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PDB: 48 results

4PDR
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BU of 4pdr by Molmil
Crystal Structure of a K+ selective NaK mutant in Barium and Sodium
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, BARIUM ION, Potassium channel protein, ...
Authors:Lam, Y, Zeng, W, Sauer, D.B, Jiang, Y.
Deposit date:2014-04-21
Release date:2014-07-09
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:High Resolution Structural Views of Rubidium, Cesium and Barium Binding within a Potassium Selective Channel Filter
To Be Published
4QE7
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BU of 4qe7 by Molmil
Open MthK pore structure soaked in 10 mM Ba2+/100 mM Na+
Descriptor: BARIUM ION, Calcium-gated potassium channel MthK
Authors:Guo, R, Zeng, W, Cui, H, Chen, L, Ye, S.
Deposit date:2014-05-15
Release date:2014-07-09
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Ionic interactions of Ba2+ blockades in the MthK K+ channel
J.Gen.Physiol., 144, 2014
4PDL
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BU of 4pdl by Molmil
Structure of K+ selective NaK mutant in caesium
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, CESIUM ION, HEXANE, ...
Authors:Lam, Y, Zeng, W, Sauer, D.B, Jiang, Y.
Deposit date:2014-04-19
Release date:2014-07-09
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:High Resolution Structural Views of Rubidium, Cesium and Barium Binding within a Potassium Selective Channel Filter
To Be Published
5HAW
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BU of 5haw by Molmil
structures of the NO factor SlmA bound to DNA and the cytoskeletal cell division protein FtsZ
Descriptor: DNA (5'-D(*GP*TP*GP*AP*GP*TP*AP*CP*TP*CP*AP*C)-3'), FtsZ CTT, Nucleoid occlusion factor SlmA
Authors:Schumacher, M.A, Zeng, W.
Deposit date:2015-12-31
Release date:2016-04-13
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Structures of the nucleoid occlusion protein SlmA bound to DNA and the C-terminal domain of the cytoskeletal protein FtsZ.
Proc.Natl.Acad.Sci.USA, 113, 2016
4QE9
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BU of 4qe9 by Molmil
Open MthK pore structure soaked in 10 mM Ba2+/100 mM K+
Descriptor: Calcium-gated potassium channel MthK, POTASSIUM ION
Authors:Guo, R, Zeng, W, Cui, H, Chen, L, Ye, S.
Deposit date:2014-05-15
Release date:2014-07-09
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Ionic interactions of Ba2+ blockades in the MthK K+ channel
J.Gen.Physiol., 144, 2014
3OUS
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BU of 3ous by Molmil
MthK channel pore T59A mutant
Descriptor: Calcium-gated potassium channel mthK, POTASSIUM ION
Authors:Derebe, M.G, Sauer, D.B, Zeng, W, Alam, A, Shi, N, Jiang, Y.
Deposit date:2010-09-15
Release date:2011-01-12
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Tuning the ion selectivity of tetrameric cation channels by changing the number of ion binding sites.
Proc.Natl.Acad.Sci.USA, 108, 2011
3R65
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BU of 3r65 by Molmil
MthK channel pore E92Q mutant
Descriptor: Calcium-gated potassium channel mthK, POTASSIUM ION
Authors:Shi, N, Zeng, W, Ye, S, Li, Y, Jiang, Y.
Deposit date:2011-03-21
Release date:2012-02-01
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crucial points within the pore as determinants of K+ channel conductance and gating
J.Mol.Biol., 411, 2011
4GVL
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BU of 4gvl by Molmil
Crystal Structure of the GsuK RCK domain
Descriptor: ADENOSINE MONOPHOSPHATE, CALCIUM ION, TrkA domain protein, ...
Authors:Kong, C, Zeng, W, Ye, S, Chen, L, Sauer, D.B, Lam, Y, Derebe, M.G, Jiang, Y.
Deposit date:2012-08-30
Release date:2012-12-26
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Distinct gating mechanisms revealed by the structures of a multi-ligand gated K(+) channel.
elife, 1, 2012
3T2M
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BU of 3t2m by Molmil
Crystal Structure of NaK Channel N68D Mutant
Descriptor: POTASSIUM ION, Potassium channel protein
Authors:Sauer, D.B, Zeng, W, Raghunathan, S, Jiang, Y.
