8XW0
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![BU of 8xw0 by Molmil](/molmil-images/mine/8xw0) | Cryo-EM structure of OSCA3.1-GDN state | Descriptor: | CSC1-like protein ERD4, O-[(R)-{[(2R)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-L-serine | Authors: | Zhang, Y, Han, Y. | Deposit date: | 2024-01-15 | Release date: | 2024-04-10 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (3.11 Å) | Cite: | Mechanical activation opens a lipid-lined pore in OSCA ion channels. Nature, 628, 2024
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8XS5
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![BU of 8xs5 by Molmil](/molmil-images/mine/8xs5) | |
8XW2
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![BU of 8xw2 by Molmil](/molmil-images/mine/8xw2) | |
8XW3
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![BU of 8xw3 by Molmil](/molmil-images/mine/8xw3) | |
8XAJ
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![BU of 8xaj by Molmil](/molmil-images/mine/8xaj) | Cryo-EM structure of OSCA1.2-liposome-inside-in open state | Descriptor: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Calcium permeable stress-gated cation channel 1 | Authors: | Zhang, Y, Han, Y. | Deposit date: | 2023-12-04 | Release date: | 2024-04-10 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (3.29 Å) | Cite: | Mechanical activation opens a lipid-lined pore in OSCA ion channels. Nature, 628, 2024
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7ST4
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![BU of 7st4 by Molmil](/molmil-images/mine/7st4) | Calcium-saturated jGCaMP8.410.80 | Descriptor: | CALCIUM ION, GLYCEROL, L(+)-TARTARIC ACID, ... | Authors: | Zhang, Y, Looger, L.L. | Deposit date: | 2021-11-11 | Release date: | 2022-11-16 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Fast and sensitive GCaMP calcium indicators for imaging neural populations Nature, 615, 2023
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7T1F
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![BU of 7t1f by Molmil](/molmil-images/mine/7t1f) | Crystal structure of GDP-bound T50I mutant of human KRAS4B | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, Isoform 2B of GTPase KRas, MAGNESIUM ION | Authors: | Zhang, Y, Zhang, C. | Deposit date: | 2021-12-01 | Release date: | 2022-12-14 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural and functional analyses of a germline KRAS T50I mutation provide insights into Raf activation. JCI Insight, 8, 2023
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5WMA
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![BU of 5wma by Molmil](/molmil-images/mine/5wma) | N-terminal bromodomain of BRD4 in complex with PLX5981 | Descriptor: | 1,2-ETHANEDIOL, 5-(3,5-dimethyl-1,2-oxazol-4-yl)-1H-pyrrolo[2,3-b]pyridine, Bromodomain-containing protein 4 | Authors: | Zhang, Y. | Deposit date: | 2017-07-28 | Release date: | 2018-08-01 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.401 Å) | Cite: | BRD4 Profiling Identifies Critical Chronic Lymphocytic Leukemia Oncogenic Circuits and Reveals Sensitivity to PLX51107, a Novel Structurally Distinct BET Inhibitor. Cancer Discov, 8, 2018
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4HS4
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![BU of 4hs4 by Molmil](/molmil-images/mine/4hs4) | Crystal structure of a putative chromate reductase from Gluconacetobacter hansenii, Gh-ChrR, containing a Y129N substitution. | Descriptor: | Chromate reductase, FLAVIN MONONUCLEOTIDE | Authors: | Zhang, Y, Robinson, H, Buchko, G.W. | Deposit date: | 2012-10-29 | Release date: | 2012-12-26 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Mechanistic insights of chromate and uranyl reduction by the NADPH-dependent FMN reductase, ChrR, from Gluconacetobacter hansenii To be Published
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2MNY
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![BU of 2mny by Molmil](/molmil-images/mine/2mny) | NMR Structure of KDM5B PHD1 finger | Descriptor: | Lysine-specific demethylase 5B, ZINC ION | Authors: | Zhang, Y, Yang, H.R, Guo, X, Rong, N.Y, Song, Y.J, Xu, Y.W, Lan, W.X, Xu, Y.H, Cao, C. | Deposit date: | 2014-04-16 | Release date: | 2014-08-06 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | The PHD1 finger of KDM5B recognizes unmodified H3K4 during the demethylation of histone H3K4me2/3 by KDM5B. Protein Cell, 5, 2014
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4L13
