8B6C
Cryo-EM structure of ribosome-Sec61 in complex with cyclotriazadisulfonamide derivative CK147
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (T) | 60S ribosomal protein L21 | polymer | 159 | 18478.8 | 1 | UniProt (G1SHQ2) Pfam (PF01157) | Oryctolagus cuniculus (rabbit) | |
| 2 | B (5) | 28S rRNA | polymer | 4808 | 1557700.9 | 1 | Oryctolagus cuniculus | ||
| 3 | C (F) | 60S ribosomal protein L7 | polymer | 225 | 26658.8 | 1 | UniProt (G1SV32) Pfam (PF08079) Pfam (PF00327) | Oryctolagus cuniculus (rabbit) | |
| 4 | D (D) | Ribosomal_L18_c domain-containing protein | polymer | 293 | 34077.4 | 1 | UniProt (G1SYJ6) UniProt (by SIFTS) (P19949) | Oryctolagus cuniculus (rabbit) | |
| 5 | E (S) | 60S ribosomal protein L18a | polymer | 176 | 20827.6 | 1 | Pfam (PF01775) UniProt (by SIFTS) (G1TTY7) | Oryctolagus cuniculus (rabbit) | |
| 6 | F (b) | 60S ribosomal protein L29 | polymer | 245 | 26708.7 | 1 | UniProt (G1SGR6) Pfam (PF01779) | Oryctolagus cuniculus (rabbit) | |
| 7 | G (B) | Ribosomal protein L3 | polymer | 394 | 45119.8 | 1 | UniProt (G1TL06) Pfam (PF00297) | Oryctolagus cuniculus (rabbit) | |
| 8 | H (d) | 60S ribosomal protein L31 | polymer | 107 | 12635.7 | 1 | UniProt (G1SHG0) Pfam (PF01198) | Oryctolagus cuniculus (rabbit) | |
| 9 | I (8) | 5.8S rRNA | polymer | 156 | 50143.6 | 1 | GenBank (4CXE_3) | Oryctolagus cuniculus (rabbit) | |
| 10 | J (G) | 60S ribosomal protein L7a | polymer | 319 | 36221.5 | 1 | UniProt (G1STW0) Pfam (PF01248) | Oryctolagus cuniculus (rabbit) | |
| 11 | K (J) | 60S ribosomal protein L11 | polymer | 170 | 19399.5 | 1 | UniProt (G1TUB8) Pfam (PF00281) Pfam (PF00673) | Oryctolagus cuniculus (rabbit) | |
| 12 | L (c) | 60S ribosomal protein L30 | polymer | 98 | 10914.8 | 1 | UniProt (G1TDL2) Pfam (PF01248) | Oryctolagus cuniculus (rabbit) | |
| 13 | M (j) | Ribosomal protein L37 | polymer | 86 | 10090.9 | 1 | UniProt (U3KPD5) Pfam (PF01907) | Oryctolagus cuniculus (rabbit) | |
| 14 | N (A) | Ribosomal protein L8 | polymer | 257 | 28088.9 | 1 | UniProt (G1TT27) Pfam (PF00181) Pfam (PF03947) | Oryctolagus cuniculus (rabbit) | |
| 15 | O (I) | Ribosomal protein L10 | polymer | 214 | 24643.1 | 1 | UniProt (B7NZQ2) Pfam (PF00252) | Oryctolagus cuniculus (rabbit) | |
| 16 | P (q) | Protein transport protein Sec61 subunit gamma | polymer | 68 | 7752.3 | 1 | UniProt (G1TPE6) Pfam (PF00584) | Oryctolagus cuniculus (Rabbit) | |
| 17 | Q (p) | 60S ribosomal protein L37a | polymer | 91 | 10168.2 | 1 | UniProt (G1SY53) Pfam (PF01780) | Oryctolagus cuniculus (rabbit) | |
| 18 | R (V) | 60S ribosomal protein L23 | polymer | 131 | 13972.4 | 1 | UniProt (G1T6D1) Pfam (PF00238) | Oryctolagus cuniculus (rabbit) | |