Deposit date:2011-07-22
Release date:2011-10-05
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.953 Å)
Cite:Protein interactions central to stabilizing the K+ channel selectivity filter in a four-sited configuration for selective K+ permeation.
Proc.Natl.Acad.Sci.USA, 108, 2011
3T1C
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BU of 3t1c by Molmil
Crystal Structure of NaK Channel D66Y Mutant
Descriptor: POTASSIUM ION, Potassium channel protein
Authors:Sauer, D.B, Zeng, W, Raghunathan, S, Jiang, Y.
Deposit date:2011-07-21
Release date:2011-10-05
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.802 Å)
Cite:Protein interactions central to stabilizing the K+ channel selectivity filter in a four-sited configuration for selective K+ permeation.
Proc.Natl.Acad.Sci.USA, 108, 2011
3T4D
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BU of 3t4d by Molmil
Crystal Structure of NaK2K Channel Y55F Mutant
Descriptor: POTASSIUM ION, Potassium channel protein
Authors:Sauer, D.B, Zeng, W, Raghunathan, S, Jiang, Y.
Deposit date:2011-07-25
Release date:2011-10-05
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Protein interactions central to stabilizing the K+ channel selectivity filter in a four-sited configuration for selective K+ permeation.
Proc.Natl.Acad.Sci.USA, 108, 2011
6NQ0
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BU of 6nq0 by Molmil
Cryo-EM structure of human TPC2 channel in the ligand-bound open state
Descriptor: (2R)-3-{[(S)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,4,6-trihydroxy-3,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctanoate, Two pore calcium channel protein 2
Authors:She, J, Zeng, W, Guo, J, Chen, Q, Bai, X, Jiang, Y.
Deposit date:2019-01-18
Release date:2019-03-27
Last modified:2024-11-13
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Structural mechanisms of phospholipid activation of the human TPC2 channel.
Elife, 8, 2019
6NQ1
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BU of 6nq1 by Molmil
Cryo-EM structure of human TPC2 channel in the apo state
Descriptor: Two pore calcium channel protein 2
Authors:She, J, Zeng, W, Guo, J, Chen, Q, Bai, X, Jiang, Y.
Deposit date:2019-01-18
Release date:2019-03-27
Last modified:2024-11-06
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structural mechanisms of phospholipid activation of the human TPC2 channel.
Elife, 8, 2019
6NQ2
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BU of 6nq2 by Molmil
Cryo-EM structure of human TPC2 channel in the ligand-bound closed state
Descriptor: (2R)-3-{[(S)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,4,6-trihydroxy-3,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctanoate, Two pore calcium channel protein 2
Authors:She, J, Zeng, W, Guo, J, Chen, Q, Bai, X, Jiang, Y.
Deposit date:2019-01-18
Release date:2019-03-27
Last modified:2024-11-20
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structural mechanisms of phospholipid activation of the human TPC2 channel.
Elife, 8, 2019
8FYF
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BU of 8fyf by Molmil
Human TMEM175-LAMP1 transmembrane domain only complex
Descriptor: Endosomal/lysosomal potassium channel TMEM175, Lysosome-associated membrane glycoprotein 1
Authors:Zhang, J.Y, Zeng, W.Z, Han, Y, Jiang, Y.X.
Deposit date:2023-01-26
Release date:2023-06-28
Last modified:2024-06-19
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Lysosomal LAMP proteins regulate lysosomal pH by direct inhibition of the TMEM175 channel.
Mol.Cell, 83, 2023
8FY5
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BU of 8fy5 by Molmil
Human TMEM175-LAMP1 full-length complex
Descriptor: Endosomal/lysosomal potassium channel TMEM175, Lysosome-associated membrane glycoprotein 1
Authors:Zhang, J.Y, Zeng, W.Z, Han, Y, Jiang, Y.X.
Deposit date:2023-01-25
Release date:2023-06-28
Last modified:2024-06-19
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Lysosomal LAMP proteins regulate lysosomal pH by direct inhibition of the TMEM175 channel.
