9ATN

NMR structure of the MLL4 PHD2/3 fingers in complex with ASXL2

Summary for 9ATN

• Entry DOI: 10.2210/pdb9atn/pdb
• Descriptor: Histone-lysine N-methyltransferase 2D, Polycomb group protein ASXL2, ZINC ION (3 entities in total)
• Functional Keywords: mll4, transcription, protein binding, transferase-protein binding complex, transferase/protein binding
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 13263.89

Authors

Zhang, Y.,Zandian, M.,Kutateladze, T. (deposition date: 2024-02-27, release date: 2024-06-19)

• Primary citation: Zhang, Y.,Xie, G.,Lee, J.E.,Zandian, M.,Sudarshan, D.,Estavoyer, B.,Benz, C.,Viita, T.,Asgaritarghi, G.,Lachance, C.,Messmer, C.,Simonetti, L.,Sinha, V.K.,Lambert, J.P.,Chen, Y.W.,Wang, S.P.,Ivarsson, Y.,Affar, E.B.,Cote, J.,Ge, K.,Kutateladze, T.G.; ASXLs binding to the PHD2/3 fingers of MLL4 provides a mechanism for the recruitment of BAP1 to active enhancers.; Nat Commun, 15:4883-4883, 2024; PubMed: 38849395; DOI: 10.1038/s41467-024-49391-x

Experimental method

SOLUTION NMR