8B6C
Cryo-EM structure of ribosome-Sec61 in complex with cyclotriazadisulfonamide derivative CK147
This is a non-PDB format compatible entry.
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | T | 60S ribosomal protein L21 | polymer | 159 | 18478.8 | 1 | UniProt (G1SHQ2) Pfam (PF01157) In PDB | Oryctolagus cuniculus (rabbit) | |
2 | 5 | 28S rRNA | polymer | 4808 | 1557700.9 | 1 | Oryctolagus cuniculus | ||
3 | F | 60S ribosomal protein L7 | polymer | 225 | 26658.8 | 1 | UniProt (G1SV32) Pfam (PF08079) Pfam (PF00327) In PDB | Oryctolagus cuniculus (rabbit) | |
4 | D | Ribosomal_L18_c domain-containing protein | polymer | 293 | 34077.4 | 1 | UniProt (G1SYJ6) UniProt (by SIFTS) (P19949) In PDB | Oryctolagus cuniculus (rabbit) | |
5 | S | 60S ribosomal protein L18a | polymer | 176 | 20827.6 | 1 | Pfam (PF01775) UniProt (by SIFTS) (G1TTY7) In PDB | Oryctolagus cuniculus (rabbit) | |
6 | b | 60S ribosomal protein L29 | polymer | 245 | 26708.7 | 1 | UniProt (G1SGR6) Pfam (PF01779) In PDB | Oryctolagus cuniculus (rabbit) | |
7 | B | Ribosomal protein L3 | polymer | 394 | 45119.8 | 1 | UniProt (G1TL06) Pfam (PF00297) In PDB | Oryctolagus cuniculus (rabbit) | |
8 | d | 60S ribosomal protein L31 | polymer | 107 | 12635.7 | 1 | UniProt (G1SHG0) Pfam (PF01198) In PDB | Oryctolagus cuniculus (rabbit) | |
9 | 8 | 5.8S rRNA | polymer | 156 | 50143.6 | 1 | GenBank (4CXE_3) | Oryctolagus cuniculus (rabbit) | |
10 | G | 60S ribosomal protein L7a | polymer | 319 | 36221.5 | 1 | UniProt (G1STW0) Pfam (PF01248) In PDB | Oryctolagus cuniculus (rabbit) | |
11 | J | 60S ribosomal protein L11 | polymer | 170 | 19399.5 | 1 | UniProt (G1TUB8) Pfam (PF00281) Pfam (PF00673) In PDB | Oryctolagus cuniculus (rabbit) | |
12 | c | 60S ribosomal protein L30 | polymer | 98 | 10914.8 | 1 | UniProt (G1TDL2) Pfam (PF01248) In PDB | Oryctolagus cuniculus (rabbit) | |
13 | j | Ribosomal protein L37 | polymer | 86 | 10090.9 | 1 | UniProt (U3KPD5) Pfam (PF01907) In PDB | Oryctolagus cuniculus (rabbit) | |
14 | A | Ribosomal protein L8 | polymer | 257 | 28088.9 | 1 | UniProt (G1TT27) Pfam (PF00181) Pfam (PF03947) In PDB | Oryctolagus cuniculus (rabbit) | |
15 | I | Ribosomal protein L10 | polymer | 214 | 24643.1 | 1 | UniProt (B7NZQ2) Pfam (PF00252) In PDB | Oryctolagus cuniculus (rabbit) | |
16 | q | Protein transport protein Sec61 subunit gamma | polymer | 68 | 7752.3 | 1 | UniProt (G1TPE6) Pfam (PF00584) In PDB | Oryctolagus cuniculus (Rabbit) | |
17 | p | 60S ribosomal protein L37a | polymer | 91 | 10168.2 | 1 | UniProt (G1SY53) Pfam (PF01780) In PDB | Oryctolagus cuniculus (rabbit) | |
18 | V | 60S ribosomal protein L23 | polymer | 131 | 13972.4 | 1 | UniProt (G1T6D1) Pfam (PF00238) In PDB | Oryctolagus cuniculus (rabbit) | |
