5FGU
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![BU of 5fgu by Molmil](/molmil-images/mine/5fgu) | Structure of Sda1 nuclease apoprotein as an EGFP fixed-arm fusion | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, Green fluorescent protein,Extracellular streptodornase D, ... | Authors: | Moon, A.F, Krahn, J.M, Xun, L, Cuneo, M.J, Pedersen, L.C. | Deposit date: | 2015-12-21 | Release date: | 2016-03-30 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.896 Å) | Cite: | Structural characterization of the virulence factor Sda1 nuclease from Streptococcus pyogenes. Nucleic Acids Res., 44, 2016
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5FGW
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![BU of 5fgw by Molmil](/molmil-images/mine/5fgw) | Structure of Sda1 nuclease with bound zinc ion | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, CHLORIDE ION, ... | Authors: | Moon, A.F, Krahn, J.M, Xun, L, Cuneo, M.J, Pedersen, L.C. | Deposit date: | 2015-12-21 | Release date: | 2016-03-30 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Structural characterization of the virulence factor Sda1 nuclease from Streptococcus pyogenes. Nucleic Acids Res., 44, 2016
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4X9E
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![BU of 4x9e by Molmil](/molmil-images/mine/4x9e) | DEOXYGUANOSINETRIPHOSPHATE TRIPHOSPHOHYDROLASE from Escherichia coli with two DNA effector molecules | Descriptor: | Deoxyguanosinetriphosphate triphosphohydrolase, MAGNESIUM ION, RNA (5'-R(P*CP*CP*C)-3') | Authors: | Singh, D, Gawel, D, Itsko, M, Krahn, J.M, London, R.E, Schaaper, R.M. | Deposit date: | 2014-12-11 | Release date: | 2015-02-25 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structure of Escherichia coli dGTP Triphosphohydrolase: A HEXAMERIC ENZYME WITH DNA EFFECTOR MOLECULES. J.Biol.Chem., 290, 2015
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8V54
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![BU of 8v54 by Molmil](/molmil-images/mine/8v54) | Engaged conformation of the human mitochondrial DNA polymerase gamma bound to DNA | Descriptor: | DNA (25-MER), DNA (44-MER), DNA polymerase subunit gamma-1, ... | Authors: | Riccio, A.A, Krahn, J.M, Bouvette, J, Borgnia, J.M, Copeland, W.C. | Deposit date: | 2023-11-30 | Release date: | 2024-07-10 | Last modified: | 2024-07-31 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Coordinated DNA polymerization by Pol gamma and the region of LonP1 regulated proteolysis. Nucleic Acids Res., 52, 2024
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8V5R
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![BU of 8v5r by Molmil](/molmil-images/mine/8v5r) | Active conformation of DNA polymerase gamma bound to DNA | Descriptor: | 2',3'-DIDEOXY-THYMIDINE-5'-TRIPHOSPHATE, DNA polymerase subunit gamma-1, DNA polymerase subunit gamma-2, ... | Authors: | Riccio, A.A, Krahn, J.M, Bouvette, J, Borgnia, J.M, Copeland, W.C. | Deposit date: | 2023-11-30 | Release date: | 2024-07-10 | Last modified: | 2024-07-31 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Coordinated DNA polymerization by Pol gamma and the region of LonP1 regulated proteolysis. Nucleic Acids Res., 52, 2024
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5T0A
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![BU of 5t0a by Molmil](/molmil-images/mine/5t0a) | Crystal Structure of Heparan Sulfate 6-O-Sulfotransferase with bound PAP and heptasaccharide substrate | Descriptor: | 1,2-ETHANEDIOL, 2-deoxy-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-4)-2-deoxy-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid, ADENOSINE-3'-5'-DIPHOSPHATE, ... | Authors: | Pedersen, L.C, Moon, A.F, Krahn, J.M, Liu, J. | Deposit date: | 2016-08-15 | Release date: | 2017-02-01 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Structure Based Substrate Specificity Analysis of Heparan Sulfate 6-O-Sulfotransferases. ACS Chem. Biol., 12, 2017
