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PDB: 280 results
4YFK
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BU of 4yfk by Molmil
Escherichia coli RNA polymerase in complex with squaramide compound 8.
Descriptor: 3,5-dimethyl-N-{2-[4-(4-methylbenzyl)piperidin-1-yl]-3,4-dioxocyclobut-1-en-1-yl}-1,2-oxazole-4-sulfonamide, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
Authors:Molodtsov, V, Fleming, P.R, Eyermann, C.J, Ferguson, A.D, Foulk, M.A, McKinney, D.C, Masse, C.E, Buurman, E.T, Murakami, K.S.
Deposit date:2015-02-25
Release date:2015-03-11
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.571 Å)
Cite:X-ray Crystal Structures of Escherichia coli RNA Polymerase with Switch Region Binding Inhibitors Enable Rational Design of Squaramides with an Improved Fraction Unbound to Human Plasma Protein.
J.Med.Chem., 58, 2015
4YFN
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BU of 4yfn by Molmil
Escherichia coli RNA polymerase in complex with squaramide compound 14 (N-[3,4-dioxo-2-(4-{[4-(trifluoromethyl)benzyl]amino}piperidin-1-yl)cyclobut-1-en-1-yl]-3,5-dimethyl-1,2-oxazole-4-sulfonamide)
Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Molodtsov, V, Fleming, P.R, Eyermann, C.J, Ferguson, A.D, Foulk, M.A, McKinney, D.C, Masse, C.E, Buurman, E.T, Murakami, K.S.
Deposit date:2015-02-25
Release date:2015-03-11
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.817 Å)
Cite:X-ray Crystal Structures of Escherichia coli RNA Polymerase with Switch Region Binding Inhibitors Enable Rational Design of Squaramides with an Improved Fraction Unbound to Human Plasma Protein.
J.Med.Chem., 58, 2015
4ZH2
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BU of 4zh2 by Molmil
Crystal structure of Escherichia coli RNA polymerase in complex with CBR703
Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Feng, Y, Ebright, R.H.
Deposit date:2015-04-24
Release date:2015-08-05
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (4.204 Å)
Cite:Structural Basis of Transcription Inhibition by CBR Hydroxamidines and CBR Pyrazoles.
Structure, 23, 2015
4ZH3
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BU of 4zh3 by Molmil
Crystal structure of Escherichia coli RNA polymerase in complex with CBRH16-Br
Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Feng, Y, Ebright, R.H.
Deposit date:2015-04-24
Release date:2015-08-05
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (4.082 Å)
Cite:Structural Basis of Transcription Inhibition by CBR Hydroxamidines and CBR Pyrazoles.
Structure, 23, 2015
4ZH4
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BU of 4zh4 by Molmil
Crystal structure of Escherichia coli RNA polymerase in complex with CBRP18
Descriptor: 5-(4-fluorophenyl)-4-[4-fluoro-3-(trifluoromethyl)phenyl]-1H-pyrazole, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
Authors:Feng, Y, Ebright, R.H.
Deposit date:2015-04-24
Release date:2015-08-05
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.993 Å)
Cite:Structural Basis of Transcription Inhibition by CBR Hydroxamidines and CBR Pyrazoles.
Structure, 23, 2015
4JKR
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BU of 4jkr by Molmil
Crystal Structure of E. coli RNA Polymerase in complex with ppGpp
Descriptor: DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA', DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
Authors:Zuo, Y, Wang, Y, Steitz, T.A.
Deposit date:2013-03-11
Release date:2013-05-15
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (4.2 Å)
Cite:The mechanism of E. coli RNA polymerase regulation by ppGpp is suggested by the structure of their complex.
Mol.Cell, 50, 2013
4JK1
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BU of 4jk1 by Molmil
X-ray crystal structure of Escherichia coli sigma70 holoenzyme in complex with Guanosine tetraphosphate (ppGpp)
Descriptor: Escherichia coli RNA polymerase alpha subunit, Escherichia coli RNA polymerase beta subunit, Escherichia coli RNA polymerase beta' subunit, ...
Authors:Murakami, K.S.
Deposit date:2013-03-09
Release date:2013-04-10
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3.9 Å)
Cite:Differential regulation by ppGpp versus pppGpp in Escherichia coli.
Nucleic Acids Res., 41, 2013
4JK2
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BU of 4jk2 by Molmil
X-ray crystal structure of Escherichia coli sigma70 holoenzyme in complex with guanosine pentaphosphate (pppGpp)
Descriptor: Escherichia coli RNA polymerase alpha subunit, Escherichia coli RNA polymerase beta subunit, Escherichia coli RNA polymerase beta' subunit, ...
