7S9O

Binary complex of DNA Polymerase Beta with Ring open Intermediate Fapy-dG in the template position

Summary for 7S9O

• Entry DOI: 10.2210/pdb7s9o/pdb
• Descriptor: DNA polymerase beta, DNA (5'-D(*CP*CP*GP*AP*C*(IFP)P*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*A*(SO4))-3'), ... (6 entities in total)
• Functional Keywords: fapy-dg intermediate, polymerase beta, dna binding protein-dna complex, dna binding protein/dna
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 47795.88

Authors

Freudenthal, B.D.,Ryan, B.J. (deposition date: 2021-09-21, release date: 2022-08-03, Last modification date: 2023-10-18)

• Primary citation: Ryan, B.J.,Yang, H.,Bacurio, J.H.T.,Smith, M.R.,Basu, A.K.,Greenberg, M.M.,Freudenthal, B.D.; Structural Dynamics of a Common Mutagenic Oxidative DNA Lesion in Duplex DNA and during DNA Replication.; J.Am.Chem.Soc., 144:8054-8065, 2022; PubMed: 35499923; DOI: 10.1021/jacs.2c00193

Experimental method

X-RAY DIFFRACTION (2.23 Å)