| 19 | S (m) | 60S ribosomal protein L40 | polymer | 52 | 6212.6 | 1 | UniProt (by SIFTS) (P0DXC2) | Oryctolagus cuniculus (rabbit) | |
| 20 | T (l) | 60S ribosomal protein L39-like | polymer | 50 | 6324.6 | 1 | UniProt (G1TTN1) Pfam (PF00832) | Oryctolagus cuniculus (rabbit) | |
| 21 | U (P) | 60S ribosomal protein L17 | polymer | 153 | 17758.7 | 1 | UniProt (G1SCJ6) Pfam (PF00237) | Oryctolagus cuniculus (rabbit) | |
| 22 | V (E) | 60S ribosomal protein L6 | polymer | 291 | 33028.3 | 1 | UniProt (G1SKF7) Pfam (PF03868) Pfam (PF01159) | Oryctolagus cuniculus (rabbit) | |
| 23 | W (Q) | eL18 | polymer | 188 | 21699.7 | 1 | UniProt (F6QKI9) Pfam (PF17135) UniProt (by SIFTS) (G1TFE0) | Oryctolagus cuniculus (rabbit) | |
| 24 | X (R) | 60S ribosomal protein L19 | polymer | 196 | 23535.3 | 1 | Pfam (PF01280) UniProt (by SIFTS) (G1TYL6) | Oryctolagus cuniculus (rabbit) | |
| 25 | Y (W) | Ribosomal protein L24 | polymer | 157 | 17825.1 | 1 | UniProt (G1SE28) Pfam (PF01246) | Oryctolagus cuniculus (rabbit) | |
| 26 | Z (O) | 60S ribosomal protein L13a | polymer | 203 | 23533.3 | 1 | UniProt (by SIFTS) (G1TVS8) | Oryctolagus cuniculus (rabbit) | |
| 27 | AA (K) | Protein transport protein Sec61 subunit alpha isoform 1 | polymer | 476 | 52279.4 | 1 | Pfam (PF10559) Pfam (PF00344) UniProt (by SIFTS) (A0A5F9CHB7) | Oryctolagus cuniculus (rabbit) | |
| 28 | BA (C) | 60S ribosomal protein L4 | polymer | 362 | 41114.4 | 1 | UniProt (A0A5F9DCT1) Pfam (PF00573) Pfam (PF14374) UniProt (by SIFTS) (G1SVW5) | Oryctolagus cuniculus (rabbit) | |
| 29 | CA (o) | 60S ribosomal protein L36a-like | polymer | 103 | 12070.5 | 1 | UniProt (G1U344) Pfam (PF00935) UniProt (by SIFTS) (G1T040) | Oryctolagus cuniculus (rabbit) | |
| 30 | DA (r) | 60S ribosomal protein L28 | polymer | 124 | 14220.7 | 1 | UniProt (G1U7L1) Pfam (PF01778) | Oryctolagus cuniculus (rabbit) | |
| 31 | EA (f) | 60S ribosomal protein L35a | polymer | 109 | 12449.6 | 1 | UniProt (G1SF08) Pfam (PF01247) | Oryctolagus cuniculus (rabbit) | |
| 32 | FA (e) | Ribosomal protein L32 | polymer | 128 | 15022.0 | 1 | UniProt (G1U437) Pfam (PF01655) UniProt (by SIFTS) (G1TUN8) | Oryctolagus cuniculus (rabbit) | |
| 33 | GA (Z) | 60S ribosomal protein L27 | polymer | 135 | 15704.6 | 1 | UniProt (G1TXF6) Pfam (PF00467) Pfam (PF01777) | Oryctolagus cuniculus (rabbit) | |
| 34 | HA (a) | 60S ribosomal protein L27a | polymer | 147 | 16489.4 | 1 | UniProt (G1SNY0) Pfam (PF00828) | Oryctolagus cuniculus (rabbit) | |
| 35 | IA (g) | 60S ribosomal protein L34 | polymer | 114 | 12994.6 | 1 | UniProt (G1TXG5) Pfam (PF01199) | Oryctolagus cuniculus (rabbit) | |
| 36 | JA (k) | 60S ribosomal protein L38 | polymer | 70 | 8238.9 | 1 | UniProt (G1U001) Pfam (PF01781) | Oryctolagus cuniculus (rabbit) | |
