7DDC

Crystal structure of SARS-CoV-2 main protease in complex with Tafenoquine

Summary for 7DDC

• Entry DOI: 10.2210/pdb7ddc/pdb
• Descriptor: 3C-like proteinase, Tafenoquine (3 entities in total)
• Functional Keywords: main protease, 3c-like proteinase, viral protein
• Biological source: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV)
• Total number of polymer chains: 1
• Total formula weight: 34346.09

Authors

Chen, Y.,Wang, Y.C.,Yang, C.S.,Hung, M.C. (deposition date: 2020-10-28, release date: 2021-11-10, Last modification date: 2023-11-29)

• Primary citation: Chen, Y.,Yang, W.H.,Chen, H.F.,Huang, L.M.,Gao, J.Y.,Lin, C.W.,Wang, Y.C.,Yang, C.S.,Liu, Y.L.,Hou, M.H.,Tsai, C.L.,Chou, Y.Z.,Huang, B.Y.,Hung, C.F.,Hung, Y.L.,Wang, W.J.,Su, W.C.,Kumar, V.,Wu, Y.C.,Chao, S.W.,Chang, C.S.,Chen, J.S.,Chiang, Y.P.,Cho, D.Y.,Jeng, L.B.,Tsai, C.H.,Hung, M.C.; Tafenoquine and its derivatives as inhibitors for the severe acute respiratory syndrome coronavirus 2.; J.Biol.Chem., 298:101658-101658, 2022; PubMed: 35101449; DOI: 10.1016/j.jbc.2022.101658

Experimental method

X-RAY DIFFRACTION (2.175 Å)