8R0B
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![BU of 8r0b by Molmil](/molmil-images/mine/8r0b) | Cryo-EM structure of the cross-exon pre-B+ATP complex | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, 5'ss oligo, NHP2-like protein 1, ... | 著者 | Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R. | 登録日 | 2023-10-31 | 公開日 | 2024-05-22 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (4.4 Å) | 主引用文献 | Structural insights into the cross-exon to cross-intron spliceosome switch. Nature, 630, 2024
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8DMP
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8DMT
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![BU of 8dmt by Molmil](/molmil-images/mine/8dmt) | Crystal structure of macrodomain CG2909 from Drosophila melanogaster in complex with ADP-ribose | 分子名称: | RE54994p, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE | 著者 | Zhang, Z, Das, C. | 登録日 | 2022-07-08 | 公開日 | 2023-08-02 | 最終更新日 | 2024-07-24 | 実験手法 | X-RAY DIFFRACTION (2.28 Å) | 主引用文献 | Legionella metaeffector MavL reverses ubiquitin ADP-ribosylation via a conserved arginine-specific macrodomain. Nat Commun, 15, 2024
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6Y6I
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![BU of 6y6i by Molmil](/molmil-images/mine/6y6i) | lipopolysaccharide outer core galactosyltransferase WaaB and UDP complex | 分子名称: | Lipopolysaccharide 1,6-galactosyltransferase, URIDINE-5'-DIPHOSPHATE | 著者 | Zhang, Z.Y, Ashworth, G, Wang, Z.S, Zhu, X.F, Dong, C.J. | 登録日 | 2020-02-26 | 公開日 | 2021-03-31 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.92 Å) | 主引用文献 | Structural insights into the lipopolysaccharide outer core galactosyltransferase WaaB To Be Published
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6Y6G
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![BU of 6y6g by Molmil](/molmil-images/mine/6y6g) | lipopolysaccharide outer core galactosyltransferase WaaB apo form | 分子名称: | Lipopolysaccharide 1,6-galactosyltransferase | 著者 | Zhang, Z.Y, Ashworth, G, Wang, Z.S, Zhu, X.F, Dong, C.J. | 登録日 | 2020-02-26 | 公開日 | 2021-03-31 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (1.81 Å) | 主引用文献 | Structural insights into the lipopolysaccharide outer core galactosyltransferase WaaB To Be Published
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8QZS
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![BU of 8qzs by Molmil](/molmil-images/mine/8qzs) | Cryo-EM structure of the cross-exon B-like complex | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, Microfibrillar-associated protein 1, NHP2-like protein 1, ... | 著者 | Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R. | 登録日 | 2023-10-29 | 公開日 | 2024-05-22 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | Structural insights into the cross-exon to cross-intron spliceosome switch. Nature, 630, 2024
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8QXD
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![BU of 8qxd by Molmil](/molmil-images/mine/8qxd) | Cryo-EM structure of the cross-exon pre-B complex | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, NHP2-like protein 1, N-terminally processed, ... | 著者 | Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R. | 登録日 | 2023-10-24 | 公開日 | 2024-05-22 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (9.6 Å) | 主引用文献 | Structural insights into the cross-exon to cross-intron spliceosome switch. Nature, 630, 2024
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8QPA
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![BU of 8qpa by Molmil](/molmil-images/mine/8qpa) | Cryo-EM Structure of Pre-B+5'ssLNG Complex (core part) | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, 5'ss oligo, INOSITOL HEXAKISPHOSPHATE, ... | 著者 | Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R. | 登録日 | 2023-10-01 | 公開日 | 2024-05-22 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Structural insights into the cross-exon to cross-intron spliceosome switch. Nature, 630, 2024
