2H5I

Crystal structure of caspase-3 with inhibitor Ac-DEVD-Cho

Summary for 2H5I

• Entry DOI: 10.2210/pdb2h5i/pdb
• Related: 2H5J 2H65
• Related PRD ID: PRD_000422
• Descriptor: caspase-3, p17 subunit, caspase-3, p12 subunit, Ac-DEV(ASJ), ... (4 entities in total)
• Functional Keywords: enzyme catalysis, cysteine protease, apoptosis, induced fit, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human); More
• Cellular location: Cytoplasm: P42574 P42574
• Total number of polymer chains: 3
• Total formula weight: 28271.26

Authors

Fang, B.,Boross, P.I.,Tozser, J.,Weber, I.T. (deposition date: 2006-05-26, release date: 2006-09-19, Last modification date: 2023-11-15)

• Primary citation: Fang, B.,Boross, P.I.,Tozser, J.,Weber, I.T.; Structural and kinetic analysis of caspase-3 reveals role for s5 binding site in substrate recognition; J.Mol.Biol., 360:654-666, 2006; PubMed: 16781734; DOI: 10.1016/j.jmb.2006.05.041

Experimental method

X-RAY DIFFRACTION (1.69 Å)