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PDB: 83 件
4DW2
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BU of 4dw2 by Molmil
The crystal structure of uPA in complex with the Fab fragment of mAb-112
分子名称: Fab fragment of pro-uPA antibody mAb-112, SULFATE ION, Urokinase-type plasminogen activator
著者Jiang, L, Botkjaer, K.A, Andersen, L.M, Yuan, C, Andreasen, P.A, Huang, M.
登録日2012-02-24
公開日2013-01-16
実験手法X-RAY DIFFRACTION (2.97 Å)
主引用文献Rezymogenation of active urokinase induced by an inhibitory antibody.
Biochem.J., 449, 2013
6XVD
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BU of 6xvd by Molmil
Crystal structure of complex of urokinase and a upain-1 variant(W3F) in pH7.4 condition
分子名称: Urokinase-type plasminogen activator, upain-1-W3F
著者Xue, G.P, Xie, X, Zhou, Y, Yuan, C, Huang, M.D, Jiang, L.G.
登録日2020-01-21
公開日2020-02-19
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Insight to the residue in P2 position prevents the peptide inhibitor from being hydrolyzed by serine proteases.
Biosci.Biotechnol.Biochem., 84, 2020
4DVA
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BU of 4dva by Molmil
The crystal structure of human urokinase-type plasminogen activator catalytic domain
分子名称: HEXAETHYLENE GLYCOL, SULFATE ION, Urokinase-type plasminogen activator
著者Jiang, L, Botkjaer, K.A, Andersen, L.M, Yuan, C, Andreasen, P.A, Huang, M.
登録日2012-02-23
公開日2013-01-16
実験手法X-RAY DIFFRACTION (1.94 Å)
主引用文献Rezymogenation of active urokinase induced by an inhibitory antibody
Biochem.J., 449, 2013
1LXC
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BU of 1lxc by Molmil
Crystal Structure of E. Coli Enoyl Reductase-NAD+ with a Bound Acrylamide Inhibitor
分子名称: 3-(6-AMINOPYRIDIN-3-YL)-N-METHYL-N-[(1-METHYL-1H-INDOL-2-YL)METHYL]ACRYLAMIDE, ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE
著者Miller, W.H, Seefeld, M.A, Newlander, K.A, Uzinskas, I.N, Burgess, W.J, Heerding, D.A, Yuan, C.C.K, Head, M.S, Payne, D.J, Rittenhouse, S.F, Moore, T.D, Pearson, S.C, Dewolf, V, Berry, W.E, Keller, P.M, Polizzi, B.J, Qiu, X, Janson, C.A, Huffman, W.F.
登録日2002-06-05
公開日2002-09-04
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Discovery of aminopyridine-based inhibitors of bacterial enoyl-ACP reductase (FabI).
J.Med.Chem., 45, 2002
4DVB
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BU of 4dvb by Molmil
The crystal structure of the Fab fragment of pro-uPA antibody mAb-112
分子名称: Fab fragment of pro-uPA antibody mAb-112, SULFATE ION, TETRAETHYLENE GLYCOL
著者Jiang, L, Botkjaer, K.A, Andersen, L.M, Yuan, C, Andreasen, P.A, Huang, M.
登録日2012-02-23
公開日2013-01-16
実験手法X-RAY DIFFRACTION (1.93 Å)
主引用文献Rezymogenation of active urokinase induced by an inhibitory antibody.
Biochem.J., 449, 2013
6BV7
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BU of 6bv7 by Molmil
NMR structure of Sodium/Calcium Exchanger 1 (NCX1) Two-helix Bundle (THB) domain
分子名称: Sodium/calcium exchanger 1
著者Yuan, J, Yuan, C, Bruschweiler, R.
登録日2017-12-12
公開日2018-06-20
最終更新日2024-05-01
実験手法SOLUTION NMR
主引用文献The Intracellular Loop of the Na+/Ca2+Exchanger Contains an "Awareness Ribbon"-Shaped Two-Helix Bundle Domain.