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5T05
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![BU of 5t05 by Molmil](/molmil-images/mine/5t05) | Crystal structure of heparan sulfate 6-O-sulfotransferase with bound PAP and IdoA2S containing hexasaccharide substrate | Descriptor: | 1,2-ETHANEDIOL, 2-deoxy-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-4)-2-deoxy-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid, ADENOSINE-3'-5'-DIPHOSPHATE, ... | Authors: | Pedersen, L.C, Moon, A.F, krahn, J.M, Liu, J. | Deposit date: | 2016-08-15 | Release date: | 2017-02-01 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.952 Å) | Cite: | Structure Based Substrate Specificity Analysis of Heparan Sulfate 6-O-Sulfotransferases. ACS Chem. Biol., 12, 2017
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5T03
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![BU of 5t03 by Molmil](/molmil-images/mine/5t03) | Crystal structure of heparan sulfate 6-O-sulfotransferase with bound PAP and glucuronic acid containing hexasaccharide substrate | Descriptor: | 1,2-ETHANEDIOL, 2-deoxy-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-4)-2-deoxy-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-4)-2-deoxy-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid, ADENOSINE-3'-5'-DIPHOSPHATE, ... | Authors: | Pedersen, L.C, Moon, A.F, Krahn, J.M, Liu, J. | Deposit date: | 2016-08-15 | Release date: | 2017-02-01 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structure Based Substrate Specificity Analysis of Heparan Sulfate 6-O-Sulfotransferases. ACS Chem. Biol., 12, 2017
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7N06
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![BU of 7n06 by Molmil](/molmil-images/mine/7n06) | SARS-CoV-2 Nsp15 endoribonuclease post-cleavage state | Descriptor: | RNA (5'-R(*AP*UP*A)-3'), Uridylate-specific endoribonuclease | Authors: | Frazier, M.N, Dillard, L.B, Krahn, J.M, Stanley, R.E. | Deposit date: | 2021-05-25 | Release date: | 2021-06-02 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (2.2 Å) | Cite: | Characterization of SARS2 Nsp15 nuclease activity reveals it's mad about U. Nucleic Acids Res., 49, 2021
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7N33
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![BU of 7n33 by Molmil](/molmil-images/mine/7n33) | SARS-CoV-2 Nsp15 endoribonuclease pre-cleavage state | Descriptor: | RNA (5'-R(*A)-D(*(UFT))-R(P*A)-3'), Uridylate-specific endoribonuclease | Authors: | Frazier, M.N, Dillard, L.B, Krahn, J.M, Stanley, R.E. | Deposit date: | 2021-05-31 | Release date: | 2021-06-09 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (2.5 Å) | Cite: | Characterization of SARS2 Nsp15 nuclease activity reveals it's mad about U. Nucleic Acids Res., 49, 2021
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1XSL
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![BU of 1xsl by Molmil](/molmil-images/mine/1xsl) | Crystal Structure of human DNA polymerase lambda in complex with a one nucleotide DNA gap | Descriptor: | 5'-D(*CP*GP*GP*CP*AP*GP*CP*GP*CP*AP*C)-3', 5'-D(*GP*TP*GP*CP*GP*C)-3', 5'-D(P*GP*CP*CP*G)-3', ... | Authors: | Garcia-Diaz, M, Bebenek, K, Krahn, J.M, Kunkel, T.A, Pedersen, L.C. | Deposit date: | 2004-10-19 | Release date: | 2005-01-18 | Last modified: | 2018-01-24 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | A closed conformation for the Pol lambda catalytic cycle. Nat.Struct.Mol.Biol., 12, 2005
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1XSN
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![BU of 1xsn by Molmil](/molmil-images/mine/1xsn) | Crystal Structure of human DNA polymerase lambda in complex with a one nucleotide DNA gap and ddTTP | Descriptor: | 1,2-ETHANEDIOL, 2',3'-DIDEOXY-THYMIDINE-5'-TRIPHOSPHATE, 5'-D(*CP*AP*GP*TP*AP*(2DT))-3', ... | Authors: | Garcia-Diaz, M, Bebenek, K, Krahn, J.M, Kunkel, T.A, Pedersen, L.C. | Deposit date: | 2004-10-19 | Release date: | 2005-01-18 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | A closed conformation for the Pol lambda catalytic cycle. Nat.Struct.Mol.Biol., 12, 2005
