4DW2
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![BU of 4dw2 by Molmil](/molmil-images/mine/4dw2) | The crystal structure of uPA in complex with the Fab fragment of mAb-112 | 分子名称: | Fab fragment of pro-uPA antibody mAb-112, SULFATE ION, Urokinase-type plasminogen activator | 著者 | Jiang, L, Botkjaer, K.A, Andersen, L.M, Yuan, C, Andreasen, P.A, Huang, M. | 登録日 | 2012-02-24 | 公開日 | 2013-01-16 | 実験手法 | X-RAY DIFFRACTION (2.97 Å) | 主引用文献 | Rezymogenation of active urokinase induced by an inhibitory antibody. Biochem.J., 449, 2013
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6XVD
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![BU of 6xvd by Molmil](/molmil-images/mine/6xvd) | Crystal structure of complex of urokinase and a upain-1 variant(W3F) in pH7.4 condition | 分子名称: | Urokinase-type plasminogen activator, upain-1-W3F | 著者 | Xue, G.P, Xie, X, Zhou, Y, Yuan, C, Huang, M.D, Jiang, L.G. | 登録日 | 2020-01-21 | 公開日 | 2020-02-19 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Insight to the residue in P2 position prevents the peptide inhibitor from being hydrolyzed by serine proteases. Biosci.Biotechnol.Biochem., 84, 2020
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4DVA
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![BU of 4dva by Molmil](/molmil-images/mine/4dva) | The crystal structure of human urokinase-type plasminogen activator catalytic domain | 分子名称: | HEXAETHYLENE GLYCOL, SULFATE ION, Urokinase-type plasminogen activator | 著者 | Jiang, L, Botkjaer, K.A, Andersen, L.M, Yuan, C, Andreasen, P.A, Huang, M. | 登録日 | 2012-02-23 | 公開日 | 2013-01-16 | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | 主引用文献 | Rezymogenation of active urokinase induced by an inhibitory antibody Biochem.J., 449, 2013
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1LXC
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![BU of 1lxc by Molmil](/molmil-images/mine/1lxc) | Crystal Structure of E. Coli Enoyl Reductase-NAD+ with a Bound Acrylamide Inhibitor | 分子名称: | 3-(6-AMINOPYRIDIN-3-YL)-N-METHYL-N-[(1-METHYL-1H-INDOL-2-YL)METHYL]ACRYLAMIDE, ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE | 著者 | Miller, W.H, Seefeld, M.A, Newlander, K.A, Uzinskas, I.N, Burgess, W.J, Heerding, D.A, Yuan, C.C.K, Head, M.S, Payne, D.J, Rittenhouse, S.F, Moore, T.D, Pearson, S.C, Dewolf, V, Berry, W.E, Keller, P.M, Polizzi, B.J, Qiu, X, Janson, C.A, Huffman, W.F. | 登録日 | 2002-06-05 | 公開日 | 2002-09-04 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Discovery of aminopyridine-based inhibitors of bacterial enoyl-ACP reductase (FabI). J.Med.Chem., 45, 2002
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4DVB
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![BU of 4dvb by Molmil](/molmil-images/mine/4dvb) | The crystal structure of the Fab fragment of pro-uPA antibody mAb-112 | 分子名称: | Fab fragment of pro-uPA antibody mAb-112, SULFATE ION, TETRAETHYLENE GLYCOL | 著者 | Jiang, L, Botkjaer, K.A, Andersen, L.M, Yuan, C, Andreasen, P.A, Huang, M. | 登録日 | 2012-02-23 | 公開日 | 2013-01-16 | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | 主引用文献 | Rezymogenation of active urokinase induced by an inhibitory antibody. Biochem.J., 449, 2013
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6BV7
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![BU of 6bv7 by Molmil](/molmil-images/mine/6bv7) | |
3G7N