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2BCC
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![BU of 2bcc by Molmil](/molmil-images/mine/2bcc) | STIGMATELLIN-BOUND CYTOCHROME BC1 COMPLEX FROM CHICKEN | 分子名称: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, FE2/S2 (INORGANIC) CLUSTER, PROTOPORPHYRIN IX CONTAINING FE, ... | 著者 | Zhang, Z, Huang, L, Shulmeister, V.M, Chi, Y.I, Kim, K.K, Hung, L.W, Crofts, A.R, Berry, E.A, Kim, S.H. | 登録日 | 1998-09-18 | 公開日 | 1999-08-02 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | 主引用文献 | Electron Transfer by Domain Movement in Cytochrome Bc1 Nature, 392, 1998
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8J8E
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![BU of 8j8e by Molmil](/molmil-images/mine/8j8e) | Human serum albumin-palladium(II) agent complex | 分子名称: | PALMITIC ACID, Serum albumin, ~{N},~{N}-dimethyl-7-phenyl-3-thia-1$l^{4},5,6$l^{4}-triaza-2$l^{3}-palladatricyclo[6.4.0.0^{2,6}]dodeca-1(12),4,6,8,10-pentaen-4-amine | 著者 | Zhang, Z.L, Zhang, J.Z. | 登録日 | 2023-05-01 | 公開日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structure of human serum albumin palladium(II) agent complex To Be Published
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8QOZ
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![BU of 8qoz by Molmil](/molmil-images/mine/8qoz) | Cryo-EM Structure of Pre-B+5'ss+ATPgammaS Complex (core part) | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, 5'ss RNA oligo, INOSITOL HEXAKISPHOSPHATE, ... | 著者 | Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R. | 登録日 | 2023-09-29 | 公開日 | 2024-05-22 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structural insights into the cross-exon to cross-intron spliceosome switch. Nature, 630, 2024
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8QPB
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![BU of 8qpb by Molmil](/molmil-images/mine/8qpb) | Cryo-EM Structure of Pre-B+ATP Complex (core part) | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, 5'ss oligo, INOSITOL HEXAKISPHOSPHATE, ... | 著者 | Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R. | 登録日 | 2023-10-01 | 公開日 | 2024-05-22 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Structural insights into the cross-exon to cross-intron spliceosome switch. Nature, 630, 2024
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8R08
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![BU of 8r08 by Molmil](/molmil-images/mine/8r08) | Cryo-EM structure of the cross-exon pre-B+AMPPNP complex | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, NHP2-like protein 1, N-terminally processed, ... | 著者 | Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R. | 登録日 | 2023-10-31 | 公開日 | 2024-05-22 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (6.1 Å) | 主引用文献 | Structural insights into the cross-exon to cross-intron spliceosome switch. Nature, 630, 2024
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8J5X
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![BU of 8j5x by Molmil](/molmil-images/mine/8j5x) | The crystal structure of TrkA(G595R) kinase in complex with N-(3-cyclopropyl-5-((4-methylpiperazin-1-yl)methyl)phenyl)-4^6-methyl-14-oxo-5-oxa-13-aza-1(3,6)-imidazo[1,2-b]pyridazina-4(1,3)-benzenacyclotetradecaphan-2-yne-4^5-carboxamide | 分子名称: | High affinity nerve growth factor receptor, N-(3-cyclopropyl-5-((4-methylpiperazin-1-yl)methyl)phenyl)-4^6-methyl-14-oxo-5-oxa-13-aza-1(3,6)-imidazo[1,2-b]pyridazina-4(1,3)-benzenacyclotetradecaphan-2-yne-4^5-carboxamide | 著者 | Zhang, Z.M, Wang, Y.J. | 登録日 | 2023-04-24 | 公開日 | 2023-09-20 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.09192252 Å) | 主引用文献 | Structure-Based Optimization of the Third Generation Type II Macrocycle TRK Inhibitors with Improved Activity against Solvent-Front, xDFG, and Gatekeeper Mutations. J.Med.Chem., 66, 2023
