3HNB

Factor VIII Trp2313-His2315 segment is involved in membrane binding as shown by crystal structure of complex between factor VIII C2 domain and an inhibitor

Summary for 3HNB

• Entry DOI: 10.2210/pdb3hnb/pdb
• Descriptor: Coagulation factor VIII, (2R)-1-(2,4-dichlorophenoxy)-3-[(2E)-2-imino-3-(2-piperidin-1-ylethyl)-2,3-dihydro-1H-benzimidazol-1-yl]propan-2-ol (3 entities in total)
• Functional Keywords: small molecule inhibitor/blood clotting, blood clotting
• Biological source: Homo sapiens (human)
• Cellular location: Secreted, extracellular space: P00451
• Total number of polymer chains: 1
• Total formula weight: 18492.96

Authors

Liu, Z.,Yuan, C. (deposition date: 2009-05-31, release date: 2010-01-19, Last modification date: 2023-11-01)

• Primary citation: Liu, Z.,Lin, L.,Yuan, C.,Nicolaes, G.A.,Chen, L.,Meehan, E.J.,Furie, B.,Furie, B.,Huang, M.; Trp2313-His2315 of factor VIII C2 domain is involved in membrane binding: structure of a complex between the C2 domain and an inhibitor of membrane binding.; J.Biol.Chem., 285:8824-8829, 2010; PubMed: 20089867; DOI: 10.1074/jbc.M109.080168

Experimental method

X-RAY DIFFRACTION (1.15 Å)