8SG7
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3ZIP
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![BU of 3zip by Molmil](/molmil-images/mine/3zip) | minor-site specific NLS (A58) | Descriptor: | A58NLS, IMPORTIN SUBUNIT ALPHA-2 | Authors: | Chang, C.-W, Counago, R.M, Williams, S.J, Kobe, B. | Deposit date: | 2013-01-10 | Release date: | 2013-08-21 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Distinctive Conformation of Minor Site-Specific Nuclear Localization Signals Bound to Importin-Alpha Traffic, 14, 2013
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4U54
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![BU of 4u54 by Molmil](/molmil-images/mine/4u54) | IMPORTIN-ALPHA MINOR NLS SITE INHIBITOR | Descriptor: | Importin subunit alpha-1, N-methyl-1-[3-(pyridin-3-yl)phenyl]methanamine | Authors: | Stewart, M, Valkov, E, Holvey, R.S. | Deposit date: | 2014-07-24 | Release date: | 2015-05-13 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.41 Å) | Cite: | Selective Targeting of the TPX2 Site of Importin-alpha Using Fragment-Based Ligand Design. Chemmedchem, 10, 2015
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8TUU
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1IAL
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![BU of 1ial by Molmil](/molmil-images/mine/1ial) | IMPORTIN ALPHA, MOUSE | Descriptor: | IMPORTIN ALPHA | Authors: | Kobe, B. | Deposit date: | 1999-01-12 | Release date: | 1999-06-15 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Autoinhibition by an internal nuclear localization signal revealed by the crystal structure of mammalian importin alpha. Nat.Struct.Biol., 6, 1999
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1PJN
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![BU of 1pjn by Molmil](/molmil-images/mine/1pjn) | Mouse Importin alpha-bipartite NLS N1N2 from Xenopus laevis phosphoprotein Complex | Descriptor: | Histone-binding protein N1/N2, Importin alpha-2 subunit | Authors: | Fontes, M.R.M, Teh, T, Jans, D, Brinkworth, R.I, Kobe, B. | Deposit date: | 2003-06-03 | Release date: | 2003-08-19 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural basis for the specificity of bipartite nuclear localization sequence binding by importin-alpha J.Biol.Chem., 278, 2003
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1PJM
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![BU of 1pjm by Molmil](/molmil-images/mine/1pjm) | Mouse Importin alpha-bipartite NLS from human retinoblastoma protein Complex | Descriptor: | Importin alpha-2 subunit, Retinoblastoma-associated protein | Authors: | Fontes, M.R.M, Teh, T, Jans, D, Brinkworth, R.I, Kobe, B. | Deposit date: | 2003-06-03 | Release date: | 2003-08-19 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural basis for the specificity of bipartite nuclear localization sequence binding by importin-alpha J.Biol.Chem., 278, 2003
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6MJL
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![BU of 6mjl by Molmil](/molmil-images/mine/6mjl) | Crystal structure of ChREBP NLS peptide bound to importin alpha. | Descriptor: | ChREBP Peptide ASN-TYR-TRP-LYS-ARG-ARG-ILE-GLU-VAL, Importin subunit alpha-1 | Authors: | Jung, H, Uyeda, K. | Deposit date: | 2018-09-21 | Release date: | 2019-09-25 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | The structure of importin alpha and the nuclear localization peptide of ChREBP, and small compound inhibitors of ChREBP-importin alpha interactions. Biochem.J., 477, 2020
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6BVT
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![BU of 6bvt by Molmil](/molmil-images/mine/6bvt) | Importin alpha 1 in cargo free state | Descriptor: | Importin subunit alpha-1 | Authors: | Smith, K.M, Tsimablyuk, S, Edwards, M.R, Aragao, D, Cross, E.M, Basler, C.F, Forwood, J.K. | Deposit date: | 2017-12-13 | Release date: | 2018-07-04 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural basis for importin alpha 3 specificity of W proteins in Hendra and Nipah viruses. Nat Commun, 9, 2018
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1Q1T
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![BU of 1q1t by Molmil](/molmil-images/mine/1q1t) | Mouse Importin alpha: non-phosphorylated SV40 CN peptide complex | Descriptor: | Importin alpha-2 subunit, Large T antigen | Authors: | Fontes, M.R.M, Teh, T, Toth, G, John, A, Pavo, I, Jans, D.A, Kobe, B. | Deposit date: | 2003-07-22 | Release date: | 2004-03-30 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Role of flanking sequences and phosphorylation in the recognition of the simian-virus-40 large T-antigen nuclear localization sequences by importin-alpha Biochem.J., 375, 2003
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3Q5U
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4U5L
