7FB8
| De Novo-Designed and Disulfide-Bridged Peptide Heterodimer - hd1 | Descriptor: | ASP-ASP-LYS-ASP-CYS-ASP-GLU-TYR-CYS-LYS-LYS-THR-LYS-GLU-NH2, GLU-LE1-THR-GLY-HIS-ILE-GLU-GLY-PRO-THR-LE1-THR-LE1-HIS-CYS-LYS-NH2 | Authors: | Yao, H, Yao, S, Zheng, Y, Moyer, A, Baker, D, Wu, C. | Deposit date: | 2021-07-08 | Release date: | 2022-05-18 | Last modified: | 2023-11-15 | Method: | SOLUTION NMR | Cite: | De novo design and directed folding of disulfide-bridged peptide heterodimers. Nat Commun, 13, 2022
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5XRF
| Crystal structure of Da-36, a thrombin-like enzyme from Deinagkistrodon acutus | Descriptor: | DI(HYDROXYETHYL)ETHER, Snake venom serine protease Da-36, alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Lin, C.-C, Wu, W.-G, Fan, Q, Tian, J, Zhang, Z, Zheng, Y. | Deposit date: | 2017-06-08 | Release date: | 2018-06-13 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structure of Da-36, a thrombin-like enzyme from Deinagkistrodon acutus To Be Published
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7C2J
| Crystal structure of nsp16-nsp10 heterodimer from SARS-CoV-2 in complex with SAM (without additional SAM during crystallization) | Descriptor: | 2'-O-methyltransferase, Non-structural protein 10, S-ADENOSYLMETHIONINE, ... | Authors: | Lin, S, Chen, H, Ye, F, Chen, Z.M, Yang, F.L, Zheng, Y, Cao, Y, Qiao, J.X, Yang, S.Y, Lu, G.W. | Deposit date: | 2020-05-07 | Release date: | 2020-05-27 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.799 Å) | Cite: | Crystal structure of SARS-CoV-2 nsp10/nsp16 2'-O-methylase and its implication on antiviral drug design. Signal Transduct Target Ther, 5, 2020
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7C2I
| Crystal structure of nsp16-nsp10 heterodimer from SARS-CoV-2 in complex with SAM (with additional SAM during crystallization) | Descriptor: | 2'-O-methyltransferase, Non-structural protein 10, S-ADENOSYLMETHIONINE, ... | Authors: | Lin, S, Chen, H, Ye, F, Chen, Z.M, Yang, F.L, Zheng, Y, Cao, Y, Qiao, J.X, Yang, S.Y, Lu, G.W. | Deposit date: | 2020-05-07 | Release date: | 2020-05-27 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal structure of SARS-CoV-2 nsp10/nsp16 2'-O-methylase and its implication on antiviral drug design. Signal Transduct Target Ther, 5, 2020
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7DIY
| Crystal structure of SARS-CoV-2 nsp10 bound to nsp14-exoribonuclease domain | Descriptor: | MAGNESIUM ION, ZINC ION, nsp10 protein, ... | Authors: | Lin, S, Chen, H, Chen, Z.M, Yang, F.L, Ye, F, Zheng, Y, Yang, J, Lin, X, Sun, H.L, Wang, L.L, Wen, A, Cao, Y, Lu, G.W. | Deposit date: | 2020-11-19 | Release date: | 2021-05-19 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.693 Å) | Cite: | Crystal structure of SARS-CoV-2 nsp10 bound to nsp14-ExoN domain reveals an exoribonuclease with both structural and functional integrity. Nucleic Acids Res., 49, 2021
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7VNQ
| Structure of human KCNQ4-ML213 complex in nanodisc | Descriptor: | (1S,2S,4R)-N-(2,4,6-trimethylphenyl)bicyclo[2.2.1]heptane-2-carboxamid, Calmodulin-3, POTASSIUM ION, ... | Authors: | Xu, F, Zheng, Y. | Deposit date: | 2021-10-11 | Release date: | 2021-12-01 | Last modified: | 2022-02-16 | Method: | ELECTRON MICROSCOPY (2.96 Å) | Cite: | Structural insights into the lipid and ligand regulation of a human neuronal KCNQ channel. Neuron, 110, 2022