Authors:Murakami, K.S.
Deposit date:2013-03-09
Release date:2013-04-17
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (4.201 Å)
Cite:Differential regulation by ppGpp versus pppGpp in Escherichia coli.
Nucleic Acids Res., 41, 2013
4KI2
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BU of 4ki2 by Molmil
Crystallographic analysis of an RNA-polymerase sigma-subunit fragment complexed with -10 promoter element ssDNA
Descriptor: DNA (5'-D(*TP*GP*TP*AP*CP*AP*AP*TP*GP*GP*G)-3'), POTASSIUM ION, RNA polymerase sigma factor
Authors:Feklistov, A, Darst, S.A.
Deposit date:2013-05-01
Release date:2013-09-04
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Crystallographic analysis of an RNA polymerase sigma-subunit fragment complexed with -10 promoter element ssDNA: quadruplex formation as a possible tool for engineering crystal contacts in protein-ssDNA complexes.
Acta Crystallogr.,Sect.F, 69, 2013
4KMU
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BU of 4kmu by Molmil
X-ray crystal structure of the Escherichia coli RNA polymerase in complex with Rifampin
Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Murakami, K.S.
Deposit date:2013-05-08
Release date:2013-05-22
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.85 Å)
Cite:X-ray Crystal Structures of the Escherichia coli RNA Polymerase in Complex with Benzoxazinorifamycins.
J.Med.Chem., 56, 2013
5D4D
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BU of 5d4d by Molmil
Crystal structure of Thermus thermophilus product complex for transcription initiation with NAD and CTP
Descriptor: ADENOSINE MONOPHOSPHATE, CYTIDINE-5'-MONOPHOSPHATE, CYTIDINE-5'-TRIPHOSPHATE, ...
Authors:Zhang, Y, Ebright, R.H.
Deposit date:2015-08-07
Release date:2016-07-06
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (3 Å)
Cite:The mechanism of RNA 5' capping with NAD(+), NADH and desphospho-CoA.
Nature, 535, 2016
4KN4
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BU of 4kn4 by Molmil
X-ray crystal structure of the Escherichia coli RNA polymerase in complex with Benzoxazinorifamycin-2b
Descriptor: Benzoxazinorifamycin-2b, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
Authors:Murakami, K.S.
Deposit date:2013-05-08
Release date:2013-05-22
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.965 Å)
Cite:X-ray Crystal Structures of the Escherichia coli RNA Polymerase in Complex with Benzoxazinorifamycins.
J.Med.Chem., 56, 2013
4KN7
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BU of 4kn7 by Molmil
X-ray crystal structure of the Escherichia coli RNA polymerase in complex with Benzoxazinorifamycin-2c
Descriptor: Benzoxazinorifamycin-2c, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
Authors:Murakami, K.S.
Deposit date:2013-05-08
Release date:2013-05-22
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.686 Å)
Cite:X-ray Crystal Structures of the Escherichia coli RNA Polymerase in Complex with Benzoxazinorifamycins.
J.Med.Chem., 56, 2013
5D4C
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BU of 5d4c by Molmil
Crystal structure of Thermus thermophilus product complex for transcription initiation with ATP and CTP
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CYTIDINE-5'-MONOPHOSPHATE, CYTIDINE-5'-TRIPHOSPHATE, ...
Authors:Zhang, Y, Ebright, R.H.
Deposit date:2015-08-07
Release date:2016-07-06
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.28 Å)
Cite:The mechanism of RNA 5' capping with NAD(+), NADH and desphospho-CoA.
Nature, 535, 2016
4LK1
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BU of 4lk1 by Molmil
Crystal Structure Analysis of the E.coli holoenzyme
Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Bae, B, Darst, S.A.
Deposit date:2013-07-05
Release date:2013-11-13
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3.8369 Å)
Cite:Phage T7 Gp2 inhibition of Escherichia coli RNA polymerase involves misappropriation of sigma 70 domain 1.1.
Proc.Natl.Acad.Sci.USA, 110, 2013
4LLG
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BU of 4llg by Molmil
Crystal Structure Analysis of the E.coli holoenzyme/Gp2 complex
Descriptor: Bacterial RNA polymerase inhibitor, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
Authors:Bae, B, Darst, S.A.
Deposit date:2013-07-09
Release date:2013-11-13
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3.7936 Å)
Cite:Phage T7 Gp2 inhibition of Escherichia coli RNA polymerase involves misappropriation of sigma 70 domain 1.1.
Proc.Natl.Acad.Sci.USA, 110, 2013
4LJZ
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BU of 4ljz by Molmil
Crystal Structure Analysis of the E.coli holoenzyme
Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Bae, B, Darst, S.A.