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![BU of 4u5l by Molmil](/molmil-images/mine/4u5l) | IMPORTIN-ALPHA MINOR NLS SITE INHIBITOR | Descriptor: | Importin subunit alpha-1, N~2~-[4-(pyridin-3-yl)benzyl]-L-lysinamide | Authors: | Stewart, M, Valkov, E, Holvey, R.S. | Deposit date: | 2014-07-25 | Release date: | 2015-05-13 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.53 Å) | Cite: | Selective Targeting of the TPX2 Site of Importin-alpha Using Fragment-Based Ligand Design. Chemmedchem, 10, 2015
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8TUT
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![BU of 8tut by Molmil](/molmil-images/mine/8tut) | Merkel Cell Polyomavirus LTA NLSct bound to importin alpha 2 | Descriptor: | Importin subunit alpha-1, PRO-PRO-LYS-PRO-LYS-LYS-ASN-ARG-GLU | Authors: | Cross, E.M, Forwood, J.K, Alvisi, G. | Deposit date: | 2023-08-17 | Release date: | 2024-02-07 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | A functional and structural comparative analysis of large tumor antigens reveals evolution of different importin alpha-dependent nuclear localization signals. Protein Sci., 33, 2024
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4U58
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![BU of 4u58 by Molmil](/molmil-images/mine/4u58) | IMPORTIN-ALPHA MINOR NLS SITE INHIBITOR | Descriptor: | Importin subunit alpha-1, N~2~-[4-(pyridin-3-yl)benzoyl]-L-lysinamide | Authors: | Stewart, M, Valkov, E, Holvey, R.S. | Deposit date: | 2014-07-24 | Release date: | 2015-05-13 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.56 Å) | Cite: | Selective Targeting of the TPX2 Site of Importin-alpha Using Fragment-Based Ligand Design. Chemmedchem, 10, 2015
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8U36
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8TUS
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![BU of 8tus by Molmil](/molmil-images/mine/8tus) | WU Polyomavirus LTA NLS bound to importin alpha 2 | Descriptor: | Importin subunit alpha-1, Large T antigen | Authors: | Donnelly, C.M, Cross, E.M, Forwood, J.K, Alvisi, G. | Deposit date: | 2023-08-17 | Release date: | 2024-02-07 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | A functional and structural comparative analysis of large tumor antigens reveals evolution of different importin alpha-dependent nuclear localization signals. Protein Sci., 33, 2024
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8FK3
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7RG4
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![BU of 7rg4 by Molmil](/molmil-images/mine/7rg4) | Importin alpha2 in complex with p50 NLS | Descriptor: | Importin subunit alpha-1, Isoform 3 of Nuclear factor NF-kappa-B p105 subunit | Authors: | Smith, K.M, Tsimbalyuk, S, Aragao, D, Forwood, J.K. | Deposit date: | 2021-07-14 | Release date: | 2021-08-25 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | MERS-CoV ORF4b employs an unusual binding mechanism to target IMP alpha and block innate immunity. Nat Commun, 13, 2022
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8G8Q
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8G8R
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3BTR
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![BU of 3btr by Molmil](/molmil-images/mine/3btr) | AR-NLS:Importin-alpha complex | Descriptor: | Androgen receptor, Importin subunit alpha-2 | Authors: | Cutress, M.L, Whitaker, H.C, Mills, I.G, Stewart, M, Neal, D.E. | Deposit date: | 2007-12-30 | Release date: | 2008-12-30 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural basis for the nuclear import of the human androgen receptor J.Cell.Sci., 121, 2008
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5KLT
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![BU of 5klt by Molmil](/molmil-images/mine/5klt) | Prototypical P4[M]cNLS | Descriptor: | Importin subunit alpha-1, Prototypical P4[M]cNLS | Authors: | Smith, K.M, Forwood, J.K. | Deposit date: | 2016-06-25 | Release date: | 2016-07-27 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Contribution of the residue at position 4 within classical nuclear localization signals to modulating interaction with importins and nuclear targeting. Biochim Biophys Acta Mol Cell Res, 1865, 2018
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3RZX
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6WBB
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![BU of 6wbb by Molmil](/molmil-images/mine/6wbb) | Structure of Mouse Importin alpha - MLH1-E475A NLS peptide complex | Descriptor: | DNA mismatch repair protein Mlh1, Importin subunit alpha-1 | Authors: | De Barros, A.C, Da Silva, T.D, Oliveira, H.C, Fukuda, C.A, Fontes, M.R.M. | Deposit date: | 2020-03-26 | Release date: | 2021-07-07 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.663 Å) | Cite: | Structural and calorimetric studies reveal specific determinants for the binding of a high-affinity NLS to mammalian importin-alpha. Biochem.J., 478, 2021
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8F2Q
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