19 | m | 60S ribosomal protein L40 | polymer | 52 | 6212.6 | 1 | UniProt (by SIFTS) (P0DXC2) In PDB | Oryctolagus cuniculus (rabbit) | |
20 | l | 60S ribosomal protein L39-like | polymer | 50 | 6324.6 | 1 | UniProt (G1TTN1) Pfam (PF00832) In PDB | Oryctolagus cuniculus (rabbit) | |
21 | P | 60S ribosomal protein L17 | polymer | 153 | 17758.7 | 1 | UniProt (G1SCJ6) Pfam (PF00237) In PDB | Oryctolagus cuniculus (rabbit) | |
22 | E | 60S ribosomal protein L6 | polymer | 291 | 33028.3 | 1 | UniProt (G1SKF7) Pfam (PF03868) Pfam (PF01159) In PDB | Oryctolagus cuniculus (rabbit) | |
23 | Q | eL18 | polymer | 188 | 21699.7 | 1 | UniProt (F6QKI9) Pfam (PF17135) UniProt (by SIFTS) (G1TFE0) In PDB | Oryctolagus cuniculus (rabbit) | |
24 | R | 60S ribosomal protein L19 | polymer | 196 | 23535.3 | 1 | Pfam (PF01280) UniProt (by SIFTS) (G1TYL6) In PDB | Oryctolagus cuniculus (rabbit) | |
25 | W | Ribosomal protein L24 | polymer | 157 | 17825.1 | 1 | UniProt (G1SE28) Pfam (PF01246) In PDB | Oryctolagus cuniculus (rabbit) | |
26 | O | 60S ribosomal protein L13a | polymer | 203 | 23533.3 | 1 | UniProt (by SIFTS) (G1TVS8) In PDB | Oryctolagus cuniculus (rabbit) | |
27 | K | Protein transport protein Sec61 subunit alpha isoform 1 | polymer | 476 | 52279.4 | 1 | Pfam (PF10559) Pfam (PF00344) UniProt (by SIFTS) (A0A5F9CHB7) In PDB | Oryctolagus cuniculus (rabbit) | |
28 | C | 60S ribosomal protein L4 | polymer | 362 | 41114.4 | 1 | UniProt (A0A5F9DCT1) Pfam (PF00573) Pfam (PF14374) UniProt (by SIFTS) (G1SVW5) In PDB | Oryctolagus cuniculus (rabbit) | |
29 | o | 60S ribosomal protein L36a-like | polymer | 103 | 12070.5 | 1 | UniProt (G1U344) Pfam (PF00935) UniProt (by SIFTS) (G1T040) In PDB | Oryctolagus cuniculus (rabbit) | |
30 | r | 60S ribosomal protein L28 | polymer | 124 | 14220.7 | 1 | UniProt (G1U7L1) Pfam (PF01778) In PDB | Oryctolagus cuniculus (rabbit) | |
31 | f | 60S ribosomal protein L35a | polymer | 109 | 12449.6 | 1 | UniProt (G1SF08) Pfam (PF01247) In PDB | Oryctolagus cuniculus (rabbit) | |
32 | e | Ribosomal protein L32 | polymer | 128 | 15022.0 | 1 | UniProt (G1U437) Pfam (PF01655) UniProt (by SIFTS) (G1TUN8) In PDB | Oryctolagus cuniculus (rabbit) | |
33 | Z | 60S ribosomal protein L27 | polymer | 135 | 15704.6 | 1 | UniProt (G1TXF6) Pfam (PF00467) Pfam (PF01777) In PDB | Oryctolagus cuniculus (rabbit) | |
34 | a | 60S ribosomal protein L27a | polymer | 147 | 16489.4 | 1 | UniProt (G1SNY0) Pfam (PF00828) In PDB | Oryctolagus cuniculus (rabbit) | |
35 | g | 60S ribosomal protein L34 | polymer | 114 | 12994.6 | 1 | UniProt (G1TXG5) Pfam (PF01199) In PDB | Oryctolagus cuniculus (rabbit) | |
36 | k | 60S ribosomal protein L38 | polymer | 70 | 8238.9 | 1 | UniProt (G1U001) Pfam (PF01781) In PDB | Oryctolagus cuniculus (rabbit) | |
