5HU9
Crystal structure of ABL1 in complex with CHMFL-074
Summary for 5HU9
Entry DOI | 10.2210/pdb5hu9/pdb |
Descriptor | Tyrosine-protein kinase ABL1, 4-[(4-methylpiperazin-1-yl)methyl]-N-(4-methyl-3-{[1-(pyridin-3-ylcarbonyl)piperidin-4-yl]oxy}phenyl)-3-(trifluoromethyl)benzamide, 1,2-ETHANEDIOL, ... (5 entities in total) |
Functional Keywords | abl, bcr-abl, chmfl-074, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm, cytoskeleton. Isoform IB: Nucleus membrane; Lipid-anchor: P00519 |
Total number of polymer chains | 1 |
Total formula weight | 33954.19 |
Authors | Kong, L.L.,Yun, C.H. (deposition date: 2016-01-27, release date: 2016-07-13, Last modification date: 2023-11-08) |
Primary citation | Liu, F.,Wang, B.,Wang, Q.,Qi, Z.,Chen, C.,Kong, L.L.,Chen, J.Y.,Liu, X.,Wang, A.,Hu, C.,Wang, W.,Wang, H.,Wu, F.,Ruan, Y.,Qi, S.,Liu, J.,Zou, F.,Hu, Z.,Wang, W.,Wang, L.,Zhang, S.,Yun, C.H.,Zhai, Z.,Liu, J.,Liu, Q. Discovery and characterization of a novel potent type II native and mutant BCR-ABL inhibitor (CHMFL-074) for Chronic Myeloid Leukemia (CML) Oncotarget, 7:45562-45574, 2016 Cited by PubMed: 27322145DOI: 10.18632/oncotarget.10037 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.529 Å) |
Structure validation
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