4IAQ
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![BU of 4iaq by Molmil](/molmil-images/mine/4iaq) | Crystal structure of the chimeric protein of 5-HT1B-BRIL in complex with dihydroergotamine (PSI Community Target) | Descriptor: | Chimera protein of human 5-hydroxytryptamine receptor 1B and E. Coli soluble cytochrome b562, Dihydroergotamine | Authors: | Wang, C, Jiang, Y, Ma, J, Wu, H, Wacker, D, Katritch, V, Han, G.W, Liu, W, Huang, X, Vardy, E, McCorvy, J.D, Gao, X, Zhou, E.X, Melcher, K, Zhang, C, Bai, F, Yang, H, Yang, L, Jiang, H, Roth, B.L, Cherezov, V, Stevens, R.C, Xu, H.E, GPCR Network (GPCR) | Deposit date: | 2012-12-07 | Release date: | 2013-03-13 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural basis for molecular recognition at serotonin receptors. Science, 340, 2013
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5Z9J
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![BU of 5z9j by Molmil](/molmil-images/mine/5z9j) | Identification of the functions of unusual cytochrome p450-like monooxygenases involved in microbial secondary metablism | Descriptor: | PROTOPORPHYRIN IX CONTAINING FE, Putative P450-like enzyme, TRIS(HYDROXYETHYL)AMINOMETHANE | Authors: | Lu, M, Lin, L, Zhang, C, Chen, Y. | Deposit date: | 2018-02-03 | Release date: | 2019-02-06 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Riboflavin Is Directly Involved in the N-Dealkylation Catalyzed by Bacterial Cytochrome P450 Monooxygenases. Chembiochem, 2020
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4IAR
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![BU of 4iar by Molmil](/molmil-images/mine/4iar) | Crystal structure of the chimeric protein of 5-HT1B-BRIL in complex with ergotamine (PSI Community Target) | Descriptor: | (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Chimera protein of human 5-hydroxytryptamine receptor 1B and E. Coli soluble cytochrome b562, Ergotamine | Authors: | Wang, C, Jiang, Y, Ma, J, Wu, H, Wacker, D, Katritch, V, Han, G.W, Liu, W, Huang, X, Vardy, E, McCorvy, J.D, Gao, X, Zhou, E.X, Melcher, K, Zhang, C, Bai, F, Yang, H, Yang, L, Jiang, H, Roth, B.L, Cherezov, V, Stevens, R.C, Xu, H.E, GPCR Network (GPCR) | Deposit date: | 2012-12-07 | Release date: | 2013-03-13 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural basis for molecular recognition at serotonin receptors. Science, 340, 2013
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5XK4
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![BU of 5xk4 by Molmil](/molmil-images/mine/5xk4) | Retracted state of S65-phosphorylated ubiquitin | Descriptor: | Polyubiquitin-B | Authors: | Dong, X, Gong, Z, Qin, L.Y, Ran, M.L, Zhang, C.L, Liu, K, Liu, Z, Zhang, W.P, Tang, C. | Deposit date: | 2017-05-05 | Release date: | 2017-06-28 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Ubiquitin S65 phosphorylation engenders a pH-sensitive conformational switch Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5XK5
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![BU of 5xk5 by Molmil](/molmil-images/mine/5xk5) | Relaxed state of S65-phosphorylated ubiquitin | Descriptor: | Polyubiquitin-B | Authors: | Xu, D, Zhou, G, Qin, L.Y, Ran, M.L, Zhang, C.L, Liu, K, Liu, Z, Zhang, W.P, Tang, C. | Deposit date: | 2017-05-05 | Release date: | 2017-06-28 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Ubiquitin S65 phosphorylation engenders a pH-sensitive conformational switch Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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3PFT
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![BU of 3pft by Molmil](/molmil-images/mine/3pft) | Crystal Structure of Untagged C54A Mutant Flavin Reductase (DszD) in Complex with FMN From Mycobacterium goodii | Descriptor: | FLAVIN MONONUCLEOTIDE, Flavin reductase | Authors: | Li, Q, Xu, P, Ma, C, Gu, L, Liu, X, Zhang, C, Li, N, Su, J, Li, B, Liu, S. | Deposit date: | 2010-10-29 | Release date: | 2011-11-02 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.601 Å) | Cite: | The flavin reductase DSZD from a desulfurizing mycobacterium goodii strain: systemic manipulation and investigation based on the crystal structure To be Published