Biochemistry, 57, 2018
3G7N
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BU of 3g7n by Molmil
Crystal Structure of a Triacylglycerol Lipase from Penicillium Expansum at 1.3
分子名称: DI(HYDROXYETHYL)ETHER, Lipase, PENTAETHYLENE GLYCOL, ...
著者Bian, C.B, Yuan, C, Chen, L.Q, Edward, J.M, Lin, L, Jiang, L.G, Huang, Z.X, Huang, M.D.
登録日2009-02-10
公開日2010-02-23
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Crystal structure of a triacylglycerol lipase from Penicillium expansum at 1.3 A determined by sulfur SAD
Proteins, 78, 2010
2A0T
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BU of 2a0t by Molmil
NMR structure of the FHA1 domain of Rad53 in complex with a biological relevant phosphopeptide derived from Madt1
分子名称: Hypothetical 73.8 kDa protein in SAS3-SEC17 intergenic region, residues 301-310, Serine/threonine-protein kinase RAD53
著者Mahajan, A, Yuan, C, Pike, B.L, Heierhorst, J, Chang, C.-F, Tsai, M.-D.
登録日2005-06-16
公開日2005-11-08
最終更新日2022-03-09
実験手法SOLUTION NMR
主引用文献FHA Domain-Ligand Interactions: Importance of Integrating Chemical and Biological Approaches
J.Am.Chem.Soc., 127, 2005
4QTI
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BU of 4qti by Molmil
Crystal structure of human uPAR in complex with anti-uPAR Fab 8B12
分子名称: Urokinase plasminogen activator surface receptor, anti-uPAR antibody, heavy chain, ...
著者Zhao, B, Yuan, C, Luo, Z, Huang, M.
登録日2014-07-08
公開日2015-02-25
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Stabilizing a flexible interdomain hinge region harboring the SMB binding site drives uPAR into its closed conformation.
J.Mol.Biol., 427, 2015
4QTH
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BU of 4qth by Molmil
Crystal structure of anti-uPAR Fab 8B12
分子名称: anti-uPAR antibody, heavy chain, light chain
著者Zhao, B, Yuan, C, Luo, Z, Huang, M.
登録日2014-07-08
公開日2015-02-25
最終更新日2022-08-24
実験手法X-RAY DIFFRACTION (2.17 Å)
主引用文献Stabilizing a flexible interdomain hinge region harboring the SMB binding site drives uPAR into its closed conformation.
J.Mol.Biol., 427, 2015
3KHV
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BU of 3khv by Molmil
Crystal Structures of Urokinase-type Plasminogen Activator in Complex with 4-(Aminomethyl) Benzoic Acid and 4-(Aminomethyl-phenyl)-methanol
分子名称: SULFATE ION, TRIETHYLENE GLYCOL, Urokinase-type plasminogen activator, ...
著者Jiang, L.-G, Zhao, G.-X, Bian, X.-B, Yuan, C, Huang, Z.-X, Huang, M.-D.
登録日2009-10-30
公開日2009-12-01
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Crystal Structures of Urokinase-type Plasminogen Activator in Complex with 4-(Aminomethyl) Benzoic Acid and 4-(Aminomethyl-phenyl)-methanol
CHIN.J.STRUCT.CHEM., 28, 2009
3KID
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BU of 3kid by Molmil
The Crystal Structures of 2-Aminobenzothiazole-based Inhibitors in Complexes with Urokinase-type Plasminogen Activator
分子名称: Urokinase-type plasminogen activator, ethyl 2-amino-1,3-benzothiazole-6-carboxylate
著者Jiang, L.-G, Yu, H.Y, Yuan, C, Wang, J.D, Chen, L.Q, Meehan, E.J, Huang, Z.-X, Huang, M.-D.
