5X2K
 
 | |
5XGM
 | | Crystal structure of EGFR 696-1022 T790M in complex with Go6976 | | 分子名称: | 12-(2-Cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole, Epidermal growth factor receptor | | 著者 | Kong, L.L, Yun, C.H. | | 登録日 | 2017-04-14 | | 公開日 | 2017-10-11 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.952 Å) | | 主引用文献 | Structural pharmacological studies on EGFR T790M/C797S.
Biochem. Biophys. Res. Commun., 488, 2017
|
|
5XDK
 | | Crystal structure of EGFR 696-1022 T790M in complex with CO-1686 | | 分子名称: | Epidermal growth factor receptor, N-[3-[[2-[[4-(4-ethanoylpiperazin-1-yl)-2-methoxy-phenyl]amino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]phenyl]prop-2-enamide | | 著者 | Yan, X.E, Yun, C.H. | | 登録日 | 2017-03-28 | | 公開日 | 2017-12-13 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (2.346 Å) | | 主引用文献 | Structural basis of mutant-selectivity and drug-resistance related to CO-1686.
Oncotarget, 8, 2017
|
|
4RZK
 | | Crystal structure of Sulfolobus solfataricus Hsp20.1 ACD | | 分子名称: | Small heat shock protein hsp20 family | | 著者 | Liang, L, Yun, C.H. | | 登録日 | 2014-12-22 | | 公開日 | 2015-12-23 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.677 Å) | | 主引用文献 | Crystal structure and function of an unusual dimeric Hsp20.1 provide insight into the thermal protection mechanism of small heat shock proteins.
Biochem.Biophys.Res.Commun., 2015
|
|
4YL9
 | | Crystal Structure of wild-type of hsp14.1 from Sulfolobus solfatataricus P2 | | 分子名称: | 1,2-ETHANEDIOL, CALCIUM ION, Heat shock protein Hsp20 | | 著者 | Liu, L, Chen, J.Y, Yun, C.H. | | 登録日 | 2015-03-05 | | 公開日 | 2015-11-04 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.353 Å) | | 主引用文献 | Active-State Structures of a Small Heat-Shock Protein Revealed a Molecular Switch for Chaperone Function
Structure, 23, 2015
|
|
4YLB
 | |
8H75
 | | FGFR2 in complex with YJ001 | | 分子名称: | CHLORIDE ION, Fibroblast growth factor receptor 2, Tinengotinib | | 著者 | Yan, X.E, Yun, C.H. | | 登録日 | 2022-10-19 | | 公開日 | 2023-10-25 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (3.75 Å) | | 主引用文献 | FGFR2 in complex with YJ001
To Be Published
|
|
4ZSE
 | |
4YLC
 | |
4Z21
 | | Crystal structure of ARNO Sec7 | | 分子名称: | 1,2-ETHANEDIOL, Cytohesin-2 | | 著者 | Zhu, S.J, Yun, C.H. | | 登録日 | 2015-03-28 | | 公開日 | 2016-05-04 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | Lack of evidence that CYTH2/ARNO functions as an intracellular EGFR activator
To Be Published
|
|
5DH3
 | | Crystal structure of MST2 in complex with XMU-MP-1 | | 分子名称: | 4-[(5,10-dimethyl-6-oxo-6,10-dihydro-5H-pyrimido[5,4-b]thieno[3,2-e][1,4]diazepin-2-yl)amino]benzenesulfonamide, CHLORIDE ION, SULFATE ION, ... | | 著者 | Kong, L.L, Yun, C.H. | | 登録日 | 2015-08-29 | | 公開日 | 2016-08-31 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (2.468 Å) | | 主引用文献 | Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration
Sci Transl Med, 8, 2016
|
|
6IEG
 | | Crystal structure of human MTR4 | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Exosome RNA helicase MTR4, MAGNESIUM ION | | 著者 | Chen, J.Y, Yun, C.H. | | 登録日 | 2018-09-14 | | 公開日 | 2019-04-03 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (3.55 Å) | | 主引用文献 | NRDE2 negatively regulates exosome functions by inhibiting MTR4 recruitment and exosome interaction.
Genes Dev., 33, 2019
|
|
6IEH
 | | Crystal structures of the hMTR4-NRDE2 complex | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, Exosome RNA helicase MTR4, ... | | 著者 | Chen, J.Y, Yun, C.H. | | 登録日 | 2018-09-14 | | 公開日 | 2019-04-03 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.892 Å) | | 主引用文献 | NRDE2 negatively regulates exosome functions by inhibiting MTR4 recruitment and exosome interaction.