Deposit date:2013-07-05
Release date:2013-11-13
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3.5871 Å)
Cite:Phage T7 Gp2 inhibition of Escherichia coli RNA polymerase involves misappropriation of sigma 70 domain 1.1.
Proc.Natl.Acad.Sci.USA, 110, 2013
4LK0
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BU of 4lk0 by Molmil
Crystal Structure Analysis of the E.coli holoenzyme/T7 Gp2 complex
Descriptor: Bacterial RNA polymerase inhibitor, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
Authors:Bae, B, Darst, S.A.
Deposit date:2013-07-05
Release date:2013-11-13
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3.9103 Å)
Cite:Phage T7 Gp2 inhibition of Escherichia coli RNA polymerase involves misappropriation of sigma 70 domain 1.1.
Proc.Natl.Acad.Sci.USA, 110, 2013
7KHE
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BU of 7khe by Molmil
Escherichia coli RNA polymerase and rrnBP1 promoter pre-open complex with DksA/ppGpp
Descriptor: CHAPSO, DNA (46-MER), DNA (54-MER), ...
Authors:Shin, Y, Qayyum, M.Z, Murakami, K.S.
Deposit date:2020-10-21
Release date:2020-12-09
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.58 Å)
Cite:Structural basis of ribosomal RNA transcription regulation.
Nat Commun, 12, 2021
7KHB
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BU of 7khb by Molmil
Escherichia coli RNA polymerase and rrnBP1 promoter open complex
Descriptor: CHAPSO, DNA (60-MER), DNA (64-MER), ...
Authors:Shin, Y, Qayyum, M.Z, Murakami, K.S.
Deposit date:2020-10-20
Release date:2020-10-28
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.53 Å)
Cite:Structural basis of ribosomal RNA transcription regulation.
Nat Commun, 12, 2021
7KHC
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BU of 7khc by Molmil
Escherichia coli RNA polymerase and rrnBP1 promoter closed complex
Descriptor: CHAPSO, DNA (18 MER), DNA (63-MER), ...
Authors:Shin, Y, Qayyum, M.Z, Murakami, K.S.
Deposit date:2020-10-20
Release date:2020-10-28
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (4.14 Å)
Cite:Structural basis of ribosomal RNA transcription regulation.
Nat Commun, 12, 2021
7KHI
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BU of 7khi by Molmil
Escherichia coli RNA polymerase and rrnBP1 promoter complex with DksA/ppGpp
Descriptor: CHAPSO, DNA (28-MER), DNA (36-MER), ...
Authors:Shin, Y, Qayyum, M.Z, Murakami, K.S.
Deposit date:2020-10-21
Release date:2020-10-28
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.62 Å)
Cite:Structural basis of ribosomal RNA transcription regulation.
Nat Commun, 12, 2021
7KIF
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BU of 7kif by Molmil
Mycobacterium tuberculosis WT RNAP transcription open promoter complex with WhiB7 transcription factor
Descriptor: DNA (55-MER), DNA (63-MER), DNA-directed RNA polymerase subunit alpha, ...
Authors:Lilic, M, Darst, S.A, Campbell, E.A.
Deposit date:2020-10-23
Release date:2021-04-21
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (2.94 Å)
Cite:Structural basis of transcriptional activation by the Mycobacterium tuberculosis intrinsic antibiotic-resistance transcription factor WhiB7.
Mol.Cell, 81, 2021
7KIN
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BU of 7kin by Molmil
Mycobacterium tuberculosis WT RNAP transcription open promoter complex with WhiB7 promoter
Descriptor: DNA (49-MER), DNA (54-MER), DNA-directed RNA polymerase subunit alpha, ...
Authors:Lilic, M, Darst, S.A, Campbell, E.A.
Deposit date:2020-10-23
Release date:2021-04-21
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (2.74 Å)
Cite:Structural basis of transcriptional activation by the Mycobacterium tuberculosis intrinsic antibiotic-resistance transcription factor WhiB7.
Mol.Cell, 81, 2021
7KIM
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BU of 7kim by Molmil
Mycobacterium tuberculosis WT RNAP transcription closed promoter complex with WhiB7 transcription factor
Descriptor: DNA (45-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
Authors:Lilic, M, Darst, S.A, Campbell, E.A.
Deposit date:2020-10-23
Release date:2021-04-21
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (3.38 Å)
Cite:Structural basis of transcriptional activation by the Mycobacterium tuberculosis intrinsic antibiotic-resistance transcription factor WhiB7.
Mol.Cell, 81, 2021

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