8T7C
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![BU of 8t7c by Molmil](/molmil-images/mine/8t7c) | Crystal structure of human phospholipase C gamma 2 | Descriptor: | 1,2-ETHANEDIOL, 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2, CALCIUM ION | Authors: | Chen, Y, Choi, H, Zhuang, N, Hu, L, Qian, D, Wang, J. | Deposit date: | 2023-06-20 | Release date: | 2024-06-26 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | The crystal and cryo-EM structures of PLCg2 reveal dynamic inter-domain recognitions in autoinhibition To Be Published
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8GV7
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![BU of 8gv7 by Molmil](/molmil-images/mine/8gv7) | Crystal structure of PN-SIA28 in complex with influenza hemagglutinin H18 A/flat-faced bat/Peru/033/2010 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin H18-HA1, ... | Authors: | Chen, Y, Song, H, Qi, J, Gao, G.F. | Deposit date: | 2022-09-14 | Release date: | 2022-12-21 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural basis for a human broadly neutralizing influenza A hemagglutinin stem-specific antibody including H17/18 subtypes. Nat Commun, 13, 2022
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8GK7
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![BU of 8gk7 by Molmil](/molmil-images/mine/8gk7) | MsbA bound to cerastecin C | Descriptor: | 2-[(4-butylbenzene-1-sulfonyl)amino]-5-[(3-{4-[(4-butylbenzene-1-sulfonyl)amino]-3-carboxyanilino}-3-oxopropyl)carbamoyl]benzoic acid, Lipid A export ATP-binding/permease protein MsbA, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | Authors: | Chen, Y, Klein, D. | Deposit date: | 2023-03-17 | Release date: | 2024-04-24 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.32 Å) | Cite: | Cerastecins inhibit membrane lipooligosaccharide transport in drug-resistant Acinetobacter baumannii. Nat Microbiol, 9, 2024
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7EQT
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![BU of 7eqt by Molmil](/molmil-images/mine/7eqt) | |
7EQS
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![BU of 7eqs by Molmil](/molmil-images/mine/7eqs) | |
7EQW
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![BU of 7eqw by Molmil](/molmil-images/mine/7eqw) | |
7ER1
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![BU of 7er1 by Molmil](/molmil-images/mine/7er1) | |
7ER0
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![BU of 7er0 by Molmil](/molmil-images/mine/7er0) | |
8GV5
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![BU of 8gv5 by Molmil](/molmil-images/mine/8gv5) | Crystal structure of PN-SIA28 in complex with influenza hemagglutinin A/swine/Guangdong/104/2013 (H1N1) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin HA1 chain, Hemagglutinin HA2 chain, ... | Authors: | Chen, Y, Song, H, Qi, J, Gao, G.F. | Deposit date: | 2022-09-14 | Release date: | 2022-12-21 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structural basis for a human broadly neutralizing influenza A hemagglutinin stem-specific antibody including H17/18 subtypes. Nat Commun, 13, 2022
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7FJD
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![BU of 7fjd by Molmil](/molmil-images/mine/7fjd) | Cryo-EM structure of a membrane protein(WT) | Descriptor: | CHOLESTEROL, T cell receptor alpha variable 12-3,Possible J 11 gene segment,T cell receptor alpha chain constant, T cell receptor beta variable 6-5,M1-specific T cell receptor beta chain,T cell receptor beta constant 2, ... | Authors: | Chen, Y, Zhu, Y, Gao, W, Zhang, A, Guo, C, Huang, Z. | Deposit date: | 2021-08-03 | Release date: | 2022-07-27 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Cholesterol inhibits TCR signaling by directly restricting TCR-CD3 core tunnel motility. Mol.Cell, 82, 2022
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7FJE
