6ZN5
| SARS-CoV-2 Nsp1 bound to a pre-40S-like ribosome complex - state 2 | Descriptor: | 18S ribosomal RNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... | Authors: | Thoms, M, Buschauer, R, Ameismeier, M, Denk, T, Kratzat, H, Mackens-Kiani, T, Cheng, J, Berninghausen, O, Becker, T, Beckmann, R. | Deposit date: | 2020-07-06 | Release date: | 2020-07-29 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2. Science, 369, 2020
|
|
8XSZ
| Cryo-EM structure of the human 80S ribosome with Tigecycline, E-tRNA and P-tRNA | Descriptor: | 18S rRNA, 28S rRNA, 40S ribosomal protein S10, ... | Authors: | Li, X, Wang, M, Cheng, J. | Deposit date: | 2024-01-10 | Release date: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline. Nat Commun, 15, 2024
|
|
6Y0G
| Structure of human ribosome in classical-PRE state | Descriptor: | 18S ribosomal RNA, 28S ribosomal RNA, 4-{(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidine-2,6-dione, ... | Authors: | Bhaskar, V, Schenk, A.D, Cavadini, S, von Loeffelholz, O, Natchiar, S.K, Klaholz, B.P, Chao, J.A. | Deposit date: | 2020-02-07 | Release date: | 2020-04-15 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Dynamics of uS19 C-Terminal Tail during the Translation Elongation Cycle in Human Ribosomes. Cell Rep, 31, 2020
|
|
7TQL
| CryoEM structure of the human 40S small ribosomal subunit in complex with translation initiation factors eIF1A and eIF5B. | Descriptor: | 18S ribosomal RNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... | Authors: | Lapointe, C.P, Grosely, R, Sokabe, M, Alvarado, C, Wang, J, Montabana, E, Villa, N, Shin, B, Dever, T, Fraser, C, Fernandez, I.S, Puglisi, J.D. | Deposit date: | 2022-01-26 | Release date: | 2022-04-27 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | eIF5B and eIF1A reorient initiator tRNA to allow ribosomal subunit joining. Nature, 607, 2022
|
|
8PJ4
| Structure of human 48S translation initiation complex after eIF5 release (48S-4) | Descriptor: | 18S rRNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... | Authors: | Petrychenko, V, Yi, S.-H, Liedtke, D, Peng, B.Z, Rodnina, M.V, Fischer, N. | Deposit date: | 2023-06-22 | Release date: | 2024-08-14 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structural basis for translational control by the human 48S initiation complex from codon scanning toward subunit joining Nat.Struct.Mol.Biol., 2024
|
|
6KIU
| Cryo-EM structure of human MLL1-ubNCP complex (3.2 angstrom) | Descriptor: | DNA (145-MER), GLUTAMINE, Histone H2A, ... | Authors: | Huang, J, Xue, H, Yao, T. | Deposit date: | 2019-07-20 | Release date: | 2019-09-11 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structural basis of nucleosome recognition and modification by MLL methyltransferases. Nature, 573, 2019
|
|
8X7I
| Cryo-EM structures of RNF168/UbcH5c-Ub in complex with H2AK13Ub nucleosomes determined by intein-based E2-Ub-NCP conjugation strategy | Descriptor: | DNA (147-MER), E3 ubiquitin-protein ligase RNF168, Histone H2A type 1-B/E, ... | Authors: | Ai, H.S, Tong, Z.B, Deng, Z.H, Pan, M, Liu, L. | Deposit date: | 2023-11-24 | Release date: | 2024-08-07 | Method: | ELECTRON MICROSCOPY (3.27 Å) | Cite: | Capturing Snapshots of Nucleosomal H2A K13/K15 Ubiquitination Mediated by the Monomeric E3 Ligase RNF168 Biorxiv, 2024
|
|
7WU0
| Cryo-EM structure of a human pre-40S ribosomal subunit - State RRP12-B3 | Descriptor: | 18S rRNA, 40S ribosomal protein S11, 40S ribosomal protein S12, ... | Authors: | Cheng, J, Lau, B, Thoms, M, Ameismeier, M, Berninghausen, O, Hurt, E, Beckmann, R. | Deposit date: | 2022-02-05 | Release date: | 2022-10-19 | Last modified: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | The nucleoplasmic phase of pre-40S formation prior to nuclear export. Nucleic Acids Res., 50, 2022