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8J5W
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![BU of 8j5w by Molmil](/molmil-images/mine/8j5w) | The crystal structure of TrkA(F589L) kinase in complex with N-(3-cyclopropyl-5-((4-methylpiperazin-1-yl)methyl)phenyl)-4^6-methyl-14-oxo-5-oxa-13-aza-1(3,6)-imidazo[1,2-b]pyridazina-4(1,3)-benzenacyclotetradecaphan-2-yne-4^5-carboxamide | 分子名称: | High affinity nerve growth factor receptor, N-(3-cyclopropyl-5-((4-methylpiperazin-1-yl)methyl)phenyl)-4^6-methyl-14-oxo-5-oxa-13-aza-1(3,6)-imidazo[1,2-b]pyridazina-4(1,3)-benzenacyclotetradecaphan-2-yne-4^5-carboxamide | 著者 | Zhang, Z.M, Wang, Y.J. | 登録日 | 2023-04-24 | 公開日 | 2023-09-20 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.28041458 Å) | 主引用文献 | Structure-Based Optimization of the Third Generation Type II Macrocycle TRK Inhibitors with Improved Activity against Solvent-Front, xDFG, and Gatekeeper Mutations. J.Med.Chem., 66, 2023
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8J61
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![BU of 8j61 by Molmil](/molmil-images/mine/8j61) | The crystal structure of TrkA kinase in complex with 4^6-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-14-oxo-5-oxa-13-aza-1(3,6)-imidazo[1,2-b]pyridazina-4(1,3)-benzenacyclotetradecaphan-2-yne-4^5-carboxamide | 分子名称: | 4^6-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-14-oxo-5-oxa-13-aza-1(3,6)-imidazo[1,2-b]pyridazina-4(1,3)-benzenacyclotetradecaphan-2-yne-4^5-carboxamide, High affinity nerve growth factor receptor | 著者 | Zhang, Z.M, Wang, Y.J. | 登録日 | 2023-04-24 | 公開日 | 2023-09-20 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3.05065274 Å) | 主引用文献 | Structure-Based Optimization of the Third Generation Type II Macrocycle TRK Inhibitors with Improved Activity against Solvent-Front, xDFG, and Gatekeeper Mutations. J.Med.Chem., 66, 2023
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8J63
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![BU of 8j63 by Molmil](/molmil-images/mine/8j63) | The crystal structure of TrkA kinase in complex with 4^6-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-11-oxo-5-oxa-10,14-diaza-1(3,6)-imidazo[1,2-b]pyridazina-4(1,3)-benzenacyclotetradecaphan-2-yne-4^5-carboxamide | 分子名称: | 4^6-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-11-oxo-5-oxa-10,14-diaza-1(3,6)-imidazo[1,2-b]pyridazina-4(1,3)-benzenacyclotetradecaphan-2-yne-4^5-carboxamide, High affinity nerve growth factor receptor | 著者 | Zhang, Z.M, Wang, Y.J. | 登録日 | 2023-04-24 | 公開日 | 2023-09-20 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3.0005 Å) | 主引用文献 | Structure-Based Optimization of the Third Generation Type II Macrocycle TRK Inhibitors with Improved Activity against Solvent-Front, xDFG, and Gatekeeper Mutations. J.Med.Chem., 66, 2023
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8T4V
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![BU of 8t4v by Molmil](/molmil-images/mine/8t4v) | Crystal structure of compound 1 bound to K-Ras(G12D) | 分子名称: | 4-{(1R,5S)-3-[(7P)-7-(8-ethynylnaphthalen-1-yl)-8-fluoro-2-{[(4s,7as)-tetrahydro-1H-pyrrolizin-7a(5H)-yl]methoxy}pyrido[4,3-d]pyrimidin-4-yl]-3,8-diazabicyclo[3.2.1]octan-8-yl}-4-oxobutanoic acid, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ... | 著者 | Zhang, Z, Zheng, Q, Guiley, K.Z, Shokat, K.M. | 登録日 | 2023-06-10 | 公開日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.47 Å) | 主引用文献 | Strain-release alkylation of Asp12 enables mutant selective targeting of K-Ras-G12D. Nat.Chem.Biol., 2024
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8INP
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![BU of 8inp by Molmil](/molmil-images/mine/8inp) | A reversible glycosyltransferase of tectorigenin - Bc7OUGT | 分子名称: | Bc7OUGT, URIDINE-5'-DIPHOSPHATE, beta-D-glucopyranose | 著者 | Zhang, Z.Y, Lu, L, Guan, Z.F, Cheng, W.J. | 登録日 | 2023-03-10 | 公開日 | 2023-08-23 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.12 Å) | 主引用文献 | Functional characterization and structural basis of a reversible glycosyltransferase involves in plant chemical defence. Plant Biotechnol J, 21, 2023