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![BU of 7fje by Molmil](/molmil-images/mine/7fje) | Cryo-EM structure of a membrane protein(LL) | Descriptor: | CHOLESTEROL, T cell receptor alpha variable 12-3,Possible J 11 gene segment,T cell receptor alpha chain constant, T cell receptor beta variable 6-5,M1-specific T cell receptor beta chain,T cell receptor beta constant 2, ... | Authors: | Chen, Y, Zhu, Y, Gao, W, Zhang, A, Guo, C, Huang, Z. | Deposit date: | 2021-08-03 | Release date: | 2022-07-27 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Cholesterol inhibits TCR signaling by directly restricting TCR-CD3 core tunnel motility. Mol.Cell, 82, 2022
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7FJF
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![BU of 7fjf by Molmil](/molmil-images/mine/7fjf) | Cryo-EM structure of a membrane protein(CS) | Descriptor: | CHOLEST-5-EN-3-YL HYDROGEN SULFATE, T cell receptor alpha variable 12-3,Possible J 11 gene segment,T cell receptor alpha chain constant, T cell receptor beta variable 6-5,M1-specific T cell receptor beta chain,T cell receptor beta constant 2, ... | Authors: | Chen, Y, Zhu, Y, Gao, W, Zhang, A, Guo, C, Huang, Z. | Deposit date: | 2021-08-03 | Release date: | 2022-07-27 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Cholesterol inhibits TCR signaling by directly restricting TCR-CD3 core tunnel motility. Mol.Cell, 82, 2022
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8KGO
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8GV6
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![BU of 8gv6 by Molmil](/molmil-images/mine/8gv6) | Crystal structure of PN-SIA28 in complex with influenza hemagglutinin H14 (A/long-tailed duck/Wisconsin/10OS3912/2010) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin H14-HA1, ... | Authors: | Chen, Y, Song, H, Qi, J, Gao, G.F. | Deposit date: | 2022-09-14 | Release date: | 2022-12-21 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Structural basis for a human broadly neutralizing influenza A hemagglutinin stem-specific antibody including H17/18 subtypes. Nat Commun, 13, 2022
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8GV4
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![BU of 8gv4 by Molmil](/molmil-images/mine/8gv4) | A human broadly neutralizing influenza A hemagglutinin stem-specific antibody PN-SIA28 | Descriptor: | PN-SIA28 heavy chain, PN-SIA28 light chain | Authors: | Chen, Y, Song, H, Qi, J, Gao, G.F. | Deposit date: | 2022-09-14 | Release date: | 2022-12-21 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural basis for a human broadly neutralizing influenza A hemagglutinin stem-specific antibody including H17/18 subtypes. Nat Commun, 13, 2022
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7DDC
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![BU of 7ddc by Molmil](/molmil-images/mine/7ddc) | Crystal structure of SARS-CoV-2 main protease in complex with Tafenoquine | Descriptor: | 3C-like proteinase, Tafenoquine | Authors: | Chen, Y, Wang, Y.C, Yang, C.S, Hung, M.C. | Deposit date: | 2020-10-28 | Release date: | 2021-11-10 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.175 Å) | Cite: | Tafenoquine and its derivatives as inhibitors for the severe acute respiratory syndrome coronavirus 2. J.Biol.Chem., 298, 2022
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6KHY
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![BU of 6khy by Molmil](/molmil-images/mine/6khy) | The crystal structure of AsfvAP:AG | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, DNA (AGCGTCACCGACGAGGC), DNA(AGCGTCACCGACGAGG), ... | Authors: | Chen, Y.Q, Gan, J.H. | Deposit date: | 2019-07-16 | Release date: | 2020-06-03 | Method: | X-RAY DIFFRACTION (3.008 Å) | Cite: | A unique DNA-binding mode of African swine fever virus AP endonuclease. Cell Discov, 6, 2020
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2HKO
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![BU of 2hko by Molmil](/molmil-images/mine/2hko) | Crystal structure of LSD1 | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, Lysine-specific histone demethylase 1 | Authors: | Chen, Y, Yang, Y.T, Wang, F, Yanane, K, Zhang, Y, Lei, M. | Deposit date: | 2006-07-05 | Release date: | 2006-08-29 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal structure of human histone lysine-specific demethylase 1 (LSD1). Proc.Natl.Acad.Sci.Usa, 103, 2006