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![BU of 3g7n by Molmil](/molmil-images/mine/3g7n) | Crystal Structure of a Triacylglycerol Lipase from Penicillium Expansum at 1.3 | 分子名称: | DI(HYDROXYETHYL)ETHER, Lipase, PENTAETHYLENE GLYCOL, ... | 著者 | Bian, C.B, Yuan, C, Chen, L.Q, Edward, J.M, Lin, L, Jiang, L.G, Huang, Z.X, Huang, M.D. | 登録日 | 2009-02-10 | 公開日 | 2010-02-23 | 最終更新日 | 2017-11-01 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Crystal structure of a triacylglycerol lipase from Penicillium expansum at 1.3 A determined by sulfur SAD Proteins, 78, 2010
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2A0T
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![BU of 2a0t by Molmil](/molmil-images/mine/2a0t) | NMR structure of the FHA1 domain of Rad53 in complex with a biological relevant phosphopeptide derived from Madt1 | 分子名称: | Hypothetical 73.8 kDa protein in SAS3-SEC17 intergenic region, residues 301-310, Serine/threonine-protein kinase RAD53 | 著者 | Mahajan, A, Yuan, C, Pike, B.L, Heierhorst, J, Chang, C.-F, Tsai, M.-D. | 登録日 | 2005-06-16 | 公開日 | 2005-11-08 | 最終更新日 | 2022-03-09 | 実験手法 | SOLUTION NMR | 主引用文献 | FHA Domain-Ligand Interactions: Importance of Integrating Chemical and Biological Approaches J.Am.Chem.Soc., 127, 2005
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4QTI
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![BU of 4qti by Molmil](/molmil-images/mine/4qti) | Crystal structure of human uPAR in complex with anti-uPAR Fab 8B12 | 分子名称: | Urokinase plasminogen activator surface receptor, anti-uPAR antibody, heavy chain, ... | 著者 | Zhao, B, Yuan, C, Luo, Z, Huang, M. | 登録日 | 2014-07-08 | 公開日 | 2015-02-25 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Stabilizing a flexible interdomain hinge region harboring the SMB binding site drives uPAR into its closed conformation. J.Mol.Biol., 427, 2015
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4QTH
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![BU of 4qth by Molmil](/molmil-images/mine/4qth) | Crystal structure of anti-uPAR Fab 8B12 | 分子名称: | anti-uPAR antibody, heavy chain, light chain | 著者 | Zhao, B, Yuan, C, Luo, Z, Huang, M. | 登録日 | 2014-07-08 | 公開日 | 2015-02-25 | 最終更新日 | 2022-08-24 | 実験手法 | X-RAY DIFFRACTION (2.17 Å) | 主引用文献 | Stabilizing a flexible interdomain hinge region harboring the SMB binding site drives uPAR into its closed conformation. J.Mol.Biol., 427, 2015
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3KHV
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![BU of 3khv by Molmil](/molmil-images/mine/3khv) | Crystal Structures of Urokinase-type Plasminogen Activator in Complex with 4-(Aminomethyl) Benzoic Acid and 4-(Aminomethyl-phenyl)-methanol | 分子名称: | SULFATE ION, TRIETHYLENE GLYCOL, Urokinase-type plasminogen activator, ... | 著者 | Jiang, L.-G, Zhao, G.-X, Bian, X.-B, Yuan, C, Huang, Z.-X, Huang, M.-D. | 登録日 | 2009-10-30 | 公開日 | 2009-12-01 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Crystal Structures of Urokinase-type Plasminogen Activator in Complex with 4-(Aminomethyl) Benzoic Acid and 4-(Aminomethyl-phenyl)-methanol CHIN.J.STRUCT.CHEM., 28, 2009
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3KID
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![BU of 3kid by Molmil](/molmil-images/mine/3kid) | The Crystal Structures of 2-Aminobenzothiazole-based Inhibitors in Complexes with Urokinase-type Plasminogen Activator | 分子名称: | Urokinase-type plasminogen activator, ethyl 2-amino-1,3-benzothiazole-6-carboxylate | 著者 | Jiang, L.-G, Yu, H.Y, Yuan, C, Wang, J.D, Chen, L.Q, Meehan, E.J, Huang, Z.-X, Huang, M.-D. | 登録日 | 2009-11-01 | 公開日 | 2009-12-01 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.71 Å) | 主引用文献 | Crystal Structures of 2-Aminobenzothiazole-based Inhibitors in Complexes with Urokinase-type Plasminogen Activator CHIN.J.STRUCT.CHEM., 28, 2009
