4V6W
| Structure of the D. melanogaster 80S ribosome | Descriptor: | 18S ribosomal RNA, 28S ribosomal RNA, 2S ribosomal RNA, ... | Authors: | Anger, A.M, Armache, J.-P, Berninghausen, O, Habeck, M, Subklewe, M, Wilson, D.N, Beckmann, R. | Deposit date: | 2013-02-27 | Release date: | 2014-07-09 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (6 Å) | Cite: | Structures of the human and Drosophila 80S ribosome. Nature, 497, 2013
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4V8M
| High-resolution cryo-electron microscopy structure of the Trypanosoma brucei ribosome | Descriptor: | 18S RRNA OF THE SMALL RIBOSOMAL SUBUNIT, 40S RIBOSOMAL PROTEIN S10, PUTATIVE, ... | Authors: | Hashem, Y, des Georges, A, Fu, J, Buss, S.N, Jossinet, F, Jobe, A, Zhang, Q, Liao, H.Y, Grassucci, R.A, Bajaj, C, Westhof, E, Madison-Antenucci, S, Frank, J. | Deposit date: | 2012-12-09 | Release date: | 2014-07-09 | Last modified: | 2019-12-11 | Method: | ELECTRON MICROSCOPY (5.57 Å) | Cite: | High-Resolution Cryo-Electron Microscopy Structure of the Trypanosoma Brucei Ribosome. Nature, 494, 2013
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4V8P
| T.thermophila 60S ribosomal subunit in complex with initiation factor 6. | Descriptor: | 26S RRNA, 5.8S RRNA, 5S RRNA, ... | Authors: | Klinge, S, Voigts-Hoffmann, F, Leibundgut, M, Arpagaus, S, Ban, N. | Deposit date: | 2011-09-14 | Release date: | 2014-07-09 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.52 Å) | Cite: | Crystal Structure of the Eukaryotic 60S Ribosomal Subunit in Complex with Initiation Factor 6. Science, 334, 2011
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5T2A
| CryoEM structure of the Leishmania donovani 80S ribosome at 2.9 Angstrom resolution | Descriptor: | 18S rRNA, 5.8S rRNA, 5S rRNA, ... | Authors: | Zhang, X, Lai, M, Zhou, Z.H. | Deposit date: | 2016-08-23 | Release date: | 2017-01-25 | Last modified: | 2018-07-18 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structures and stabilization of kinetoplastid-specific split rRNAs revealed by comparing leishmanial and human ribosomes. Nat Commun, 7, 2016
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5T2C
| CryoEM structure of the human ribosome at 3.6 Angstrom resolution | Descriptor: | 18S rRNA, 28S rRNA, 40S ribosomal protein S10, ... | Authors: | Zhang, X, Lai, M, Zhou, Z.H. | Deposit date: | 2016-08-23 | Release date: | 2017-01-25 | Last modified: | 2023-08-16 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structures and stabilization of kinetoplastid-specific split rRNAs revealed by comparing leishmanial and human ribosomes. Nat Commun, 7, 2016
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8RXH
| CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME WITH A/P/E-site tRNA AND mRNA : PARENTAL STRAIN | Descriptor: | (2S)-2-[2-[4-[[(2R,3S,4S)-3-acetyloxy-4-oxidanyl-pyrrolidin-2-yl]methyl]phenoxy]ethanoylamino]-6-azanyl-hexanoic acid, 40S ribosomal protein S12, 40S ribosomal protein S14, ... | Authors: | Rajan, K.S, Yonath, A. | Deposit date: | 2024-02-07 | Release date: | 2024-05-15 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (2.93 Å) | Cite: | Structural and mechanistic insights into the function of Leishmania ribosome lacking a single pseudouridine modification. Cell Rep, 43, 2024
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8RXX
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5T5H
| Structure and assembly model for the Trypanosoma cruzi 60S ribosomal subunit | Descriptor: | 40S ribosomal protein L14, 5.8S rRNA, 5S rRNA, ... | Authors: | Liu, Z, Gutierrez-Vargas, C, Wei, J, Grassucci, R.A, Ramesh, M, Espina, N, Sun, M, Tutuncuoglu, B, Madison-Antenucci, S, Woolford Jr, J.L, Tong, L, Frank, J. | Deposit date: | 2016-08-31 | Release date: | 2016-10-12 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (2.54 Å) | Cite: | Structure and assembly model for the Trypanosoma cruzi 60S ribosomal subunit. Proc.Natl.Acad.Sci.USA, 113, 2016
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8V84
| 60S ribosome biogenesis intermediate (Dbp10 catalytic structure - Overall map) | Descriptor: | 25S rRNA (cytosine(2870)-C(5))-methyltransferase, 60S ribosomal protein L13-A, 60S ribosomal protein L14-A, ... | Authors: | Cruz, V.E, Weirich, C.S, Peddada, N, Erzberger, J.P. | Deposit date: | 2023-12-04 | Release date: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | The DEAD-box ATPase Dbp10/DDX54 initiates peptidyl transferase center formation during 60S ribosome biogenesis. Nat Commun, 15, 2024