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8CTM
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![BU of 8ctm by Molmil](/molmil-images/mine/8ctm) | |
7X4A
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![BU of 7x4a by Molmil](/molmil-images/mine/7x4a) | Native CD-NTase ClCdnE | Descriptor: | ClCdnE | Authors: | Chen, Y, Ko, T.P, Yang, C.S, Wang, Y.C, Hou, M.H. | Deposit date: | 2022-03-02 | Release date: | 2023-03-08 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.21 Å) | Cite: | Crystal structure and functional implications of cyclic di-pyrimidine-synthesizing cGAS/DncV-like nucleotidyltransferases. Nat Commun, 14, 2023
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7X4G
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![BU of 7x4g by Molmil](/molmil-images/mine/7x4g) | CD-NTase ClCdnE in complex with substrate UTP | Descriptor: | ClCdnE, MAGNESIUM ION, URIDINE 5'-TRIPHOSPHATE | Authors: | Chen, Y, Ko, T.P, Yang, C.S, Wang, Y.C, Hou, M.H. | Deposit date: | 2022-03-02 | Release date: | 2023-03-08 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Crystal structure and functional implications of cyclic di-pyrimidine-synthesizing cGAS/DncV-like nucleotidyltransferases. Nat Commun, 14, 2023
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8CZZ
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![BU of 8czz by Molmil](/molmil-images/mine/8czz) | Cryo-EM structure of T/F100 SOSIP.664 HIV-1 Env trimer with LMHS mutations in complex with Temsavir, 8ANC195, and 10-1074 | Descriptor: | 1-[4-(benzenecarbonyl)piperazin-1-yl]-2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]ethane-1,2-dione, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Chen, Y, Pozharski, E, Tolbert, W, Pazgier, M. | Deposit date: | 2022-05-25 | Release date: | 2023-05-31 | Last modified: | 2023-11-08 | Method: | ELECTRON MICROSCOPY (3.14 Å) | Cite: | Structure-function analyses reveal key molecular determinants of HIV-1 CRF01_AE resistance to the entry inhibitor temsavir. Nat Commun, 14, 2023
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7UL1
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![BU of 7ul1 by Molmil](/molmil-images/mine/7ul1) | Crystal structure of SARS-CoV-2 RBD in complex with the neutralizing IGHV3-53-encoded antibody EH3 isolated from a nonvaccinated pediatric patient | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of EH3, Light chain of EH3, ... | Authors: | Chen, Y, Tolbert, W.D, Pazgier, M. | Deposit date: | 2022-04-03 | Release date: | 2023-03-08 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Molecular basis for antiviral activity of two pediatric neutralizing antibodies targeting SARS-CoV-2 Spike RBD. Iscience, 26, 2023
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7UL0
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![BU of 7ul0 by Molmil](/molmil-images/mine/7ul0) | Crystal structure of SARS-CoV-2 RBD in complex with the ridge-binding nAb EH8 isolated from a nonvaccinated pediatric patient | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of EH8, ... | Authors: | Chen, Y, Tolbert, W.D, Bai, X, Pazgier, M. | Deposit date: | 2022-04-03 | Release date: | 2023-03-08 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.49 Å) | Cite: | Molecular basis for antiviral activity of two pediatric neutralizing antibodies targeting SARS-CoV-2 Spike RBD. Iscience, 26, 2023
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8DOK
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![BU of 8dok by Molmil](/molmil-images/mine/8dok) | Cryo-EM structure of T/F100 SOSIP.664 HIV-1 Env trimer in complex with 8ANC195 and 10-1074 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Chen, Y, Zhou, F, Huang, R, Tolbert, W, Pazgier, M. | Deposit date: | 2022-07-13 | Release date: | 2023-07-19 | Last modified: | 2023-11-08 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structure-function analyses reveal key molecular determinants of HIV-1 CRF01_AE resistance to the entry inhibitor temsavir. Nat Commun, 14, 2023
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