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PDB: 413 results
7RBM
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BU of 7rbm by Molmil
Human DNA polymerase beta crosslinked complex, 60 s Ca to Mn exchange
Descriptor: 2-deoxy-3,5-di-O-phosphono-D-erythro-pentitol, DNA (5'-D(*CP*CP*GP*AP*CP*GP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*CP*C)-3'), ...
Authors:Kumar, A.
Deposit date:2021-07-06
Release date:2022-03-09
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Interlocking activities of DNA polymerase beta in the base excision repair pathway.
Proc.Natl.Acad.Sci.USA, 119, 2022
4PHD
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BU of 4phd by Molmil
Structure of human DNA polymerase beta complexed with A in the template base paired with incoming non-hydrolyzable CTP and MANGANESE
Descriptor: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine, DNA (5'-D(*CP*CP*GP*AP*CP*AP*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*A)-3'), ...
Authors:Koag, M.C, Lee, S.
Deposit date:2014-05-06
Release date:2014-09-24
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:The spontaneous replication error and the mismatch discrimination mechanisms of human DNA polymerase beta.
Nucleic Acids Res., 42, 2015
7S9O
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BU of 7s9o by Molmil
Binary complex of DNA Polymerase Beta with Ring open Intermediate Fapy-dG in the template position
Descriptor: DNA (5'-D(*CP*CP*GP*AP*C*(IFP)P*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*A*(SO4))-3'), DNA (5'-D(P*GP*TP*CP*GP*G)-3'), ...
Authors:Freudenthal, B.D, Ryan, B.J.
Deposit date:2021-09-21
Release date:2022-08-03
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.23 Å)
Cite:Structural Dynamics of a Common Mutagenic Oxidative DNA Lesion in Duplex DNA and during DNA Replication.
J.Am.Chem.Soc., 144, 2022
4YN4
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BU of 4yn4 by Molmil
Structure of human DNA polymerase beta complexed with N7BG in the template opposite to incoming non-hydrolyzable dTTP WITH MANGANESE IN THE ACTIVE SITE
Descriptor: 5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]thymidine, DNA 10-mer (up-primer), DNA 16-mer (template), ...
Authors:Lee, S, Koag, M.-C.
Deposit date:2015-03-09
Release date:2016-03-09
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.243 Å)
Cite:Structural and kinetic studies of the effect of guanine-N7 alkylation and metal cofactors on DNA replication.
Biochemistry, 2018
4NY8
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BU of 4ny8 by Molmil
DNA polymerase beta with O6mG in the template base opposite to incoming non-hydrolyzable CTP with manganese in the active site
Descriptor: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine, 5'-D(*CP*CP*GP*AP*CP*(6OG)P*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*A)-3', ...
Authors:Koag, M.-C, Min, K, Monzingo, A.F, Lee, S.
Deposit date:2013-12-10
Release date:2014-04-16
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.246 Å)
Cite:Metal-dependent conformational activation explains highly promutagenic replication across O6-methylguanine by human DNA polymerase beta.
J.Am.Chem.Soc., 136, 2014
4RQ6
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BU of 4rq6 by Molmil
Human DNA Polymerase Beta With Gapped DNA Containing an 8-oxo-7,8-dihydro-Guanine(8-oxoG) and dATP soaked with MgCl2 for 80 s
Descriptor: ACETATE ION, DNA (5'-D(*CP*CP*GP*AP*CP*(8OG)P*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*CP*A)-3'), ...
Authors:Vyas, R, Suo, Z.
Deposit date:2014-10-31
Release date:2015-04-15
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Viewing Human DNA Polymerase beta Faithfully and Unfaithfully Bypass an Oxidative Lesion by Time-Dependent Crystallography.
J.Am.Chem.Soc., 137, 2015
4R66
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BU of 4r66 by Molmil
Ternary complex crystal structure of E295K mutant of DNA polymerase Beta
Descriptor: 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, CHLORIDE ION, DNA (5'-D(*CP*CP*GP*AP*CP*AP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), ...