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2MNZ
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![BU of 2mnz by Molmil](/molmil-images/mine/2mnz) | NMR Structure of KDM5B PHD1 finger in complex with H3K4me0(1-10aa) | Descriptor: | H3K4me0, Lysine-specific demethylase 5B, ZINC ION | Authors: | Zhang, Y, Yang, H.R, Guo, X, Rong, N.Y, Song, Y.J, Xu, Y.W, Lan, W.X, Xu, Y.H, Cao, C. | Deposit date: | 2014-04-16 | Release date: | 2014-08-06 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | The PHD1 finger of KDM5B recognizes unmodified H3K4 during the demethylation of histone H3K4me2/3 by KDM5B. Protein Cell, 5, 2014
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6C00
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![BU of 6c00 by Molmil](/molmil-images/mine/6c00) | |
4OIP
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![BU of 4oip by Molmil](/molmil-images/mine/4oip) | Crystal structure of Thermus thermophilus transcription initiation complex soaked with GE23077, ATP, and CMPcPP | Descriptor: | (2Z)-2-methylbut-2-enoic acid, 5'-D(*CP*CP*TP*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*GP*G)-3', 5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G)-3', ... | Authors: | Zhang, Y, Ebright, R.H, Arnold, E. | Deposit date: | 2014-01-20 | Release date: | 2014-05-07 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | GE23077 binds to the RNA polymerase 'i' and 'i+1' sites and prevents the binding of initiating nucleotides. Elife, 3, 2014
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4H6P
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![BU of 4h6p by Molmil](/molmil-images/mine/4h6p) | Crystal structure of a putative chromate reductase from Gluconacetobacter hansenii, Gh-ChrR, containing a R101A substitution. | Descriptor: | Chromate reductase, FLAVIN MONONUCLEOTIDE | Authors: | Zhang, Y, Robinson, H, Buchko, G.W. | Deposit date: | 2012-09-19 | Release date: | 2012-10-10 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.556 Å) | Cite: | Mechanistic insights of chromate and uranyl reduction by the NADPH-dependent FMN reductase, ChrR, from Gluconacetobacter hansenii To be Published
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4OIQ
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![BU of 4oiq by Molmil](/molmil-images/mine/4oiq) | Crystal structure of Thermus thermophilus transcription initiation complex soaked with GE23077 and rifampicin | Descriptor: | (2Z)-2-methylbut-2-enoic acid, 5'-D(*CP*CP*T*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*GP*G)-3', 5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G)-3', ... | Authors: | Zhang, Y, Ebright, R.H, Arnold, E. | Deposit date: | 2014-01-20 | Release date: | 2014-05-07 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.624 Å) | Cite: | GE23077 binds to the RNA polymerase 'i' and 'i+1' sites and prevents the binding of initiating nucleotides. Elife, 3, 2014
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4OIN
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![BU of 4oin by Molmil](/molmil-images/mine/4oin) | Crystal structure of Thermus thermophilus transcription initiation complex soaked with GE23077 | Descriptor: | (2Z)-2-methylbut-2-enoic acid, 5'-D(*CP*CP*T*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*G)-3', 5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G)-3', ... | Authors: | Zhang, Y, Ebright, R.H, Arnold, E. | Deposit date: | 2014-01-20 | Release date: | 2014-05-07 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | GE23077 binds to the RNA polymerase 'i' and 'i+1' sites and prevents the binding of initiating nucleotides. Elife, 3, 2014
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4OIO
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![BU of 4oio by Molmil](/molmil-images/mine/4oio) | Crystal structure of Thermus thermophilus pre-insertion substrate complex for de novo transcription initiation | Descriptor: | 5'-D(*CP*CP*TP*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*GP*G)-3', 5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G)-3', 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl]cytidine, ... | Authors: | Zhang, Y, Ebright, R.H, Arnold, E. | Deposit date: | 2014-01-20 | Release date: | 2014-05-07 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | GE23077 binds to the RNA polymerase 'i' and 'i+1' sites and prevents the binding of initiating nucleotides. Elife, 3, 2014
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4OIR
