3UAN

Crystal structure of 3-O-sulfotransferase (3-OST-1) with bound PAP and heptasaccharide substrate

Summary for 3UAN

• Entry DOI: 10.2210/pdb3uan/pdb
• Related: 1T8T 1T8U 1ZRH
• Descriptor: Heparan sulfate glucosamine 3-O-sulfotransferase 1, 2-acetamido-2-deoxy-6-O-sulfo-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid, 2-acetamido-2-deoxy-6-O-sulfo-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, ... (6 entities in total)
• Functional Keywords: sulfotransferase, heparan sulfate, alpha/beta motif, co-factor paps/pap, heparan sulfate oligosaccharides, golgi-localized, transferase
• Biological source: Mus musculus (mouse)
• Cellular location: Golgi apparatus lumen (Probable): O35310
• Total number of polymer chains: 2
• Total formula weight: 66784.72

Authors

Moon, A.F.,Xu, Y.,Woody, S.M.,Krahn, J.M.,Linhardt, R.J.,Liu, J.,Pedersen, L.C. (deposition date: 2011-10-21, release date: 2012-04-04, Last modification date: 2023-09-13)

• Primary citation: Moon, A.F.,Xu, Y.,Woody, S.M.,Krahn, J.M.,Linhardt, R.J.,Liu, J.,Pedersen, L.C.; Dissecting the substrate recognition of 3-O-sulfotransferase for the biosynthesis of anticoagulant heparin.; Proc.Natl.Acad.Sci.USA, 109:5265-5270, 2012; PubMed: 22431632; DOI: 10.1073/pnas.1117923109

Experimental method

X-RAY DIFFRACTION (1.844 Å)