Authors:Batra, V.K, Beard, W.A, Wilson, S.H.
Deposit date:2014-08-22
Release date:2014-10-08
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Substrate-induced DNA Polymerase beta Activation.
J.Biol.Chem., 289, 2014
5DBB
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BU of 5dbb by Molmil
Structure of human DNA polymerase beta Host-Guest complex with the dG base paired with a dA
Descriptor: DNA (5'-D(*CP*CP*GP*AP*CP*GP*TP*CP*GP*CP*AP*TP*AP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*A)-3'), DNA (5'-D(P*GP*TP*CP*GP*G)-3'), ...
Authors:Koag, M.C, Lee, S.
Deposit date:2015-08-21
Release date:2015-11-11
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:N7 Methylation Alters Hydrogen-Bonding Patterns of Guanine in Duplex DNA.
J.Am.Chem.Soc., 137, 2015
4F5Q
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BU of 4f5q by Molmil
Closed ternary complex of R283K DNA polymerase beta
Descriptor: 2'-deoxy-5'-O-[(S)-{difluoro[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}(hydroxy)phosphoryl]cytidine, DNA (5'-D(*CP*CP*GP*AP*CP*GP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(P*GP*CP*TP*GP*AP*TP*GP*CP*GP*C)-3'), ...
Authors:Freudenthal, B.D, Beard, W.A, Wilson, S.H.
Deposit date:2012-05-13
Release date:2012-12-12
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structures of dNTP Intermediate States during DNA Polymerase Active Site Assembly.
Structure, 20, 2012
4PGY
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BU of 4pgy by Molmil
Structure of human DNA polymerase beta complexed with a nicked DNA containing a GT at N-1 position and GC at N position
Descriptor: DNA (5'-D(*CP*CP*GP*AP*CP*GP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*TP*C)-3'), DNA (5'-D(P*GP*TP*CP*GP*G)-3'), ...
Authors:Koag, M.C, Lee, S.
Deposit date:2014-05-03
Release date:2015-05-06
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:The spontaneous base substitution mechanisms of human DNA polymerase beta
To Be Published
6E3R
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BU of 6e3r by Molmil
Structure of human DNA polymerase beta complexed with 8OA as the template base in a 1-nucleotide gapped DNA
Descriptor: DNA (5'-D(*CP*CP*GP*AP*CP*(A38) P*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*A)-3'), DNA (5'-D(P*GP*TP*CP*GP*G)-3'), ...
Authors:Koag, M.-C, Lee, S.
Deposit date:2018-07-14
Release date:2019-04-03
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Mutagenic Replication of the Major Oxidative Adenine Lesion 7,8-Dihydro-8-oxoadenine by Human DNA Polymerases.
J. Am. Chem. Soc., 141, 2019
4NLN
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BU of 4nln by Molmil
Structure of human DNA polymerase beta complexed with nicked DNA containing a template 8BrG and incoming CTP
Descriptor: 5'-D(*CP*CP*GP*AP*CP*(BGM)P*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*AP*C)-3', 5'-D(P*GP*TP*CP*GP*G)-3', ...
Authors:Koag, M.-C, Min, K, Monzingo, A.F, Lee, S.
Deposit date:2013-11-14
Release date:2014-01-22
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.261 Å)
Cite:Structural basis for promutagenicity of 8-halogenated Guanine.
J.Biol.Chem., 289, 2014
4MFA
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BU of 4mfa by Molmil
Structure of human DNA polymerase beta complexed with nicked DNA containing a mismatched template O6MG and incoming TTP
Descriptor: DNA polymerase beta, MAGNESIUM ION, PHOSPHATE ION, ...
Authors:Koag, M.C, Min, K, Monzingo, A.F, Lee, S.