登録日2009-11-01
公開日2009-12-01
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.71 Å)
主引用文献Crystal Structures of 2-Aminobenzothiazole-based Inhibitors in Complexes with Urokinase-type Plasminogen Activator
CHIN.J.STRUCT.CHEM., 28, 2009
3KGP
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BU of 3kgp by Molmil
Crystal Structures of Urokinase-type Plasminogen Activator in Complex with 4-(Aminomethyl) Benzoic Acid and 4-(Aminomethyl-phenyl)-methanol
分子名称: 4-(aminomethyl)benzoic acid, SULFATE ION, Urokinase-type plasminogen activator
著者Jiang, L.-G, Zhao, G.-X, Bian, X.-B, Yuan, C, Huang, Z.-X, Huang, M.-D.
登録日2009-10-29
公開日2009-12-01
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Crystal Structures of Urokinase-type Plasminogen Activator in Complex with 4-(Aminomethyl) Benzoic Acid and 4-(Aminomethyl-phenyl)-methanol
CHIN.J.STRUCT.CHEM., 28, 2009
2FMX
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BU of 2fmx by Molmil
An open conformation of switch I revealed by Sar1-GDP crystal structure at low Mg(2+)
分子名称: GTP-binding protein SAR1b, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
著者Rao, Y, Bian, C, Yuan, C, Li, Y, Huang, M.
登録日2006-01-10
公開日2006-09-05
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.82 Å)
主引用文献An open conformation of switch I revealed by Sar1-GDP crystal structure at low Mg(2+)
Biochem.Biophys.Res.Commun., 348, 2006
3TKZ
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BU of 3tkz by Molmil
Structure of the SHP-2 N-SH2 domain in a 1:2 complex with RVIpYFVPLNR peptide
分子名称: PROTEIN (RVIpYFVPLNR peptide), Tyrosine-protein phosphatase non-receptor type 11
著者Zhang, Y, Zhang, J, Yuan, C, Hard, R.L, Park, I.H, Li, C, Bell, C.E, Pei, D.
登録日2011-08-29
公開日2011-10-26
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Simultaneous binding of two peptidyl ligands by a SRC homology 2 domain.
Biochemistry, 50, 2011
2NWN
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BU of 2nwn by Molmil
New Pharmacophore for Serine Protease Inhibition Revealed by Crystal Structure of Human Urokinase-type Plasminogen Activator Complexed with a Cyclic Peptidyl Inhibitor, upain-1
分子名称: Plasminogen activator, urokinase, upain-1
著者Zhao, G, Yuan, C, Wind, T, Andreasen, P.A, Huang, Z, Huang, M, Structural Genomics Consortium (SGC)
登録日2006-11-16
公開日2007-10-16
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Structural basis of specificity of a peptidyl urokinase inhibitor, upain-1
J.Struct.Biol., 160, 2007
3TL0
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BU of 3tl0 by Molmil
Structure of SHP2 N-SH2 domain in complex with RLNpYAQLWHR peptide
分子名称: RLNpYAQLWHR peptide, SULFATE ION, Tyrosine-protein phosphatase non-receptor type 11
著者Zhang, Y, Zhang, J, Yuan, C, Hard, R.L, Park, I.H, Li, C, Bell, C.E, Pei, D.
登録日2011-08-29
公開日2011-09-28
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Simultaneous binding of two peptidyl ligands by a SRC homology 2 domain.
Biochemistry, 50, 2011
3U74
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BU of 3u74 by Molmil
Crystal structure of stabilized human uPAR mutant
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Urokinase plasminogen activator surface receptor
著者Huang, M.D, Xu, X, Yuan, C.
登録日2011-10-13
公開日2012-04-18
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.39 Å)
主引用文献Crystal structure of the urokinase receptor in a ligand-free form.
J.Mol.Biol., 416, 2012
3U73
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BU of 3u73 by Molmil
Crystal structure of stabilized human uPAR mutant in complex with ATF
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Urokinase plasminogen activator surface receptor, Urokinase-type plasminogen activator, ...