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4IH4
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![BU of 4ih4 by Molmil](/molmil-images/mine/4ih4) | Crystal structure of Arabidopsis DWARF14 orthologue, AtD14 | Descriptor: | AT3g03990/T11I18_10 | Authors: | Zhou, X.E, Zhao, L.-H, Wu, Z.-S, Yi, W, Li, S, Li, Y, Xu, Y, Xu, T.-H, Liu, Y, Chen, R.-Z, Kovach, A, Kang, Y, Hou, L, He, Y, Zhang, C, Melcher, K, Xu, H.E. | Deposit date: | 2012-12-18 | Release date: | 2013-01-30 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Crystal structures of two phytohormone signal-transducing alpha / beta hydrolases: karrikin-signaling KAI2 and strigolactone-signaling DWARF14. Cell Res., 23, 2013
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6AIJ
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![BU of 6aij by Molmil](/molmil-images/mine/6aij) | Cyclodextrin glycosyltransferase from Paenibacillus macerans mutant N603D | Descriptor: | CALCIUM ION, Cyclomaltodextrin glucanotransferase | Authors: | Li, C.M, Ban, X.F, Li, Z.F, Li, Y.L, Cheng, S.D, Zhang, C.Y, Jin, T.C, Gu, Z.B. | Deposit date: | 2018-08-24 | Release date: | 2018-10-10 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.096 Å) | Cite: | Cyclodextrin glycosyltransferase from Paenibacillus macerans mutant N603D To Be Published
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5FBH
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![BU of 5fbh by Molmil](/molmil-images/mine/5fbh) | Crystal structure of the extracellular domain of human calcium sensing receptor with bound Gd3+ | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, BICARBONATE ION, CHLORIDE ION, ... | Authors: | Zhang, T, Zhang, C, Miller, C.L, Zou, J, Moremen, K.W, Brown, E.M, Yang, J.J, Hu, J. | Deposit date: | 2015-12-14 | Release date: | 2016-06-22 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural basis for regulation of human calcium-sensing receptor by magnesium ions and an unexpected tryptophan derivative co-agonist. Sci Adv, 2, 2016
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5FBK
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![BU of 5fbk by Molmil](/molmil-images/mine/5fbk) | Crystal structure of the extracellular domain of human calcium sensing receptor | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, BICARBONATE ION, CHLORIDE ION, ... | Authors: | Zhang, T, Zhang, C, Miller, C.L, Zou, J, Moremen, K.W, Brown, E.M, Yang, J.J, Hu, J. | Deposit date: | 2015-12-14 | Release date: | 2016-06-22 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural basis for regulation of human calcium-sensing receptor by magnesium ions and an unexpected tryptophan derivative co-agonist. Sci Adv, 2, 2016
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5ZIU
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![BU of 5ziu by Molmil](/molmil-images/mine/5ziu) | Crystal structure of human Entervirus D68 RdRp | Descriptor: | DI(HYDROXYETHYL)ETHER, GLYCEROL, RdRp | Authors: | Wang, M.L, Zhang, Y, Chen, Y.P, Lu, D.R, Jiang, H, Chen, Y.J, Li, L, Zhang, C.H, Shi, Q.L, Su, D. | Deposit date: | 2018-03-17 | Release date: | 2019-04-17 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.147 Å) | Cite: | Crystal structure of human Entervirus D68 RdRp in complex with NADPH To Be Published
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3PDS