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8ITA
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![BU of 8ita by Molmil](/molmil-images/mine/8ita) | A reversible glycosyltransferase of tectorigenin - Bc7OUGT complexed with UDP and tectorigenin | 分子名称: | 3-(4-hydroxyphenyl)-6-methoxy-5,7-bis(oxidanyl)chromen-4-one, Bc7OUGT, URIDINE-5'-DIPHOSPHATE | 著者 | Zhang, Z.Y, Lu, L, Guan, Z.F, Cheng, W.J. | 登録日 | 2023-03-22 | 公開日 | 2023-08-23 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Functional characterization and structural basis of a reversible glycosyltransferase involves in plant chemical defence. Plant Biotechnol J, 21, 2023
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8Q7N
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![BU of 8q7n by Molmil](/molmil-images/mine/8q7n) | cryo-EM structure of the human spliceosomal B complex protomer (tri-snRNP core region) | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, MINX pre-mRNA, Microfibrillar-associated protein 1, ... | 著者 | Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Urlaub, H, Stark, H, Luehrmann, R. | 登録日 | 2023-08-16 | 公開日 | 2024-01-24 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | New insights into the functions of B complex proteins revealed by cryo-EM of dimerized spliceosomes To Be Published
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7OQE
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![BU of 7oqe by Molmil](/molmil-images/mine/7oqe) | Saccharomyces cerevisiae spliceosomal pre-A complex (delta BS-A ACT1) | 分子名称: | 56 kDa U1 small nuclear ribonucleoprotein component, ACT1 pre-mRNA (delta BS-A), Cold sensitive U2 snRNA suppressor 1, ... | 著者 | Zhang, Z, Rigo, N, Dybkov, O, Fourmann, J, Will, C.L, Kumar, V, Urlaub, H, Stark, H, Luehrmann, R. | 登録日 | 2021-06-03 | 公開日 | 2021-08-11 | 最終更新日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (5.9 Å) | 主引用文献 | Structural insights into how Prp5 proofreads the pre-mRNA branch site. Nature, 596, 2021
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8QPK
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![BU of 8qpk by Molmil](/molmil-images/mine/8qpk) | Cryo-EM Structure of Pre-B+5'ss Complex (core part) | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, 5'ss oligo, INOSITOL HEXAKISPHOSPHATE, ... | 著者 | Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R. | 登録日 | 2023-10-02 | 公開日 | 2024-05-22 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | 主引用文献 | Structural insights into the cross-exon to cross-intron spliceosome switch. Nature, 630, 2024
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8UVK
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![BU of 8uvk by Molmil](/molmil-images/mine/8uvk) | CosR DNA bound form II | 分子名称: | DI(HYDROXYETHYL)ETHER, DNA (5'-D(*AP*AP*TP*TP*AP*AP*GP*AP*TP*AP*TP*TP*AP*TP*TP*AP*AP*CP*CP*AP*A)-3'), DNA (5'-D(*TP*TP*GP*GP*TP*TP*AP*AP*TP*AP*AP*TP*AP*TP*CP*TP*TP*AP*AP*TP*T)-3'), ... | 著者 | Zhang, Z. | 登録日 | 2023-11-03 | 公開日 | 2024-01-31 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.21 Å) | 主引用文献 | Structural basis of DNA recognition of the Campylobacter jejuni CosR regulator. Mbio, 15, 2024
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8UVX
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![BU of 8uvx by Molmil](/molmil-images/mine/8uvx) | CosR DNA bound form I | 分子名称: | DNA (5'-D(*AP*TP*AP*TP*CP*TP*TP*AP*AP*TP*TP*TP*TP*GP*GP*TP*TP*AP*AP*TP*A)-3'), DNA (5'-D(*TP*AP*TP*TP*AP*AP*CP*CP*AP*AP*AP*AP*TP*TP*AP*AP*GP*AP*TP*AP*T)-3'), DNA-binding response regulator | 著者 | Zhang, Z. | 登録日 | 2023-11-05 | 公開日 | 2024-01-31 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Structural basis of DNA recognition of the Campylobacter jejuni CosR regulator. Mbio, 15, 2024
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