7UL0

Crystal structure of SARS-CoV-2 RBD in complex with the ridge-binding nAb EH8 isolated from a nonvaccinated pediatric patient

Summary for 7UL0

• Entry DOI: 10.2210/pdb7ul0/pdb
• Descriptor: Spike protein S1, Heavy chain of EH8, Light chain of EH8, ... (7 entities in total)
• Functional Keywords: pediatric neutralizing mab, rbd-ridge-targeting, bind to both closed and open sars-cov-2 spike, class-2 rbd-binding antibody, viral protein, viral protein-immune system complex, viral protein/immune system
• Biological source: Severe acute respiratory syndrome coronavirus 2; More
• Total number of polymer chains: 3
• Total formula weight: 72263.48

Authors

Chen, Y.,Tolbert, W.D.,Bai, X.,Pazgier, M. (deposition date: 2022-04-03, release date: 2023-03-08, Last modification date: 2023-10-25)

• Primary citation: Chen, Y.,Prevost, J.,Ullah, I.,Romero, H.,Lisi, V.,Tolbert, W.D.,Grover, J.R.,Ding, S.,Gong, S.Y.,Beaudoin-Bussieres, G.,Gasser, R.,Benlarbi, M.,Vezina, D.,Anand, S.P.,Chatterjee, D.,Goyette, G.,Grunst, M.W.,Yang, Z.,Bo, Y.,Zhou, F.,Beland, K.,Bai, X.,Zeher, A.R.,Huang, R.K.,Nguyen, D.N.,Sherburn, R.,Wu, D.,Piszczek, G.,Pare, B.,Matthies, D.,Xia, D.,Richard, J.,Kumar, P.,Mothes, W.,Cote, M.,Uchil, P.D.,Lavallee, V.P.,Smith, M.A.,Pazgier, M.,Haddad, E.,Finzi, A.; Molecular basis for antiviral activity of two pediatric neutralizing antibodies targeting SARS-CoV-2 Spike RBD.; Iscience, 26:105783-105783, 2023; PubMed: 36514310; DOI: 10.1016/j.isci.2022.105783

Experimental method

X-RAY DIFFRACTION (2.49 Å)