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8V83
| 60S ribosome biogenesis intermediate (Dbp10 pre-catalytic structure - Overall map) | Descriptor: | 25S rRNA (cytosine(2870)-C(5))-methyltransferase, 60S ribosomal protein L13-A, 60S ribosomal protein L14-A, ... | Authors: | Cruz, V.E, Weirich, C.S, Peddada, N, Erzberger, J.P. | Deposit date: | 2023-12-04 | Release date: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (2.53 Å) | Cite: | The DEAD-box ATPase Dbp10/DDX54 initiates peptidyl transferase center formation during 60S ribosome biogenesis. Nat Commun, 15, 2024
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5UMD
| Structure of the Plasmodium falciparum 80S ribosome bound to the antimalarial drug mefloquine | Descriptor: | 28S ribosomal RNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ... | Authors: | Wong, W, Bai, X.-C, Brown, A, Scheres, S, Baum, J. | Deposit date: | 2017-01-27 | Release date: | 2017-03-01 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Mefloquine targets the Plasmodium falciparum 80S ribosome to inhibit protein synthesis. Nat Microbiol, 2, 2017
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8B5L
| Cryo-EM structure of ribosome-Sec61-TRAP (TRanslocon Associated Protein) translocon complex | Descriptor: | 28S rRNA, 5.8S rRNA, 5S rRNA, ... | Authors: | Pauwels, E, Shewakramani, N.R, De Wijngaert, B, Vermeire, K, Das, K. | Deposit date: | 2022-09-23 | Release date: | 2023-03-01 | Last modified: | 2023-03-15 | Method: | ELECTRON MICROSCOPY (2.86 Å) | Cite: | Structural insights into TRAP association with ribosome-Sec61 complex and translocon inhibition by a CADA derivative. Sci Adv, 9, 2023
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8B6C
| Cryo-EM structure of ribosome-Sec61 in complex with cyclotriazadisulfonamide derivative CK147 | Descriptor: | 28S rRNA, 4-[[9-(cyclohexylmethyl)-3-methylidene-5-(4-methylphenyl)sulfonyl-1,5,9-triazacyclododec-1-yl]sulfonyl]-~{N},~{N}-dimethyl-aniline, 5.8S rRNA, ... | Authors: | Pauwels, E, Shewakramani, N.R, De Wijngaert, B, Vermeire, K, Das, K. | Deposit date: | 2022-09-26 | Release date: | 2023-02-22 | Last modified: | 2023-03-15 | Method: | ELECTRON MICROSCOPY (2.79 Å) | Cite: | Structural insights into TRAP association with ribosome-Sec61 complex and translocon inhibition by a CADA derivative. Sci Adv, 9, 2023
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6QZP
| High-resolution cryo-EM structure of the human 80S ribosome | Descriptor: | (3beta)-O~3~-[(2R)-2,6-dihydroxy-2-(2-methoxy-2-oxoethyl)-6-methylheptanoyl]cephalotaxine, 18S rRNA (1740-MER), 28S rRNA (3773-MER), ... | Authors: | Natchiar, S.K, Myasnikov, A.G, Kratzat, H, Hazemann, I, Klaholz, B.P. | Deposit date: | 2019-03-12 | Release date: | 2019-04-24 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Visualization of chemical modifications in the human 80S ribosome structure. Nature, 551, 2017
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8BTK
| Structure of the TRAP complex with the Sec translocon and a translating ribosome | Descriptor: | 18S rRNA, 28S rRNA, 40S ribosomal protein S11, ... | Authors: | Jaskolowski, M, Jomaa, A, Gamerdinger, M, Shrestha, S, Leibundgut, M, Deuerling, E, Ban, N. | Deposit date: | 2022-11-29 | Release date: | 2023-05-24 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Molecular basis of the TRAP complex function in ER protein biogenesis. Nat.Struct.Mol.Biol., 30, 2023
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8BPO
| Structure of rabbit 80S ribosome translating beta-tubulin in complex with tetratricopeptide protein 5 (TTC5) and S-phase Cyclin A Associated Protein residing in the ER (SCAPER) | Descriptor: | 28S ribosomal RNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ... | Authors: | Hopfler, M, Absmeier, E, Passmore, L.A, Hegde, R.S. | Deposit date: | 2022-11-17 | Release date: | 2023-07-05 | Last modified: | 2023-07-19 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Mechanism of ribosome-associated mRNA degradation during tubulin autoregulation. Mol.Cell, 83, 2023
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6R6P
| Structure of XBP1u-paused ribosome nascent chain complex (rotated state) | Descriptor: | 18S rRNA, 28S ribosomal RNA, 40S ribosomal protein S12, ... | Authors: | Shanmuganathan, V, Cheng, J, Berninghausen, O, Beckmann, R. | Deposit date: | 2019-03-27 | Release date: | 2019-07-10 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural and mutational analysis of the ribosome-arresting human XBP1u. Elife, 8, 2019