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1XSP
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![BU of 1xsp by Molmil](/molmil-images/mine/1xsp) | Crystal Structure of human DNA polymerase lambda in complex with nicked DNA and pyrophosphate | Descriptor: | 5'-D(*CP*AP*GP*TP*AP*CP*G)-3', 5'-D(*CP*GP*GP*CP*CP*GP*TP*AP*CP*TP*G)-3', 5'-D(P*GP*CP*CP*G)-3', ... | Authors: | Garcia-Diaz, M, Bebenek, K, Krahn, J.M, Kunkel, T.A, Pedersen, L.C. | Deposit date: | 2004-10-19 | Release date: | 2005-01-18 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | A closed conformation for the Pol lambda catalytic cycle. Nat.Struct.Mol.Biol., 12, 2005
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6OF3
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![BU of 6of3 by Molmil](/molmil-images/mine/6of3) | Precursor ribosomal RNA processing complex, State 1. | Descriptor: | CLP1_P domain-containing protein, MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... | Authors: | Pillon, M.C, Hsu, A.L, Krahn, J.M, Williams, J.G, Goslen, K.H, Sobhany, M, Borgnia, M.J, Stanley, R.E. | Deposit date: | 2019-03-28 | Release date: | 2019-09-11 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Cryo-EM reveals active site coordination within a multienzyme pre-rRNA processing complex. Nat.Struct.Mol.Biol., 26, 2019
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6OF4
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![BU of 6of4 by Molmil](/molmil-images/mine/6of4) | Precursor ribosomal RNA processing complex, apo-state. | Descriptor: | CLP1_P domain-containing protein, Ribonuclease | Authors: | Pillon, M.C, Hsu, A.L, Krahn, J.M, Williams, J.G, Goslen, K.H, Sobhany, M, Borgnia, M.J, Stanley, R.E. | Deposit date: | 2019-03-28 | Release date: | 2019-09-11 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Cryo-EM reveals active site coordination within a multienzyme pre-rRNA processing complex. Nat.Struct.Mol.Biol., 26, 2019
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6Q00
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![BU of 6q00 by Molmil](/molmil-images/mine/6q00) | TDP2 UBA Domain Bound to Ubiquitin at 0.85 Angstroms Resolution, Crystal Form 1 | Descriptor: | POTASSIUM ION, Tyrosyl-DNA phosphodiesterase 2, Ubiquitin | Authors: | Schellenberg, M.J, Krahn, J.M, Williams, R.S. | Deposit date: | 2019-08-01 | Release date: | 2020-04-29 | Last modified: | 2020-06-24 | Method: | X-RAY DIFFRACTION (0.85 Å) | Cite: | Ubiquitin stimulated reversal of topoisomerase 2 DNA-protein crosslinks by TDP2. Nucleic Acids Res., 48, 2020
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6Q01
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![BU of 6q01 by Molmil](/molmil-images/mine/6q01) | TDP2 UBA Domain Bound to Ubiquitin at 0.85 Angstroms Resolution, Crystal Form 2 | Descriptor: | 1,2-ETHANEDIOL, BENZOIC ACID, MAGNESIUM ION, ... | Authors: | Schellenberg, M.J, Krahn, J.M, Williams, R.S. | Deposit date: | 2019-08-01 | Release date: | 2020-04-29 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (0.851 Å) | Cite: | Ubiquitin stimulated reversal of topoisomerase 2 DNA-protein crosslinks by TDP2. Nucleic Acids Res., 48, 2020
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4DD8
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![BU of 4dd8 by Molmil](/molmil-images/mine/4dd8) | ADAM-8 metalloproteinase domain with bound batimastat | Descriptor: | 4-(N-HYDROXYAMINO)-2R-ISOBUTYL-2S-(2-THIENYLTHIOMETHYL)SUCCINYL-L-PHENYLALANINE-N-METHYLAMIDE, CALCIUM ION, CHLORIDE ION, ... | Authors: | Hall, T, Shieh, H.S, Day, J.E, Caspers, N, Chrencik, J.E, Williams, J.M, Pegg, L.E, Pauley, A.M, Moon, A.F, Krahn, J.M, Fischer, D.H, Kiefer, J.R, Tomasselli, A.G, Zack, M.D. | Deposit date: | 2012-01-18 | Release date: | 2012-06-06 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structure of human ADAM-8 catalytic domain complexed with batimastat. Acta Crystallogr.,Sect.F, 68, 2012