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![BU of 3pds by Molmil](/molmil-images/mine/3pds) | Irreversible Agonist-Beta2 Adrenoceptor Complex | Descriptor: | 8-hydroxy-5-[(1R)-1-hydroxy-2-({2-[3-methoxy-4-(3-sulfanylpropoxy)phenyl]ethyl}amino)ethyl]quinolin-2(1H)-one, CHOLESTEROL, Fusion protein Beta-2 adrenergic receptor/Lysozyme, ... | Authors: | Rosenbaum, D.M, Zhang, C, Lyons, J.A, Holl, R, Aragao, D, Arlow, D.H, Rasmussen, S.G.F, Choi, H.-J, DeVree, B.T, Sunahara, R.K, Chae, P.S, Gellman, S.H, Dror, R.O, Shaw, D.E, Weis, W.I, Caffrey, M, Gmeiner, P, Kobilka, B.K. | Deposit date: | 2010-10-24 | Release date: | 2011-01-12 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Structure and function of an irreversible agonist-beta(2) adrenoceptor complex Nature, 469, 2011
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7NFA
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![BU of 7nfa by Molmil](/molmil-images/mine/7nfa) | The structure of the humanised A33 Fab C226S variant, an immunotherapy candidate for colorectal cancer | Descriptor: | A33 Fab heavy chain, A33 Fab light chain | Authors: | Tang, J, Zhang, C, Dalby, P, Kozielski, F. | Deposit date: | 2021-02-05 | Release date: | 2022-03-02 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | The structure of the humanised A33 Fab C226S variant, an immunotherapy candidate for colorectal cancer To Be Published
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8G05
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![BU of 8g05 by Molmil](/molmil-images/mine/8g05) | Cryo-EM structure of an orphan GPCR-Gi protein signaling complex | Descriptor: | 6-(octylamino)pyrimidine-2,4(3H,5H)-dione, CHOLESTEROL, G-protein coupled receptor 84, ... | Authors: | Zhang, X, Wang, Y.J, Li, X, Liu, G.B, Gong, W.M, Zhang, C. | Deposit date: | 2023-01-31 | Release date: | 2023-11-01 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Pro-phagocytic function and structural basis of GPR84 signaling. Nat Commun, 14, 2023
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4IH9
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![BU of 4ih9 by Molmil](/molmil-images/mine/4ih9) | Crystal structure of rice DWARF14 (D14) | Descriptor: | Dwarf 88 esterase | Authors: | Zhou, X.E, Zhao, L.-H, Wu, Z.-S, Yi, W, Li, S, Li, Y, Xu, Y, Xu, T.-H, Liu, Y, Chen, R.-Z, Kovach, A, Kang, Y, Hou, L, He, Y, Zhang, C, Melcher, K, Xu, H.E. | Deposit date: | 2012-12-18 | Release date: | 2013-01-30 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Crystal structures of two phytohormone signal-transducing alpha / beta hydrolases: karrikin-signaling KAI2 and strigolactone-signaling DWARF14. Cell Res., 23, 2013
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4GO4
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![BU of 4go4 by Molmil](/molmil-images/mine/4go4) | Crystal structure of PnpE in complex with Nicotinamide adenine dinucleotide | Descriptor: | NICOTINAMIDE-ADENINE-DINUCLEOTIDE, Putative gamma-hydroxymuconic semialdehyde dehydrogenase | Authors: | Su, J, Zhang, C, Liu, S, Zhu, D, Gu, L. | Deposit date: | 2012-08-18 | Release date: | 2013-09-04 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (3.099 Å) | Cite: | Crystal structure of PnpE in complex with Nicotinamide adenine dinucleotide To be Published
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4GO3
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4IHA
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![BU of 4iha by Molmil](/molmil-images/mine/4iha) | Crystal structure of rice DWARF14 (D14) in complex with a GR24 hydrolysis intermediate | Descriptor: | (2R,3R)-2,4,4-trihydroxy-3-methylbutanal, Dwarf 88 esterase | Authors: | Zhou, X.E, Zhao, L.-H, Wu, Z.-S, Yi, W, Li, S, Li, Y, Xu, Y, Xu, T.-H, Liu, Y, Chen, R.-Z, Kovach, A, Kang, Y, Hou, L, He, Y, Zhang, C, Melcher, K, Xu, H.E. | Deposit date: | 2012-12-18 | Release date: | 2013-01-23 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Crystal structures of two phytohormone signal-transducing alpha / beta hydrolases: karrikin-signaling KAI2 and strigolactone-signaling DWARF14. Cell Res., 23, 2013
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4IH1