Deposit date:2013-08-27
Release date:2014-08-27
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Structures of human DNA polymerase beta inserting bases opposite templating O6MG
To be Published
4M2Y
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BU of 4m2y by Molmil
Structure of human DNA polymerase beta complexed with 8-BrG as the template base in a 1-nucleotide gapped DNA
Descriptor: DNA polymerase beta, SODIUM ION, down-primer, ...
Authors:Koag, M.C, Min, K, Monzingo, A.F, Lee, S.
Deposit date:2013-08-05
Release date:2014-01-22
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Structural basis for promutagenicity of 8-halogenated Guanine.
J.Biol.Chem., 289, 2014
4M9N
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BU of 4m9n by Molmil
DNA Polymerase Beta E295K Soaked with dATP
Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA Downstream Strand, DNA Primer Strand, ...
Authors:Eckenroth, B.E, Doublie, S.
Deposit date:2013-08-14
Release date:2013-10-16
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.275 Å)
Cite:The E295K Cancer Variant of Human Polymerase beta Favors the Mismatch Conformational Pathway during Nucleotide Selection.
J.Biol.Chem., 288, 2013
6CR7
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BU of 6cr7 by Molmil
Ternary complex crystal structure of DNA polymerase Beta with a dideoxy terminated primer with CHF, beta, gamma dATP analogue
Descriptor: 9-{2-deoxy-5-O-[(R)-{[(R)-[(R)-fluoro(phosphono)methyl](hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]-alpha-D-erythro-pentofuranosyl}-9H-purin-6-amine, CHLORIDE ION, DNA polymerase beta, ...
Authors:Batra, V.K, Wilson, S.H.
Deposit date:2018-03-16
Release date:2018-07-04
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:Mapping Functional Substrate-Enzyme Interactions in the pol beta Active Site through Chemical Biology: Structural Responses to Acidity Modification of Incoming dNTPs.
Biochemistry, 57, 2018
4O9M
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BU of 4o9m by Molmil
Human DNA polymerase beta complexed with adenylated tetrahydrofuran (abasic site) containing DNA
Descriptor: (5'-D(P*GP*TP*CP*GP*G)-3');, DNA (5'-D(*CP*CP*GP*AP*CP*AP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*CP*C)-3'), ...
Authors:Caglayan, M, Batra, V.K, Sassa, A, Prasad, R, Wilson, S.H.
Deposit date:2014-01-02
Release date:2014-04-30
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.295 Å)
Cite:Role of polymerase beta in complementing aprataxin deficiency during abasic-site base excision repair.
Nat.Struct.Mol.Biol., 21, 2014
6CRC
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BU of 6crc by Molmil
Ternary complex crystal structure of DNA polymerase Beta with a dideoxy terminated primer with CCL2, beta, gamma dATP analogue
Descriptor: 2'-deoxy-5'-O-[(R)-{[(R)-[dichloro(phosphono)methyl](hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]adenosine, DNA polymerase beta, Downstream Primer Strand, ...
Authors:Batra, V.K, Wilson, S.H.
Deposit date:2018-03-16
Release date:2018-07-25
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Mapping Functional Substrate-Enzyme Interactions in the pol beta Active Site through Chemical Biology: Structural Responses to Acidity Modification of Incoming dNTPs.
Biochemistry, 57, 2018
6U2O
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BU of 6u2o by Molmil
Structure of human DNA polymerase beta misinserting dAMPNPP opposite the 5'G of the cisplatin Pt-GG intrastrand crosslink
Descriptor: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, Cisplatin, DNA (5'-D(*CP*CP*CP*AP*CP*GP*GP*CP*CP*CP*AP*TP*CP*AP*CP*C)-3'), ...
Authors:Ouzon-Shubeita, H, Vilas, C.K, Lee, S.