|
|
7JQC
| SARS-CoV-2 Nsp1, CrPV IRES and rabbit 40S ribosome complex | Descriptor: | 40S ribosomal protein S21, 40S ribosomal protein S24, 40S ribosomal protein S26, ... | Authors: | Yuan, S, Xiong, Y. | Deposit date: | 2020-08-10 | Release date: | 2020-12-02 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Nonstructural Protein 1 of SARS-CoV-2 Is a Potent Pathogenicity Factor Redirecting Host Protein Synthesis Machinery toward Viral RNA. Mol.Cell, 80, 2020
|
|
8X7J
| Cryo-EM structures of RNF168/UbcH5c-Ub/nucleosomes complex determined by activity-based chemical trapping strategy | Descriptor: | DNA (144-MER), E3 ubiquitin-protein ligase RNF168, Histone H2A type 1-B/E, ... | Authors: | Ai, H.S, Tong, Z.B, Deng, Z.H, Pan, M, Liu, L. | Deposit date: | 2023-11-24 | Release date: | 2024-08-07 | Method: | ELECTRON MICROSCOPY (3.39 Å) | Cite: | Capturing Snapshots of Nucleosomal H2A K13/K15 Ubiquitination Mediated by the Monomeric E3 Ligase RNF168 Biorxiv, 2024
|
|
6OLG
| |
8PJ2
| Structure of human 48S translation initiation complex in AUG recognition state after eIF5-induced GTP hydrolysis by eIF2 (48S-2) | Descriptor: | 18S rRNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... | Authors: | Petrychenko, V, Yi, S.-H, Liedtke, D, Peng, B.Z, Rodnina, M.V, Fischer, N. | Deposit date: | 2023-06-22 | Release date: | 2024-08-14 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structural basis for translational control by the human 48S initiation complex from codon scanning toward subunit joining Nat.Struct.Mol.Biol., 2024
|
|
8PJ1
| Structure of human 48S translation initiation complex in open codon scanning state (48S-1) | Descriptor: | 18S rRNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... | Authors: | Petrychenko, V, Yi, S.-H, Liedtke, D, Peng, B.Z, Rodnina, M.V, Fischer, N. | Deposit date: | 2023-06-22 | Release date: | 2024-08-14 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structural basis for translational control by the human 48S initiation complex from codon scanning toward subunit joining Nat.Struct.Mol.Biol., 2024
|
|
6G5I
| Cryo-EM structure of a late human pre-40S ribosomal subunit - State R | Descriptor: | 18S ribosomal RNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... | Authors: | Ameismeier, M, Cheng, J, Berninghausen, O, Beckmann, R. | Deposit date: | 2018-03-29 | Release date: | 2018-06-06 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Visualizing late states of human 40S ribosomal subunit maturation. Nature, 558, 2018
|
|
8OZ0
| Structure of a human 48S translation initiation complex with eIF4F and eIF4A | Descriptor: | 18S rRNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... | Authors: | Brito Querido, J, Sokabe, M, Diaz-Lopez, I, Gordiyenko, Y, Fraser, C.S, Ramakrishnan, V. | Deposit date: | 2023-05-06 | Release date: | 2024-02-07 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | The structure of a human translation initiation complex reveals two independent roles for the helicase eIF4A. Nat.Struct.Mol.Biol., 31, 2024
|
|
6OLI
| |
6Y57
| Structure of human ribosome in hybrid-PRE state | Descriptor: | 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ... | Authors: | Bhaskar, V, Schenk, A.D, Cavadini, S, von Loeffelholz, O, Natchiar, S.K, Klaholz, B.P, Chao, J.A. | Deposit date: | 2020-02-25 | Release date: | 2020-04-15 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Dynamics of uS19 C-Terminal Tail during the Translation Elongation Cycle in Human Ribosomes. Cell Rep, 31, 2020
|
|
5AJ0
