6U4N
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6U4M
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![BU of 6u4m by Molmil](/molmil-images/mine/6u4m) | Solution structure of paxillin LIM4 | Descriptor: | Paxillin, ZINC ION | Authors: | Zhu, L, Qin, J. | Deposit date: | 2019-08-26 | Release date: | 2019-10-23 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Structural Basis of Paxillin Recruitment by Kindlin-2 in Regulating Cell Adhesion. Structure, 27, 2019
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7KXT
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![BU of 7kxt by Molmil](/molmil-images/mine/7kxt) | Crystal structure of human EED | Descriptor: | 1-[(4-fluorophenyl)methyl]-N-{1-[2-(4-methoxyphenyl)ethyl]piperidin-4-yl}-1H-benzimidazol-2-amine, Polycomb protein EED, UNKNOWN ATOM OR ION | Authors: | Zhu, L, Dong, A, Du, D, Liu, Y, Luo, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | Deposit date: | 2020-12-04 | Release date: | 2021-02-24 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Structure-Guided Development of Small-Molecule PRC2 Inhibitors Targeting EZH2-EED Interaction. J.Med.Chem., 64, 2021
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5GKA
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![BU of 5gka by Molmil](/molmil-images/mine/5gka) | cryo-EM structure of human Aichi virus | Descriptor: | Genome polyprotein, capsid protein VP0, capsid protein VP1 | Authors: | Zhu, L, Wang, X.X, Ren, J.S, Tuthill, T.J, Fry, E.E, Rao, Z.H, Stuart, D.I. | Deposit date: | 2016-07-04 | Release date: | 2016-09-21 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Structure of human Aichi virus and implications for receptor binding Nat Microbiol, 1, 2016
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3SNC
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3SNA
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3SNB
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3SN8
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3SNE
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3SND
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3TIU
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![BU of 3tiu by Molmil](/molmil-images/mine/3tiu) | Crystal structure of SARS coronavirus main protease complexed with an alpha,beta-unsaturated ethyl ester inhibitor SG82 | Descriptor: | DIMETHYL SULFOXIDE, ETHYL (5S,8S,11R)-8-BENZYL-5-(3-TERT-BUTOXY-3-OXOPROPYL)-3,6,9-TRIOXO-11-{[(3S)-2-OXOPYRROLIDIN-3-YL]METHYL}-1-PHENYL-2-OXA-4,7,10-TRIAZATETRADECAN-14-OATE, SARS coronavirus main protease | Authors: | Zhu, L, Hilgenfeld, R. | Deposit date: | 2011-08-22 | Release date: | 2012-08-22 | Last modified: | 2017-11-08 | Method: | X-RAY DIFFRACTION (2.08 Å) | Cite: | Crystal structures of SARS-Cov main protease complexed with a series of peptidic unsaturated esters To be Published
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3TIT
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3TNT
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3SZN
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3TNS
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![BU of 3tns by Molmil](/molmil-images/mine/3tns) | Crystal structure of SARS coronavirus main protease complexed with an alpha, beta-unsaturated ethyl ester inhibitor SG83 | Descriptor: | ETHYL (5S,8S,11R)-8-BENZYL-5-(2-TERT-BUTOXY-2-OXOETHYL)-3,6,9-TRIOXO-11-{[(3S)-2-OXOPYRROLIDIN-3-YL]METHYL}-1-PHENYL-2-OXA-4,7,10-TRIAZATETRADECAN-14-OATE, SARS coronavirus main protease | Authors: | Zhu, L, Hilgenfeld, R. | Deposit date: | 2011-09-01 | Release date: | 2012-09-05 | Last modified: | 2017-11-08 | Method: | X-RAY DIFFRACTION (1.99 Å) | Cite: | Crystal structures of SARS-Cov main protease complexed with a series of peptidic unsaturated esters To be Published
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6M2B