Deposit date:2019-08-20
Release date:2020-08-26
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structures of the Mutagenic Bypass of the Major Cisplatin-DNA Lesion by Human DNA Polymerase Beta Reveal Insights into Cisplatin-Induced Mutagenesis
To Be Published
4PGQ
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BU of 4pgq by Molmil
Structure of human DNA polymerase beta complexed with G in the template base paired with incoming non-hydrolyzable TTP
Descriptor: 5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]thymidine, DNA (5'-D(*CP*CP*GP*AP*CP*GP*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*A)-3'), ...
Authors:Koag, M.C, Lee, S.
Deposit date:2014-05-02
Release date:2014-10-01
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The spontaneous replication error and the mismatch discrimination mechanisms of human DNA polymerase beta.
Nucleic Acids Res., 42, 2015
5J2H
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BU of 5j2h by Molmil
Ternary complex crystal structure of DNA polymerase Beta with G:T mismatch at the primer terminus
Descriptor: 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, CHLORIDE ION, DNA polymerase beta, ...
Authors:Batra, V.K, Wilson, S.H.
Deposit date:2016-03-29
Release date:2016-10-26
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structures of DNA Polymerase Mispaired DNA Termini Transitioning to Pre-catalytic Complexes Support an Induced-Fit Fidelity Mechanism.
Structure, 24, 2016
5U2S
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BU of 5u2s by Molmil
Pre-catalytic ternary complex of Human DNA Polymerase Beta With Gapped DNA substrate incoming (-)3TC-TP and Ca2+.
Descriptor: 10- MER PRIMER, 16- MER TEMPLATE, 5-MER PHOSPHORYLATED DOWNSTREAM PRIMER, ...
Authors:Vyas, R, Suo, Z.
Deposit date:2016-11-30
Release date:2017-05-24
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis for the D-stereoselectivity of human DNA polymerase beta.
Nucleic Acids Res., 45, 2017
3RJI
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BU of 3rji by Molmil
Ternary complex of DNA Polymerase Beta with a gapped DNA containing 8odG at template position paired with non-hydrolyzable dCTP analog (dCMP(CF2)PP)
Descriptor: 2'-deoxy-5'-O-[(S)-{difluoro[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}(hydroxy)phosphoryl]cytidine, CHLORIDE ION, DNA (5'-D(*CP*CP*GP*AP*CP*(8OG)P*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), ...
Authors:Batra, V.K, Beard, W.A, Wilson, S.H.
Deposit date:2011-04-15
Release date:2012-01-18
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Binary complex crystal structure of DNA polymerase beta reveals multiple conformations of the templating 8-oxoguanine lesion
Proc.Natl.Acad.Sci.USA, 109, 2012
3RJF
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BU of 3rjf by Molmil
Ternary complex of DNA Polymerase Beta with a gapped DNA containing (syn)8odG at template position paired with non-hydrolyzable dATP analog (dApCPP)
Descriptor: 2'-deoxy-5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl]adenosine, CHLORIDE ION, DNA (5'-D(*CP*CP*GP*AP*CP*(8OG)P*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), ...
Authors:Batra, V.K, Beard, W.A, Wilson, S.H.
Deposit date:2011-04-15
Release date:2012-01-18
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Binary complex crystal structure of DNA polymerase beta reveals multiple conformations of the templating 8-oxoguanine lesion
Proc.Natl.Acad.Sci.USA, 109, 2012
7S9M
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BU of 7s9m by Molmil
Crystal Structure of DNA Polymerase Beta with Ring open intermediate Fapy-dG base-paired with a dA
Descriptor: DNA (5'-D(*CP*CP*GP*AP*CP*GP*GP*CP*GP*CP*AP*TP*(IFP)P*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*AP*AP*TP*GP*CP*GP*C)-3'), DNA (5'-D(P*GP*TP*CP*GP*G)-3'), ...
Authors:Freudenthal, B.D, Ryan, B.J.
Deposit date:2021-09-21
Release date:2022-08-03
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Structural Dynamics of a Common Mutagenic Oxidative DNA Lesion in Duplex DNA and during DNA Replication.
J.Am.Chem.Soc., 144, 2022

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