6U2O

Structure of human DNA polymerase beta misinserting dAMPNPP opposite the 5'G of the cisplatin Pt-GG intrastrand crosslink

Summary for 6U2O

• Entry DOI: 10.2210/pdb6u2o/pdb
• Descriptor: DNA polymerase beta, DNA (5'-D(*CP*CP*CP*AP*CP*GP*GP*CP*CP*CP*AP*TP*CP*AP*CP*C)-3'), DNA (5'-D(*GP*GP*TP*GP*AP*TP*GP*GP*GP*C)-3'), ... (9 entities in total)
• Functional Keywords: polymerase, cisplatin, mismatch, pt-gg, transferase, transferase-dna complex, transferase/dna
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 48568.40

Authors

Ouzon-Shubeita, H.,Vilas, C.K.,Lee, S. (deposition date: 2019-08-20, release date: 2020-08-26, Last modification date: 2023-10-11)

• Primary citation: Ouzon-Shubeita, H.,Vilas, C.K.,Lee, S.; Structures of the Mutagenic Bypass of the Major Cisplatin-DNA Lesion by Human DNA Polymerase Beta Reveal Insights into Cisplatin-Induced Mutagenesis; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.3 Å)