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![BU of 4oir by Molmil](/molmil-images/mine/4oir) | Crystal structure of Thermus thermophilus RNA polymerase transcription initiation complex soaked with GE23077 and rifamycin SV | Descriptor: | (2Z)-2-methylbut-2-enoic acid, 5'-D(*CP*CP*T*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*GP*G)-3', 5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G)-3', ... | Authors: | Zhang, Y, Ebright, R.H, Arnold, E. | Deposit date: | 2014-01-20 | Release date: | 2014-05-07 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.105 Å) | Cite: | GE23077 binds to the RNA polymerase 'i' and 'i+1' sites and prevents the binding of initiating nucleotides. Elife, 3, 2014
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6M0X
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![BU of 6m0x by Molmil](/molmil-images/mine/6m0x) | Crystal structure of Streptococcus thermophilus Cas9 in complex with AGGA PAM | Descriptor: | BARIUM ION, CRISPR-associated endonuclease Cas9 1, DNA (28-MER), ... | Authors: | Zhang, Y, Zhang, H, Xu, X, Wang, Y, Chen, W, Wang, Y, Wu, Z, Tang, N, Wang, Y, Zhao, S, Gan, J, Ji, Q. | Deposit date: | 2020-02-23 | Release date: | 2020-09-09 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.561 Å) | Cite: | Catalytic-state structure and engineering of Streptococcus thermophilus Cas9 Nat Catal, 2020
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6M0V
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![BU of 6m0v by Molmil](/molmil-images/mine/6m0v) | Crsytal structure of streptococcus thermophilus Cas9 in complex with the GGAA PAM | Descriptor: | BARIUM ION, CRISPR-associated endonuclease Cas9 1, DNA (28-MER), ... | Authors: | Zhang, Y, Zhang, H, Xu, X, Wang, Y, Chen, W, Wang, Y, Wu, Z, Tang, N, Wang, Y, Zhao, S, Gan, J, Ji, Q. | Deposit date: | 2020-02-22 | Release date: | 2020-09-09 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Catalytic-state structure and engineering of Streptococcus thermophilus Cas9 Nat Catal, 2020
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6BGN
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![BU of 6bgn by Molmil](/molmil-images/mine/6bgn) | Crystal Structure of 4-Oxalocrotonate Tautomerase After Incubation with 5-Fluoro-2-hydroxy-2,4-pentadienoate | Descriptor: | 2-hydroxymuconate tautomerase, 5-fluoranyl-2-oxidanylidene-pentanoic acid, GLYCEROL, ... | Authors: | Zhang, Y, Li, W, Stack, T. | Deposit date: | 2017-10-29 | Release date: | 2018-02-21 | Last modified: | 2019-12-25 | Method: | X-RAY DIFFRACTION (1.51 Å) | Cite: | Inactivation of 4-Oxalocrotonate Tautomerase by 5-Halo-2-hydroxy-2,4-pentadienoates. Biochemistry, 57, 2018
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5WSH
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![BU of 5wsh by Molmil](/molmil-images/mine/5wsh) | Structure of HLA-A2 P130 | Descriptor: | Beta-2-microglobulin, DI(HYDROXYETHYL)ETHER, GLY-VAL-TRP-ILE-ARG-THR-PRO-THR-ALA, ... | Authors: | Zhang, Y, Wu, Y, Qi, J, Liu, J, Gao, G.F, Meng, S. | Deposit date: | 2016-12-07 | Release date: | 2017-12-20 | Last modified: | 2019-01-23 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | CD8+T-Cell Response-Associated Evolution of Hepatitis B Virus Core Protein and Disease Progress. J. Virol., 92, 2018
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5E00
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![BU of 5e00 by Molmil](/molmil-images/mine/5e00) | Structure of HLA-A2 P130 | Descriptor: | Beta-2-microglobulin, GLY-VAL-TRP-ILE-ARG-THR-PRO-PRO-ALA, HLA class I histocompatibility antigen, ... | Authors: | Zhang, Y, Wu, Y, Qi, J, Liu, J, Gao, G.F, Meng, S. | Deposit date: | 2015-09-26 | Release date: | 2017-01-18 | Last modified: | 2019-01-23 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | CD8+T-Cell Response-Associated Evolution of Hepatitis B Virus Core Protein and Disease Progress. J. Virol., 92, 2018
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5Y4O
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![BU of 5y4o by Molmil](/molmil-images/mine/5y4o) | Cryo-EM structure of MscS channel, YnaI | Descriptor: | Low conductance mechanosensitive channel YnaI | Authors: | Zhang, Y, Yu, J. | Deposit date: | 2017-08-04 | Release date: | 2019-03-20 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | A binding-block ion selective mechanism revealed by a Na/K selective channel. Protein Cell, 9, 2018
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