著者Huang, M.D, Xu, X, Yuan, C.
登録日2011-10-13
公開日2012-04-18
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (3.19 Å)
主引用文献Crystal structure of the urokinase receptor in a ligand-free form.
J.Mol.Biol., 416, 2012
6JRG
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BU of 6jrg by Molmil
Crystal structure of ZmMoc1 H253A mutant in complex with Holliday junction
分子名称: DNA (32-MER), DNA (33-MER), MAGNESIUM ION, ...
著者Lin, Z, Lin, H, Zhang, D, Yuan, C.
登録日2019-04-03
公開日2019-10-23
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.005 Å)
主引用文献Structural basis of sequence-specific Holliday junction cleavage by MOC1.
Nat.Chem.Biol., 15, 2019
3HNB
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BU of 3hnb by Molmil
Factor VIII Trp2313-His2315 segment is involved in membrane binding as shown by crystal structure of complex between factor VIII C2 domain and an inhibitor
分子名称: (2R)-1-(2,4-dichlorophenoxy)-3-[(2E)-2-imino-3-(2-piperidin-1-ylethyl)-2,3-dihydro-1H-benzimidazol-1-yl]propan-2-ol, Coagulation factor VIII
著者Liu, Z, Yuan, C.
登録日2009-05-31
公開日2010-01-19
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.15 Å)
主引用文献Trp2313-His2315 of factor VIII C2 domain is involved in membrane binding: structure of a complex between the C2 domain and an inhibitor of membrane binding.
J.Biol.Chem., 285, 2010
3HOB
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BU of 3hob by Molmil
Factor VIII Trp2313-His2315 segment is involved in membrane binding as shown by crystal structure of complex between factor VIII C2 domain and an inhibitor
分子名称: Coagulation factor VIII
著者Liu, Z, Yuan, C.
登録日2009-06-01
公開日2010-01-19
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.07 Å)
主引用文献Trp2313-His2315 of factor VIII C2 domain is involved in membrane binding: structure of a complex between the C2 domain and an inhibitor of membrane binding.
J.Biol.Chem., 285, 2010
2O8U
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BU of 2o8u by Molmil
Crystal Structure and Binding Epitopes of Urokinase-type Plasminogen Activator (C122A/N145Q/S195A) in complex with Inhibitors
分子名称: BENZAMIDINE, DI(HYDROXYETHYL)ETHER, SULFATE ION, ...
著者Zhao, G, Yuan, C, Jiang, L, Huang, Z, Huang, M.
登録日2006-12-12
公開日2007-12-25
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Crystal Structure and Binding Epitopes of Urokinase-type Plasminogen Activator (C122A/N145Q/S195A) in complex with Inhibitors
To be Published
2O8T
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Crystal Structure and Binding Epitopes of Urokinase-type Plasminogen Activator (C122A/N145Q) in complex with Inhibitors
分子名称: DI(HYDROXYETHYL)ETHER, PENTAETHYLENE GLYCOL, SULFATE ION, ...
著者Zhao, G, Yuan, C, Jiang, L, Huang, Z, Huang, M.
登録日2006-12-12
公開日2007-12-25
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Crystal Structure and Binding Epitopes of Urokinase-type Plasminogen Activator (C122A/N145Q/S195A) in complex with Inhibitors
To be Published
2O8W
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Crystal Structure and Binding Epitopes of Urokinase-type Plasminogen Activator (C122A/N145Q/S195A) in complex with Inhibitors
分子名称: 1-phenylguanidine, SULFATE ION, TETRAETHYLENE GLYCOL, ...
著者Zhao, G, Yuan, C, Jiang, L, Huang, Z, Huang, M.
登録日2006-12-12
公開日2007-12-25
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.86 Å)
主引用文献Crystal Structure and Binding Epitopes of Urokinase-type Plasminogen Activator (C122A/N145Q/S195A) in complex with Inhibitors
To be Published

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