8B6C

Cryo-EM structure of ribosome-Sec61 in complex with cyclotriazadisulfonamide derivative CK147

This is a non-PDB format compatible entry.

Summary for 8B6C

• Entry DOI: 10.2210/pdb8b6c/pdb
• Related: 8B5L
• EMDB information: 15863
• Descriptor: 60S ribosomal protein L21, 60S ribosomal protein L7a, 60S ribosomal protein L11, ... (50 entities in total)
• Functional Keywords: ribosome, sec61, trap, translocon, translation, rna binding protein, eef2, ck147, cada, translocon inhibitor, 80s, 60s, 40s, cyclotriazadisulfonamide, membrane protein
• Biological source: Oryctolagus cuniculus (rabbit); More
• Total number of polymer chains: 47
• Total formula weight: 2505605.89

Authors

Pauwels, E.,Shewakramani, N.R.,De Wijngaert, B.,Vermeire, K.,Das, K. (deposition date: 2022-09-26, release date: 2023-02-22, Last modification date: 2023-03-15)

• Primary citation: Pauwels, E.,Shewakramani, N.R.,De Wijngaert, B.,Camps, A.,Provinciael, B.,Stroobants, J.,Kalies, K.U.,Hartmann, E.,Maes, P.,Vermeire, K.,Das, K.; Structural insights into TRAP association with ribosome-Sec61 complex and translocon inhibition by a CADA derivative.; Sci Adv, 9:eadf0797-eadf0797, 2023; PubMed: 36867692; DOI: 10.1126/sciadv.adf0797

Experimental method

ELECTRON MICROSCOPY (2.79 Å)