Mol.Cell, 83, 2023
7VOA
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BU of 7voa by Molmil
Crystal structure of SARS-CoV-2 RBD in complex with aRBD5
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, alpaca nanobody
Authors:Ma, H, Zeng, W.H, Jin, T.C.
Deposit date:2021-10-13
Release date:2022-08-10
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Hetero-bivalent nanobodies provide broad-spectrum protection against SARS-CoV-2 variants of concern including Omicron.
Cell Res., 32, 2022
7X4I
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BU of 7x4i by Molmil
Crystal structure of nanobody aSA3 in complex with dimer SARS-CoV-1 RBD
Descriptor: Spike glycoprotein, nanobody aSA3
Authors:Ma, H, Zeng, W.H, Jin, T.C.
Deposit date:2022-03-02
Release date:2023-01-11
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (3.38 Å)
Cite:A bispecific nanobody dimer broadly neutralizes SARS-CoV-1 & 2 variants of concern and offers substantial protection against Omicron via low-dose intranasal administration.
Cell Discov, 8, 2022
7VVE
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BU of 7vve by Molmil
Complex structure of a leaf-branch compost cutinase variant in complex with mono(2-hydroxyethyl) terephthalic acid
Descriptor: 2-(2-METHOXYETHOXY)ETHANOL, 4-(2-hydroxyethyloxycarbonyl)benzoic acid, CALCIUM ION, ...
Authors:Niu, D, Zeng, W, Huang, J.W, Chen, C.C, Liu, W.D, Guo, R.T.
Deposit date:2021-11-05
Release date:2022-03-09
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Substrate-Binding Mode of a Thermophilic PET Hydrolase and Engineering the Enzyme to Enhance the Hydrolytic Efficacy.
Acs Catalysis, 12, 2022
7W44
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BU of 7w44 by Molmil
Complex structure of a leaf-branch compost cutinase variant LCC ICCG_RIP
Descriptor: 1,2-ETHANEDIOL, IMIDAZOLE, Leaf-branch compost cutinase
Authors:Niu, D, Zeng, W, Huang, J.W, Chen, C.C, Liu, W.D, Guo, R.T.
Deposit date:2021-11-26
Release date:2022-03-09
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Substrate-Binding Mode of a Thermophilic PET Hydrolase and Engineering the Enzyme to Enhance the Hydrolytic Efficacy.
Acs Catalysis, 12, 2022
7W1N
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BU of 7w1n by Molmil
Complex structure of a leaf-branch compost cutinase variant LCC ICCG_KRP
Descriptor: 1,2-ETHANEDIOL, BICINE, Leaf-branch compost cutinase
Authors:Niu, D, Zeng, W, Huang, J.W, Chen, C.C, Liu, W.D, Guo, R.T.
Deposit date:2021-11-19
Release date:2022-03-09
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Substrate-Binding Mode of a Thermophilic PET Hydrolase and Engineering the Enzyme to Enhance the Hydrolytic Efficacy.
Acs Catalysis, 12, 2022
7VVC
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BU of 7vvc by Molmil
Crystal structure of inactive mutant of leaf-branch compost cutinase variant
Descriptor: ACETATE ION, ACETIC ACID, CALCIUM ION, ...
Authors:Niu, D, Zeng, W, Huang, J.W, Chen, C.C, Liu, W.D, Guo, R.T.
Deposit date:2021-11-05
Release date:2022-03-09
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Substrate-Binding Mode of a Thermophilic PET Hydrolase and Engineering the Enzyme to Enhance the Hydrolytic Efficacy.
Acs Catalysis, 12, 2022
7W45
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BU of 7w45 by Molmil
Complex structure of a leaf-branch compost cutinase variant LCC ICCG_KIP
Descriptor: CALCIUM ION, Leaf-branch compost cutinase, SODIUM ION
Authors:Niu, D, Zeng, W, Huang, J.W, Chen, C.C, Liu, W.D, Guo, R.T.
Deposit date:2021-11-26
Release date:2022-03-09
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Substrate-Binding Mode of a Thermophilic PET Hydrolase and Engineering the Enzyme to Enhance the Hydrolytic Efficacy.
Acs Catalysis, 12, 2022
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