7VNP

Structure of human KCNQ4-ML213 complex with PIP2

Summary for 7VNP

• Entry DOI: 10.2210/pdb7vnp/pdb
• EMDB information: 32044
• Descriptor: Potassium voltage-gated channel subfamily KQT member 4,Maltodextrin-binding protein, Calmodulin-3, [(2R)-1-octadecanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phospho ryl]oxy-propan-2-yl] (8Z)-icosa-5,8,11,14-tetraenoate, ... (5 entities in total)
• Functional Keywords: kcnq4, ml213, pip2, cryo-em, membrane protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 8
• Total formula weight: 543138.29

Authors

Xu, F.,Zheng, Y. (deposition date: 2021-10-11, release date: 2021-12-01, Last modification date: 2022-02-16)

• Primary citation: Zheng, Y.,Liu, H.,Chen, Y.,Dong, S.,Wang, F.,Wang, S.,Li, G.L.,Shu, Y.,Xu, F.; Structural insights into the lipid and ligand regulation of a human neuronal KCNQ channel.; Neuron, 110:237-, 2022; PubMed: 34767770; DOI: 10.1016/j.neuron.2021.10.029

Experimental method

ELECTRON MICROSCOPY (2.79 Å)