4YN4

Structure of human DNA polymerase beta complexed with N7BG in the template opposite to incoming non-hydrolyzable dTTP WITH MANGANESE IN THE ACTIVE SITE

Summary for 4YN4

• Entry DOI: 10.2210/pdb4yn4/pdb
• Related: 4YMM 4YMN 4YMO
• Descriptor: DNA polymerase beta, DNA 16-mer (template), DNA 10-mer (up-primer), ... (8 entities in total)
• Functional Keywords: human dna polymerase beta, transferase-dna complex, transferase/dna
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 48453.04

Authors

Lee, S.,Koag, M.-C. (deposition date: 2015-03-09, release date: 2016-03-09, Last modification date: 2024-02-28)

• Primary citation: Kou, Y.,Koag, M.C.,Lee, S.; Structural and kinetic studies of the effect of guanine-N7 alkylation and metal cofactors on DNA replication.; Biochemistry, 2018; PubMed: 29957995; DOI: 10.1021/acs.biochem.8b00331

Experimental method

X-RAY DIFFRACTION (2.243 Å)