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![BU of 4ih1 by Molmil](/molmil-images/mine/4ih1) | Crystal structure of Karrikin Insensitive 2 (KAI2) from Arabidopsis thaliana | Descriptor: | Hydrolase, alpha/beta fold family protein | Authors: | Zhou, X.E, Zhao, L.-H, Wu, Z.-S, Yi, W, Li, S, Li, Y, Xu, Y, Xu, T.-H, Liu, Y, Chen, R.-Z, Kovach, A, Kang, Y, Hou, L, He, Y, Zhang, C, Melcher, K, Xu, H.E. | Deposit date: | 2012-12-18 | Release date: | 2013-01-30 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Crystal structures of two phytohormone signal-transducing alpha / beta hydrolases: karrikin-signaling KAI2 and strigolactone-signaling DWARF14. Cell Res., 23, 2013
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5Z9I
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![BU of 5z9i by Molmil](/molmil-images/mine/5z9i) | |
7M3G
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![BU of 7m3g by Molmil](/molmil-images/mine/7m3g) | Asymmetric Activation of the Calcium Sensing Receptor Homodimer | Descriptor: | 2-[4-[(3S)-3-[[(1R)-1-naphthalen-1-ylethyl]amino]pyrrolidin-1-yl]phenyl]ethanoic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Gao, Y, Robertson, M.J, Zhang, C, Meyerowitz, J.G, Panova, O, Skiniotis, G. | Deposit date: | 2021-03-18 | Release date: | 2021-06-30 | Last modified: | 2021-07-21 | Method: | ELECTRON MICROSCOPY (2.5 Å) | Cite: | Asymmetric activation of the calcium-sensing receptor homodimer. Nature, 595, 2021
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3E73
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![BU of 3e73 by Molmil](/molmil-images/mine/3e73) | Crystal Structure of Human LanCL1 complexed with GSH | Descriptor: | GLUTATHIONE, LanC-like protein 1, ZINC ION | Authors: | Zhang, W, Zhu, G, Li, X, Rao, Z, Zhang, C. | Deposit date: | 2008-08-17 | Release date: | 2009-06-30 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structure of human lanthionine synthetase C-like protein 1 and its interaction with Eps8 and glutathione Genes Dev., 23, 2009
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8T3S
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![BU of 8t3s by Molmil](/molmil-images/mine/8t3s) | Cryo-EM structure of the Butyrate bound FFA2-Gq complex | Descriptor: | CHOLESTEROL, Free fatty acid receptor 2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Zhang, X, Tikhonova, I, Milligan, G, Zhang, C. | Deposit date: | 2023-06-07 | Release date: | 2024-01-24 | Method: | ELECTRON MICROSCOPY (3.07 Å) | Cite: | Structural basis for the ligand recognition and signaling of free fatty acid receptors. Sci Adv, 10, 2024
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3E6U
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![BU of 3e6u by Molmil](/molmil-images/mine/3e6u) | Crystal structure of Human LanCL1 | Descriptor: | LanC-like protein 1, ZINC ION | Authors: | Zhang, W, Zhu, G, Li, X, Rao, Z, Zhang, C. | Deposit date: | 2008-08-16 | Release date: | 2009-06-23 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structure of human lanthionine synthetase C-like protein 1 and its interaction with Eps8 and glutathione Genes Dev., 23, 2009
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9BJK
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![BU of 9bjk by Molmil](/molmil-images/mine/9bjk) | Inactive mu opioid receptor bound to Nb6, naloxone and NAM | Descriptor: | Mu-type opioid receptor, Naloxone, Nalpha-[({(1M)-1-[5-(benzyloxy)pyridin-3-yl]naphthalen-2-yl}sulfanyl)acetyl]-3-methoxy-N,4-dimethyl-L-phenylalaninamide, ... | Authors: | O'Brien, E.S, Wang, H, Kaavya Krishna, K, Zhang, C, Kobilka, B.K. | Deposit date: | 2024-04-25 | Release date: | 2024-07-17 | Last modified: | 2024-08-14 | Method: | ELECTRON MICROSCOPY (3.26 Å) | Cite: | A mu-opioid receptor modulator that works cooperatively with naloxone. Nature, 631, 2024
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