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7ULU
| Human DDAH1 soaked with its inhibitor ClPyrAA | Descriptor: | (2S)-2-amino-4-[(pyridin-2-yl)amino]butanoic acid, N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 | Authors: | Butrin, A, Zheng, Y, Tuley, A, Liu, D, Fast, W. | Deposit date: | 2022-04-05 | Release date: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Optimization of a switchable electrophile fragment into a potent and selective covalent inhibitor of human DDAH1 To Be Published
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7VNR
| Structure of human KCNQ4-ML213 complex in digitonin | Descriptor: | (1S,2S,4R)-N-(2,4,6-trimethylphenyl)bicyclo[2.2.1]heptane-2-carboxamid, Calmodulin-3, POTASSIUM ION, ... | Authors: | Xu, F, Zheng, Y. | Deposit date: | 2021-10-11 | Release date: | 2021-12-01 | Last modified: | 2022-02-16 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Structural insights into the lipid and ligand regulation of a human neuronal KCNQ channel. Neuron, 110, 2022
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7VNP
| Structure of human KCNQ4-ML213 complex with PIP2 | Descriptor: | (1S,2S,4R)-N-(2,4,6-trimethylphenyl)bicyclo[2.2.1]heptane-2-carboxamid, Calmodulin-3, POTASSIUM ION, ... | Authors: | Xu, F, Zheng, Y. | Deposit date: | 2021-10-11 | Release date: | 2021-12-01 | Last modified: | 2022-02-16 | Method: | ELECTRON MICROSCOPY (2.79 Å) | Cite: | Structural insights into the lipid and ligand regulation of a human neuronal KCNQ channel. Neuron, 110, 2022
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4NFO
| Crystal Structure Analysis of the 16mer GCAGACUUAAGUCUGC | Descriptor: | GCAGACUUAAGUCUGC, SPERMINE | Authors: | Beal, P.A, Fisher, A.J, Phelps, K.J, Ibarra-Soza, J.M, Zheng, Y. | Deposit date: | 2013-10-31 | Release date: | 2014-07-02 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.96 Å) | Cite: | Click Modification of RNA at Adenosine: Structure and Reactivity of 7-Ethynyl- and 7-Triazolyl-8-aza-7-deazaadenosine in RNA. Acs Chem.Biol., 9, 2014
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4NFP
| Crystal Structure Analysis of the 16mer GCAGNCUUAAGUCUGC containing 8-aza-7-deaza-7-ethynyl Adenosine | Descriptor: | FORMAMIDE, GCAG(A7E)CUUAAGUCUGC | Authors: | Beal, P.A, Fisher, A.J, Phelps, K.J, Ibarra-Soza, J.M, Zheng, Y. | Deposit date: | 2013-10-31 | Release date: | 2014-07-02 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Click Modification of RNA at Adenosine: Structure and Reactivity of 7-Ethynyl- and 7-Triazolyl-8-aza-7-deazaadenosine in RNA. Acs Chem.Biol., 9, 2014
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4NFQ
| Crystal Structure Analysis of the 16mer GCAGNCUUAAGUCUGC containing 7-triazolyl-8-aza-7-deazaadenosine | Descriptor: | GCAG(7AT)CUUAAGUCUGC | Authors: | Beal, P.A, Fisher, A.J, Phelps, K.J, Ibarra-Soza, J.M, Zheng, Y. | Deposit date: | 2013-10-31 | Release date: | 2014-07-02 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Click Modification of RNA at Adenosine: Structure and Reactivity of 7-Ethynyl- and 7-Triazolyl-8-aza-7-deazaadenosine in RNA. Acs Chem.Biol., 9, 2014
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