Genes Dev., 33, 2019
|
|
4K11
 | | The structure of 1NA in complex with Src T338G | | 分子名称: | 1-tert-butyl-3-(naphthalen-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Proto-oncogene tyrosine-protein kinase Src | | 著者 | Eck, M.J, Yun, C.H. | | 登録日 | 2013-04-04 | | 公開日 | 2014-04-09 | | 最終更新日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | The structure of 1NA in complex with Src T338G
To be Published
|
|
5GNK
 | | Crystal structure of EGFR 696-988 T790M in complex with LXX-6-34 | | 分子名称: | 1,2-ETHANEDIOL, 1-[(3R)-3-[4-azanyl-3-[3-chloranyl-4-[(1-methylimidazol-2-yl)methoxy]phenyl]pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-one, CHLORIDE ION, ... | | 著者 | Yan, X.E, Yun, C.H. | | 登録日 | 2016-07-21 | | 公開日 | 2017-04-05 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (1.796 Å) | | 主引用文献 | Discovery of (R)-1-(3-(4-Amino-3-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one (CHMFL-EGFR-202) as a Novel Irreversible EGFR Mutant Kinase Inhibitor with a Distinct Binding Mode.
J. Med. Chem., 60, 2017
|
|
5GTY
 | | Crystal structure of EGFR 696-1022 T790M in complex with LXX-6-26 | | 分子名称: | 1,2-ETHANEDIOL, 1-[(3R)-3-[4-azanyl-3-[3-chloranyl-4-[(6-methylpyridin-2-yl)methoxy]phenyl]pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-one, Epidermal growth factor receptor | | 著者 | Yan, X.E, Yun, C.H. | | 登録日 | 2016-08-23 | | 公開日 | 2017-09-06 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (3.14 Å) | | 主引用文献 | Discovery and characterization of a novel irreversible EGFR mutants selective and potent kinase inhibitor CHMFL-EGFR-26 with a distinct binding mode.
Oncotarget, 8, 2017
|
|
5GTZ
 | |
5HH1
 | |
5HU9
 | | Crystal structure of ABL1 in complex with CHMFL-074 | | 分子名称: | 1,2-ETHANEDIOL, 4-[(4-methylpiperazin-1-yl)methyl]-N-(4-methyl-3-{[1-(pyridin-3-ylcarbonyl)piperidin-4-yl]oxy}phenyl)-3-(trifluoromethyl)benzamide, CHLORIDE ION, ... | | 著者 | Kong, L.L, Yun, C.H. | | 登録日 | 2016-01-27 | | 公開日 | 2016-07-13 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.529 Å) | | 主引用文献 | Discovery and characterization of a novel potent type II native and mutant BCR-ABL inhibitor (CHMFL-074) for Chronic Myeloid Leukemia (CML)
Oncotarget, 7, 2016
|
|
5HH0
 | |
5HGZ
 | | Crystal structure of human Naa60 in complex with acetyl-CoA | | 分子名称: | ACETYL COENZYME *A, MALONIC ACID, N-alpha-acetyltransferase 60 | | 著者 | Chen, J.Y, Liu, L, Yun, C.H. | | 登録日 | 2016-01-09 | | 公開日 | 2016-09-14 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (1.383 Å) | | 主引用文献 | Structure and function of human Naa60 (NatF), a Golgi-localized bi-functional acetyltransferase
Sci Rep, 6, 2016
|
|
5GWN
 | |
5GRN
 | | Crystal structure of PDGFRA in Complex with WQ-C-159 | | 分子名称: | CHLORIDE ION, N-[2-(dimethylamino)ethyl]-N-[[4-[[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]carbamoyl]phenyl]methyl]pyridine-3-carboxamide, Platelet-derived growth factor receptor alpha | | 著者 | Yan, X.E, Yun, C.H. | | 登録日 | 2016-08-11 | | 公開日 | 2017-08-16 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.77 Å) | | 主引用文献 | Crystal Structure of PDGFRA in Complex with WQ-C-159
To Be Published
|
|
5GMP
 | | Crystal structure of EGFR 696-1022 T790M in complex with XTF-262 | | 分子名称: | Epidermal growth factor receptor, N-[3-[2-[[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino]-5-methyl-7-oxidanylidene-pyrido[2,3-d]pyrimidin-8-yl]phenyl]prop-2-enamide | | 著者 | Yan, X.E, Yun, C.H. | | 登録日 | 2016-07-14 | | 公開日 | 2017-06-28 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.797 Å) | | 主引用文献 | A structure-guided optimization of pyrido[2,3-d]pyrimidin-7-ones as selective inhibitors of EGFR(L858R/T790M) mutant with improved pharmacokinetic properties.
Eur J Med Chem, 126, 2017
|
|
6JOL
 | |
