7X4I

Crystal structure of nanobody aSA3 in complex with dimer SARS-CoV-1 RBD

Summary for 7X4I

Entry DOI	10.2210/pdb7x4i/pdb
Descriptor	Spike glycoprotein, nanobody aSA3 (2 entities in total)
Functional Keywords	nanobody, sars-cov-1, rbd, antiviral protein
Biological source	Severe acute respiratory syndrome coronavirus More
Total number of polymer chains	8
Total formula weight	145554.56
Authors	Ma, H.,Zeng, W.H.,Jin, T.C. (deposition date: 2022-03-02, release date: 2023-01-11, Last modification date: 2023-11-29)
Primary citation	Ma, H.,Zhang, X.,Zeng, W.,Zhou, J.,Chi, X.,Chen, S.,Zheng, P.,Wang, M.,Wu, Y.,Zhao, D.,Gong, F.,Lin, H.,Sun, H.,Yu, C.,Shi, Z.,Hu, X.,Zhang, H.,Jin, T.,Chiu, S. A bispecific nanobody dimer broadly neutralizes SARS-CoV-1 & 2 variants of concern and offers substantial protection against Omicron via low-dose intranasal administration. Cell Discov, 8:132-132, 2022 Cited by PubMed: 36494344 DOI: 10.1038/s41421-022-00497-w PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.38 Å)

Structure validation