37 | H | 60S ribosomal protein L9 | polymer | 190 | 21627.2 | 1 | UniProt (G1SWI6) Pfam (PF00347) In PDB | Oryctolagus cuniculus (rabbit) | |
38 | L | 60S ribosomal protein L13 | polymer | 211 | 24331.7 | 1 | UniProt (G1TKB3) Pfam (PF01294) In PDB | Oryctolagus cuniculus (rabbit) | |
39 | 7 | 5S rRNA | polymer | 120 | 38691.9 | 1 | GenBank (4CXE_4) | Oryctolagus cuniculus (rabbit) | |
40 | N | Ribosomal protein L15 | polymer | 203 | 24076.1 | 1 | UniProt (G1T0C1) Pfam (PF00827) In PDB | Oryctolagus cuniculus (rabbit) | |
41 | i | 60S ribosomal protein L36 | polymer | 105 | 12263.8 | 1 | UniProt (G1TTQ5) Pfam (PF01158) In PDB | Oryctolagus cuniculus (rabbit) | |
42 | h | 60S ribosomal protein L35 | polymer | 122 | 14435.4 | 1 | UniProt (G1SIT5) Pfam (PF00831) In PDB | Oryctolagus cuniculus (rabbit) | |
43 | M | 60S ribosomal protein L14 | polymer | 138 | 16217.4 | 1 | UniProt (G1SZ12) Pfam (PF01929) In PDB | Oryctolagus cuniculus (rabbit) | |
44 | Y | Ribosomal protein L26 | polymer | 134 | 15891.8 | 1 | UniProt (G1SQH0) Pfam (PF16906) Pfam (PF00467) In PDB | Oryctolagus cuniculus (rabbit) | |
45 | X | Ribosomal_L23eN domain-containing protein | polymer | 118 | 13727.2 | 1 | UniProt (G1SE76) Pfam (PF03939) Pfam (PF00276) In PDB | Oryctolagus cuniculus (rabbit) | |
46 | U | 60S ribosomal protein L22 (Fragment) | polymer | 99 | 11495.3 | 1 | Pfam (PF01776) UniProt (by SIFTS) (G1TSG1) In PDB | Oryctolagus cuniculus (rabbit) | |
47 | n | 60S ribosomal protein L41 | polymer | 25 | 3473.5 | 1 | UniProt (A0A087WNH4) Pfam (PF05162) In PDB | Oryctolagus cuniculus (rabbit) | |
48 | 5, 8, A, I, V... | MAGNESIUM ION | non-polymer | 24.3 | 178 | Chemie (MG) | |||
49 | j, p, m, o, g | ZINC ION | non-polymer | 65.4 | 5 | Chemie (ZN) | |||
50 | K | 4-[[9-(cyclohexylmethyl)-3-methylidene-5-(4-methylphenyl)sulfonyl-1,5,9-triazacyclododec-1-yl]sulfonyl]-~{N},~{N}-dimethyl-aniline | non-polymer | 616.9 | 1 | Chemie (OWI) |
Sequence modifications
G: 1 - 319 (UniProt: G1STW0)
Q: 1 - 188 (UniProt: F6QKI9)
k: 1 - 70 (UniProt: G1U001)
L: 1 - 211 (UniProt: G1TKB3)
PDB | External Database | Details |
---|---|---|
Gly 244 | Cys 244 | conflict |
PDB | External Database | Details |
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Arg 134 | Cys 134 | conflict |
PDB | External Database | Details |
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Lys 24 | Asn 24 | conflict |
PDB | External Database | Details |
---|---|---|
Arg 74 | His 74 | conflict |
Arg 190 | His 190 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 47 |
Total formula weight | 2500335.7 | |
Non-Polymers* | Number of molecules | 184 |
Total formula weight | 5270.2 | |
All* | Total formula weight | 2505605.9 |