| 37 | KA (H) | 60S ribosomal protein L9 | polymer | 190 | 21627.2 | 1 | UniProt (G1SWI6) Pfam (PF00347) | Oryctolagus cuniculus (rabbit) | |
| 38 | LA (L) | 60S ribosomal protein L13 | polymer | 211 | 24331.7 | 1 | UniProt (G1TKB3) Pfam (PF01294) | Oryctolagus cuniculus (rabbit) | |
| 39 | MA (7) | 5S rRNA | polymer | 120 | 38691.9 | 1 | GenBank (4CXE_4) | Oryctolagus cuniculus (rabbit) | |
| 40 | NA (N) | Ribosomal protein L15 | polymer | 203 | 24076.1 | 1 | UniProt (G1T0C1) Pfam (PF00827) | Oryctolagus cuniculus (rabbit) | |
| 41 | OA (i) | 60S ribosomal protein L36 | polymer | 105 | 12263.8 | 1 | UniProt (G1TTQ5) Pfam (PF01158) | Oryctolagus cuniculus (rabbit) | |
| 42 | PA (h) | 60S ribosomal protein L35 | polymer | 122 | 14435.4 | 1 | UniProt (G1SIT5) Pfam (PF00831) | Oryctolagus cuniculus (rabbit) | |
| 43 | QA (M) | 60S ribosomal protein L14 | polymer | 138 | 16217.4 | 1 | UniProt (G1SZ12) Pfam (PF01929) | Oryctolagus cuniculus (rabbit) | |
| 44 | RA (Y) | Ribosomal protein L26 | polymer | 134 | 15891.8 | 1 | UniProt (G1SQH0) Pfam (PF16906) Pfam (PF00467) | Oryctolagus cuniculus (rabbit) | |
| 45 | SA (X) | Ribosomal_L23eN domain-containing protein | polymer | 118 | 13727.2 | 1 | UniProt (G1SE76) Pfam (PF03939) Pfam (PF00276) | Oryctolagus cuniculus (rabbit) | |
| 46 | TA (U) | 60S ribosomal protein L22 (Fragment) | polymer | 99 | 11495.3 | 1 | Pfam (PF01776) UniProt (by SIFTS) (G1TSG1) | Oryctolagus cuniculus (rabbit) | |
| 47 | UA (n) | 60S ribosomal protein L41 | polymer | 25 | 3473.5 | 1 | UniProt (A0A087WNH4) Pfam (PF05162) | Oryctolagus cuniculus (rabbit) | |
| 48 | AB, AC, AD, AE, AF... (5, 8, A, I, V...) | MAGNESIUM ION | non-polymer | 24.3 | 178 | Chemie (MG) | |||
| 49 | FH, IH, KH, NH, PH (j, p, m, o, g) | ZINC ION | non-polymer | 65.4 | 5 | Chemie (ZN) | |||
| 50 | MH (K) | 4-[[9-(cyclohexylmethyl)-3-methylidene-5-(4-methylphenyl)sulfonyl-1,5,9-triazacyclododec-1-yl]sulfonyl]-~{N},~{N}-dimethyl-aniline | non-polymer | 616.9 | 1 | Chemie (OWI) |
Sequence modifications
G: 1 - 319 (UniProt: G1STW0)
Q: 1 - 188 (UniProt: F6QKI9)
k: 1 - 70 (UniProt: G1U001)
L: 1 - 211 (UniProt: G1TKB3)
| PDB | External Database | Details |
|---|---|---|
| Gly 244 | Cys 244 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Arg 134 | Cys 134 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Lys 24 | Asn 24 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Arg 74 | His 74 | conflict |
| Arg 190 | His 190 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 47 |
| Total formula weight | 2500335.7 | |
| Non-Polymers* | Number of molecules | 184 |
| Total formula weight | 5270.2 | |
| All* | Total formula weight | 2505605.9 |