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4IM8
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![BU of 4im8 by Molmil](/molmil-images/mine/4im8) | low resolution crystal structure of mouse RAGE | Descriptor: | Advanced glycation end-products receptor | Authors: | Xu, D, Young, J.H, Krahn, J.M, Song, D, Corbett, K.D, Chazin, W.J, Pedersen, L.C, Esko, J.D. | Deposit date: | 2013-01-02 | Release date: | 2013-08-14 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.503 Å) | Cite: | Stable RAGE-Heparan Sulfate Complexes Are Essential for Signal Transduction. Acs Chem.Biol., 8, 2013
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3UAN
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![BU of 3uan by Molmil](/molmil-images/mine/3uan) | Crystal structure of 3-O-sulfotransferase (3-OST-1) with bound PAP and heptasaccharide substrate | Descriptor: | 2-acetamido-2-deoxy-6-O-sulfo-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, 2-acetamido-2-deoxy-6-O-sulfo-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid, ADENOSINE-3'-5'-DIPHOSPHATE, ... | Authors: | Moon, A.F, Xu, Y, Woody, S.M, Krahn, J.M, Linhardt, R.J, Liu, J, Pedersen, L.C. | Deposit date: | 2011-10-21 | Release date: | 2012-04-04 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.844 Å) | Cite: | Dissecting the substrate recognition of 3-O-sulfotransferase for the biosynthesis of anticoagulant heparin. Proc.Natl.Acad.Sci.USA, 109, 2012
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1YRM
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![BU of 1yrm by Molmil](/molmil-images/mine/1yrm) | |
1YZD
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![BU of 1yzd by Molmil](/molmil-images/mine/1yzd) | |
7TQV
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![BU of 7tqv by Molmil](/molmil-images/mine/7tqv) | SARS-CoV-2 endoribonuclease Nsp15 bound to dsRNA | Descriptor: | RNA (33-MER), Uridylate-specific endoribonuclease | Authors: | Frazier, M.N, Krahn, J.M, Butay, K.J, Dillard, L.B, Borgnia, M.J, Stanley, R.E. | Deposit date: | 2022-01-27 | Release date: | 2022-03-23 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.43 Å) | Cite: | Flipped over U: structural basis for dsRNA cleavage by the SARS-CoV-2 endoribonuclease. Nucleic Acids Res., 50, 2022
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7TJ2
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![BU of 7tj2 by Molmil](/molmil-images/mine/7tj2) | SARS-CoV-2 endoribonuclease Nsp15 bound to dsRNA | Descriptor: | RNA (31-MER), Uridylate-specific endoribonuclease nsp15 | Authors: | Frazier, M.N, Krahn, J.M, Butay, K.J, Dillard, L.B, Borgnia, M.J, Stanley, R.E. | Deposit date: | 2022-01-14 | Release date: | 2022-03-23 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Flipped over U: structural basis for dsRNA cleavage by the SARS-CoV-2 endoribonuclease. Nucleic Acids Res., 50, 2022
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7SCD
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![BU of 7scd by Molmil](/molmil-images/mine/7scd) | Ternary complex of fixed-arm Trx-3ost5 (I299E) with 8mer-1 octasaccharide substrate and co-factor product PAP | Descriptor: | 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid, ADENOSINE-3'-5'-DIPHOSPHATE, Thioredoxin 1,Heparan sulfate glucosamine 3-O-sulfotransferase 5 | Authors: | Wander, R, Kaminski, A.M, Krahn, J.M, Liu, J, Pedersen, L.C. | Deposit date: | 2021-09-27 | Release date: | 2022-01-19 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structural and Substrate Specificity Analysis of 3-O-Sulfotransferase Isoform 5 to Synthesize Heparan Sulfate Acs Catalysis, 11, 2021
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