| Cryo electron microscopy of actively translating human polysomes (POST state). | Descriptor: | 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ... | Authors: | Behrmann, E, Loerke, J, Budkevich, T.V, Yamamoto, K, Schmidt, A, Penczek, P.A, Vos, M.R, Burger, J, Mielke, T, Scheerer, P, Spahn, C.M.T. | Deposit date: | 2015-02-19 | Release date: | 2015-05-20 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structural Snapshots of Actively Translating Human Ribosomes Cell(Cambridge,Mass.), 161, 2015
|
|
7A09
| Structure of a human ABCE1-bound 43S pre-initiation complex - State III | Descriptor: | 18S ribosomal RNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... | Authors: | Kratzat, H, Mackens-Kiani, T, Ameismeier, A, Cheng, J, Berninghausen, O, Becker, T, Beckmann, R. | Deposit date: | 2020-08-07 | Release date: | 2020-10-14 | Last modified: | 2021-01-13 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | A structural inventory of native ribosomal ABCE1-43S pre-initiation complexes. Embo J., 40, 2021
|
|
7WTV
| Cryo-EM structure of a human pre-40S ribosomal subunit - State RRP12-A2 | Descriptor: | 18S rRNA, 40S ribosomal protein S11, 40S ribosomal protein S12, ... | Authors: | Cheng, J, Lau, B, Thoms, M, Ameismeier, M, Berninghausen, O, Hurt, E, Beckmann, R. | Deposit date: | 2022-02-05 | Release date: | 2022-10-19 | Last modified: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | The nucleoplasmic phase of pre-40S formation prior to nuclear export. Nucleic Acids Res., 50, 2022
|
|
8XXN
| Cryo-EM structure of the human 43S ribosome with PDCD4 | Descriptor: | 18S rRNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... | Authors: | Ye, X, Huang, Z, Li, Y, Wang, M, Cheng, J. | Deposit date: | 2024-01-18 | Release date: | 2024-05-01 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Human tumor suppressor PDCD4 directly interacts with ribosomes to repress translation. Cell Res., 34, 2024
|
|
6G18
| Cryo-EM structure of a late human pre-40S ribosomal subunit - State C | Descriptor: | 40S ribosomal protein S11, 40S ribosomal protein S12, 40S ribosomal protein S13, ... | Authors: | Ameismeier, M, Cheng, J, Berninghausen, O, Beckmann, R. | Deposit date: | 2018-03-20 | Release date: | 2018-06-06 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Visualizing late states of human 40S ribosomal subunit maturation. Nature, 558, 2018
|
|
6G5H
| Cryo-EM structure of a late human pre-40S ribosomal subunit - Mature | Descriptor: | 18S ribosomal RNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... | Authors: | Ameismeier, M, Cheng, J, Berninghausen, O, Beckmann, R. | Deposit date: | 2018-03-29 | Release date: | 2018-06-06 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Visualizing late states of human 40S ribosomal subunit maturation. Nature, 558, 2018
|
|
5LKS
| Structure-function insights reveal the human ribosome as a cancer target for antibiotics | Descriptor: | 18S ribosomal RNA, 28S ribosomal RNA, 4-{(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidine-2,6-dione, ... | Authors: | Myasnikov, A.G, Natchiar, S.K, Nebout, M, Hazemann, I, Imbert, V, Khatter, H, Peyron, J.-F, Klaholz, B.P. | Deposit date: | 2016-07-23 | Release date: | 2017-04-26 | Last modified: | 2019-12-11 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structure-function insights reveal the human ribosome as a cancer target for antibiotics. Nat Commun, 7, 2016
|
|
4UG0
| STRUCTURE OF THE HUMAN 80S RIBOSOME | Descriptor: | 18S ribosomal RNA, 28S ribosomal RNA, 40S RIBOSOMAL PROTEIN, ... | Authors: | Khatter, H, Myasnikov, A.G, Natchiar, S.K, Klaholz, B.P. | Deposit date: | 2015-03-20 | Release date: | 2015-06-10 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structure of the human 80S ribosome NATURE, 520, 2015
|
|