7ULU

Human DDAH1 soaked with its inhibitor ClPyrAA

Summary for 7ULU

• Entry DOI: 10.2210/pdb7ulu/pdb
• Descriptor: N(G),N(G)-dimethylarginine dimethylaminohydrolase 1, (2S)-2-amino-4-[(pyridin-2-yl)amino]butanoic acid (3 entities in total)
• Functional Keywords: ddah1, dimethylargininase, ddah, clpyraa, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 67637.42

Authors

Butrin, A.,Zheng, Y.,Tuley, A.,Liu, D.,Fast, W. (deposition date: 2022-04-05, release date: 2023-08-30)

• Primary citation: Tuley, A.,Zheng, Y.,Tommasi, S.,Butrin, A.,May, K.V.,Ahn, Y.,Reidl, T.C.,Weerakoon, L.,Hulin, J.,Meech, R.,Patel, D.S.,Horton, C.P.,Swartzel, C.J.,Kim, Y.,Silverman, B.R.,Mangoni, A.,Liu, D.,Fast, W.; Optimization of a switchable electrophile fragment into a potent and selective covalent inhibitor of human DDAH1; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.2 Å)