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3KGP
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![BU of 3kgp by Molmil](/molmil-images/mine/3kgp) | Crystal Structures of Urokinase-type Plasminogen Activator in Complex with 4-(Aminomethyl) Benzoic Acid and 4-(Aminomethyl-phenyl)-methanol | 分子名称: | 4-(aminomethyl)benzoic acid, SULFATE ION, Urokinase-type plasminogen activator | 著者 | Jiang, L.-G, Zhao, G.-X, Bian, X.-B, Yuan, C, Huang, Z.-X, Huang, M.-D. | 登録日 | 2009-10-29 | 公開日 | 2009-12-01 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Crystal Structures of Urokinase-type Plasminogen Activator in Complex with 4-(Aminomethyl) Benzoic Acid and 4-(Aminomethyl-phenyl)-methanol CHIN.J.STRUCT.CHEM., 28, 2009
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2FMX
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![BU of 2fmx by Molmil](/molmil-images/mine/2fmx) | An open conformation of switch I revealed by Sar1-GDP crystal structure at low Mg(2+) | 分子名称: | GTP-binding protein SAR1b, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Rao, Y, Bian, C, Yuan, C, Li, Y, Huang, M. | 登録日 | 2006-01-10 | 公開日 | 2006-09-05 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.82 Å) | 主引用文献 | An open conformation of switch I revealed by Sar1-GDP crystal structure at low Mg(2+) Biochem.Biophys.Res.Commun., 348, 2006
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3TKZ
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![BU of 3tkz by Molmil](/molmil-images/mine/3tkz) | Structure of the SHP-2 N-SH2 domain in a 1:2 complex with RVIpYFVPLNR peptide | 分子名称: | PROTEIN (RVIpYFVPLNR peptide), Tyrosine-protein phosphatase non-receptor type 11 | 著者 | Zhang, Y, Zhang, J, Yuan, C, Hard, R.L, Park, I.H, Li, C, Bell, C.E, Pei, D. | 登録日 | 2011-08-29 | 公開日 | 2011-10-26 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Simultaneous binding of two peptidyl ligands by a SRC homology 2 domain. Biochemistry, 50, 2011
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2NWN
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![BU of 2nwn by Molmil](/molmil-images/mine/2nwn) | New Pharmacophore for Serine Protease Inhibition Revealed by Crystal Structure of Human Urokinase-type Plasminogen Activator Complexed with a Cyclic Peptidyl Inhibitor, upain-1 | 分子名称: | Plasminogen activator, urokinase, upain-1 | 著者 | Zhao, G, Yuan, C, Wind, T, Andreasen, P.A, Huang, Z, Huang, M, Structural Genomics Consortium (SGC) | 登録日 | 2006-11-16 | 公開日 | 2007-10-16 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Structural basis of specificity of a peptidyl urokinase inhibitor, upain-1 J.Struct.Biol., 160, 2007
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3TL0
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![BU of 3tl0 by Molmil](/molmil-images/mine/3tl0) | Structure of SHP2 N-SH2 domain in complex with RLNpYAQLWHR peptide | 分子名称: | RLNpYAQLWHR peptide, SULFATE ION, Tyrosine-protein phosphatase non-receptor type 11 | 著者 | Zhang, Y, Zhang, J, Yuan, C, Hard, R.L, Park, I.H, Li, C, Bell, C.E, Pei, D. | 登録日 | 2011-08-29 | 公開日 | 2011-09-28 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Simultaneous binding of two peptidyl ligands by a SRC homology 2 domain. Biochemistry, 50, 2011
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3U74
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![BU of 3u74 by Molmil](/molmil-images/mine/3u74) | Crystal structure of stabilized human uPAR mutant | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Urokinase plasminogen activator surface receptor | 著者 | Huang, M.D, Xu, X, Yuan, C. | 登録日 | 2011-10-13 | 公開日 | 2012-04-18 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.39 Å) | 主引用文献 | Crystal structure of the urokinase receptor in a ligand-free form. J.Mol.Biol., 416, 2012