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![BU of 6m2b by Molmil](/molmil-images/mine/6m2b) | Crystal structure of human dihydroorotate dehydrogenase (DHODH) with S416 | Descriptor: | 2-[(E)-[[4-(2-chlorophenyl)-1,3-thiazol-2-yl]-methyl-hydrazinylidene]methyl]benzoic acid, Dihydroorotate dehydrogenase (quinone), mitochondrial, ... | Authors: | Zhu, L, Li, H. | Deposit date: | 2020-02-27 | Release date: | 2021-03-03 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.76 Å) | Cite: | Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2. Protein Cell, 11, 2020
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6BA6
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![BU of 6ba6 by Molmil](/molmil-images/mine/6ba6) | Solution structure of Rap1b/talin complex | Descriptor: | Ras-related protein Rap-1b, Talin-1 | Authors: | Zhu, L, Yang, J, Qin, J. | Deposit date: | 2017-10-12 | Release date: | 2017-12-06 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Structure of Rap1b bound to talin reveals a pathway for triggering integrin activation. Nat Commun, 8, 2017
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6M6E
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6M6F
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5ZID
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![BU of 5zid by Molmil](/molmil-images/mine/5zid) | Crystal Structure of human DPP-IV in complex with HL2 | Descriptor: | (2S,3R)-2-amino-9-methoxy-3-(2,4,5-trifluorophenyl)-2,3-dihydro-1H-naphtho[2,1-b]pyran-8-carbonitrile, 2-acetamido-2-deoxy-beta-D-glucopyranose, Dipeptidyl peptidase 4, ... | Authors: | Zhu, L, Li, H, Wu, F. | Deposit date: | 2018-03-14 | Release date: | 2019-03-20 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Crystal Structure of human DPP-IV in complex with HL2 To Be Published
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7WYF
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6KU8
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![BU of 6ku8 by Molmil](/molmil-images/mine/6ku8) | structure of HRV-C 3C protein with rupintrivir | Descriptor: | 4-{2-(4-FLUORO-BENZYL)-6-METHYL-5-[(5-METHYL-ISOXAZOLE-3-CARBONYL)-AMINO]-4-OXO-HEPTANOYLAMINO}-5-(2-OXO-PYRROLIDIN-3-YL)-PENTANOIC ACID ETHYL ESTER, Genome polyprotein | Authors: | Zhu, L, Yuan, S. | Deposit date: | 2019-08-31 | Release date: | 2020-03-25 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Structure of the HRV-C 3C-Rupintrivir Complex Provides New Insights for Inhibitor Design. Virol Sin, 35, 2020
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6KU7
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![BU of 6ku7 by Molmil](/molmil-images/mine/6ku7) | structure of HRV-C 3C protein | Descriptor: | Genome polyprotein | Authors: | Zhu, L, Yuan, S. | Deposit date: | 2019-08-31 | Release date: | 2020-03-25 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Structure of the HRV-C 3C-Rupintrivir Complex Provides New Insights for Inhibitor Design. Virol Sin, 35, 2020
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8WD8
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![BU of 8wd8 by Molmil](/molmil-images/mine/8wd8) | Cryo-EM structure of TtdAgo-guide DNA-target DNA complex | Descriptor: | Argonaute family protein, Guide DNA, MAGNESIUM ION, ... | Authors: | Zhuang, L. | Deposit date: | 2023-09-14 | Release date: | 2024-01-31 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Molecular mechanism for target recognition, dimerization, and activation of Pyrococcus furiosus Argonaute. Mol.Cell, 84, 2024
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8JPX
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![BU of 8jpx by Molmil](/molmil-images/mine/8jpx) | Cryo-EM structure of PfAgo-guide DNA-target DNA complex | Descriptor: | Excess DNA, Guide DNA, MAGNESIUM ION, ... | Authors: | Zhuang, L. | Deposit date: | 2023-06-13 | Release date: | 2024-01-31 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Molecular mechanism for target recognition, dimerization, and activation of Pyrococcus furiosus Argonaute. Mol.Cell, 84, 2024
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