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6R6G
| Structure of XBP1u-paused ribosome nascent chain complex with SRP. | Descriptor: | 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S12, ... | Authors: | Shanmuganathan, V, Cheng, J, Braunger, K, Berninghausen, O, Beatrix, B, Beckmann, R. | Deposit date: | 2019-03-27 | Release date: | 2019-07-10 | Last modified: | 2019-10-30 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Structural and mutational analysis of the ribosome-arresting human XBP1u. Elife, 8, 2019
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8BHF
| Cryo-EM structure of stalled rabbit 80S ribosomes in complex with human CCR4-NOT and CNOT4 | Descriptor: | 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S11, ... | Authors: | Absmeier, E, Chandrasekaran, V, O'Reilly, F.J, Stowell, J.A.W, Rappsilber, J, Passmore, L.A. | Deposit date: | 2022-10-31 | Release date: | 2023-09-06 | Last modified: | 2023-11-01 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Modulation of GluA2-gamma 5 synaptic complex desensitization, polyamine block and antiepileptic perampanel inhibition by auxiliary subunit cornichon-2. Nat.Struct.Mol.Biol., 30, 2023
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6R7Q
| Structure of XBP1u-paused ribosome nascent chain complex with Sec61. | Descriptor: | 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S12, ... | Authors: | Shanmuganathan, V, Cheng, J, Braunger, K, Berninghausen, O, Beatrix, B, Beckmann, R. | Deposit date: | 2019-03-29 | Release date: | 2019-07-10 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Structural and mutational analysis of the ribosome-arresting human XBP1u. Elife, 8, 2019
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6R5Q
| Structure of XBP1u-paused ribosome nascent chain complex (post-state) | Descriptor: | 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S12, ... | Authors: | Shanmuganathan, V, Cheng, J, Berninghausen, O, Beckmann, R. | Deposit date: | 2019-03-25 | Release date: | 2019-07-10 | Last modified: | 2019-10-30 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structural and mutational analysis of the ribosome-arresting human XBP1u. Elife, 8, 2019
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7TOR
| Mammalian 80S ribosome bound with the ALS/FTD-associated dipeptide repeat protein GR20 | Descriptor: | 18S rRNA, 28S rRNA, 40S ribosomal protein S10, ... | Authors: | Loveland, A.B, Svidritskiy, E, Susorov, D, Lee, S, Park, A, Zvornicanin, S, Demo, G, Gao, F.B, Korostelev, A.A. | Deposit date: | 2022-01-24 | Release date: | 2022-05-25 | Last modified: | 2022-06-01 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Ribosome inhibition by C9ORF72-ALS/FTD-associated poly-PR and poly-GR proteins revealed by cryo-EM. Nat Commun, 13, 2022
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7TOQ
| Mammalian 80S ribosome bound with the ALS/FTD-associated dipeptide repeat protein poly-PR | Descriptor: | 18S rRNA, 28S rRNA, 40S ribosomal protein S10, ... | Authors: | Loveland, A.B, Svidritskiy, E, Susorov, D, Lee, S, Park, A, Zvornicanin, S, Demo, G, Gao, F.B, Korostelev, A.A. | Deposit date: | 2022-01-24 | Release date: | 2022-05-25 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Ribosome inhibition by C9ORF72-ALS/FTD-associated poly-PR and poly-GR proteins revealed by cryo-EM. Nat Commun, 13, 2022
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7TM3
| Structure of the rabbit 80S ribosome stalled on a 2-TMD Rhodopsin intermediate in complex with the multipass translocon | Descriptor: | 28S ribosomal RNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ... | Authors: | Kim, M.K, Lewis, A.J.O, Keenan, R.J, Hegde, R.S. | Deposit date: | 2022-01-19 | Release date: | 2022-10-19 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.25 Å) | Cite: | Mechanism of an intramembrane chaperone for multipass membrane proteins. Nature, 611, 2022
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7TUT
| Structure of the rabbit 80S ribosome stalled on a 4-TMD Rhodopsin intermediate in complex with the multipass translocon | Descriptor: | 28S ribosomal RNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ... | Authors: | Kim, M.K, Lewis, A.J.O, Keenan, R.J, Hegde, R.S. | Deposit date: | 2022-02-03 | Release date: | 2022-10-19 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.88 Å) | Cite: | Mechanism of an intramembrane chaperone for multipass membrane proteins. Nature, 611, 2022
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