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3U73
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![BU of 3u73 by Molmil](/molmil-images/mine/3u73) | Crystal structure of stabilized human uPAR mutant in complex with ATF | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Urokinase plasminogen activator surface receptor, Urokinase-type plasminogen activator, ... | 著者 | Huang, M.D, Xu, X, Yuan, C. | 登録日 | 2011-10-13 | 公開日 | 2012-04-18 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (3.19 Å) | 主引用文献 | Crystal structure of the urokinase receptor in a ligand-free form. J.Mol.Biol., 416, 2012
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6JRG
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![BU of 6jrg by Molmil](/molmil-images/mine/6jrg) | Crystal structure of ZmMoc1 H253A mutant in complex with Holliday junction | 分子名称: | DNA (32-MER), DNA (33-MER), MAGNESIUM ION, ... | 著者 | Lin, Z, Lin, H, Zhang, D, Yuan, C. | 登録日 | 2019-04-03 | 公開日 | 2019-10-23 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.005 Å) | 主引用文献 | Structural basis of sequence-specific Holliday junction cleavage by MOC1. Nat.Chem.Biol., 15, 2019
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3HNB
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![BU of 3hnb by Molmil](/molmil-images/mine/3hnb) | |
3HOB
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![BU of 3hob by Molmil](/molmil-images/mine/3hob) | |
2O8U
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![BU of 2o8u by Molmil](/molmil-images/mine/2o8u) | Crystal Structure and Binding Epitopes of Urokinase-type Plasminogen Activator (C122A/N145Q/S195A) in complex with Inhibitors | 分子名称: | BENZAMIDINE, DI(HYDROXYETHYL)ETHER, SULFATE ION, ... | 著者 | Zhao, G, Yuan, C, Jiang, L, Huang, Z, Huang, M. | 登録日 | 2006-12-12 | 公開日 | 2007-12-25 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Crystal Structure and Binding Epitopes of Urokinase-type Plasminogen Activator (C122A/N145Q/S195A) in complex with Inhibitors To be Published
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2O8T
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![BU of 2o8t by Molmil](/molmil-images/mine/2o8t) | Crystal Structure and Binding Epitopes of Urokinase-type Plasminogen Activator (C122A/N145Q) in complex with Inhibitors | 分子名称: | DI(HYDROXYETHYL)ETHER, PENTAETHYLENE GLYCOL, SULFATE ION, ... | 著者 | Zhao, G, Yuan, C, Jiang, L, Huang, Z, Huang, M. | 登録日 | 2006-12-12 | 公開日 | 2007-12-25 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Crystal Structure and Binding Epitopes of Urokinase-type Plasminogen Activator (C122A/N145Q/S195A) in complex with Inhibitors To be Published
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2O8W
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![BU of 2o8w by Molmil](/molmil-images/mine/2o8w) | Crystal Structure and Binding Epitopes of Urokinase-type Plasminogen Activator (C122A/N145Q/S195A) in complex with Inhibitors | 分子名称: | 1-phenylguanidine, SULFATE ION, TETRAETHYLENE GLYCOL, ... | 著者 | Zhao, G, Yuan, C, Jiang, L, Huang, Z, Huang, M. | 登録日 | 2006-12-12 | 公開日 | 2007-12-25 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | 主引用文献 | Crystal Structure and Binding Epitopes of Urokinase-type Plasminogen Activator (C122A/N145Q/S195A) in complex with Inhibitors To be Published
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