-VEID-CHO | | Descriptor: | CACODYLATE ION, Caspase-6, peptide aldehyde inhibitor AC-VEID-CHO | | Authors: | Wang, X.-J, Liu, X, Wang, K.-T, Cao, Q, Su, X.-D. | | Deposit date: | 2010-08-11 | | Release date: | 2010-10-27 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Crystal structures of human caspase 6 reveal a new mechanism for intramolecular cleavage self-activation
Embo Rep., 11, 2010
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4DCJ
 | | Crystal structure of caspase 3, L168D mutant | | Descriptor: | Caspase Inhibitor AC-DEVD-CHO, Caspase-3 subunit p12, Caspase-3 subunit p17 | | Authors: | Chung, S.J, Kang, H.J, Kim, S.J. | | Deposit date: | 2012-01-17 | | Release date: | 2012-12-12 | | Last modified: | 2025-03-26 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Molecular insight into the role of the leucine residue on the L2 loop in the catalytic activity of caspases 3 and 7
Biosci.Rep., 32, 2012
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3R7N
 | | Caspase-2 bound with two copies of Ac-DVAD-CHO | | Descriptor: | Caspase-2 subunit p12, Caspase-2 subunit p18, Peptide Inhibitor (ACE)DVAD-CHO | | Authors: | Tang, Y, Wells, J, Arkin, M. | | Deposit date: | 2011-03-22 | | Release date: | 2011-07-27 | | Last modified: | 2024-11-27 | | Method: | X-RAY DIFFRACTION (2.33 Å) | | Cite: | Structural and enzymatic insights into caspase-2 protein substrate recognition and catalysis.
J.Biol.Chem., 286, 2011
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3PD0
 | | Caspase-3 E246A | | Descriptor: | CHLORIDE ION, Caspase-3, INHIBITOR AC-DEVD-CMK | | Authors: | Walters, J, Swartz, P, Mattos, C, Clark, A.C. | | Deposit date: | 2010-10-22 | | Release date: | 2011-02-16 | | Last modified: | 2024-11-27 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Thermodynamic, enzymatic and structural effects of removing a salt bridge at the base of loop 4 in (pro)caspase-3.
Arch.Biochem.Biophys., 508, 2011
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2CJY
 | | Extended substrate recognition in caspase-3 revealed by high resolution X-ray structure analysis | | Descriptor: | CASPASE-3, PHQ-ASP-GLU-VAL-ASP-CHLOROMETHYLKETONE | | Authors: | Ganesan, R, Mittl, P.R.E, Jelakovic, S, Grutter, M.G. | | Deposit date: | 2006-04-09 | | Release date: | 2006-06-27 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (1.67 Å) | | Cite: | Extended Substrate Recognition in Caspase-3 Revealed by High Resolution X-Ray Structure Analysis
J.Mol.Biol., 359, 2006
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2FP3
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2FQQ
 | | Crystal structure of human caspase-1 (Cys285->Ala, Cys362->Ala, Cys364->Ala, Cys397->Ala) in complex with 1-methyl-3-trifluoromethyl-1H-thieno[2,3-c]pyrazole-5-carboxylic acid (2-mercapto-ethyl)-amide | | Descriptor: | 1-METHYL-3-TRIFLUOROMETHYL-1H-THIENO[2,3-C]PYRAZOLE-5-CARBOXYLIC ACID (2-MERCAPTO-ETHYL)-AMIDE, Caspase-1 | | Authors: | Scheer, J.M, Wells, J.A, Romanowski, M.J. | | Deposit date: | 2006-01-18 | | Release date: | 2006-05-16 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | A common allosteric site and mechanism in caspases
Proc.Natl.Acad.Sci.USA, 103, 2006
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2H4Y
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2H51
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2H5J
 | | Crystal strusture of caspase-3 with inhibitor Ac-DMQD-Cho | | Descriptor: | Ac-DMQD-Cho, caspase-3, p12 subunit, ... | | Authors: | Fang, B, Boross, P.I, Tozser, J, Weber, I.T. | | Deposit date: | 2006-05-26 | | Release date: | 2006-09-19 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structural and kinetic analysis of caspase-3 reveals role for s5 binding site in substrate recognition
J.Mol.Biol., 360, 2006
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2H5I
 | | Crystal structure of caspase-3 with inhibitor Ac-DEVD-Cho | | Descriptor: | Ac-DEV(ASJ), caspase-3, p12 subunit, ... | | Authors: | Fang, B, Boross, P.I, Tozser, J, Weber, I.T. | | Deposit date: | 2006-05-26 | | Release date: | 2006-09-19 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (1.69 Å) | | Cite: | Structural and kinetic analysis of caspase-3 reveals role for s5 binding site in substrate recognition
J.Mol.Biol., 360, 2006
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2HBQ
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