1LXC
Crystal Structure of E. Coli Enoyl Reductase-NAD+ with a Bound Acrylamide Inhibitor
Summary for 1LXC
Entry DOI | 10.2210/pdb1lxc/pdb |
Related | 1C14 1I2Z 1I30 1LX6 1QG6 |
Descriptor | ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE, 3-(6-AMINOPYRIDIN-3-YL)-N-METHYL-N-[(1-METHYL-1H-INDOL-2-YL)METHYL]ACRYLAMIDE, ... (4 entities in total) |
Functional Keywords | fabi, enoyl reductase, oxidoreductase |
Biological source | Escherichia coli |
Total number of polymer chains | 2 |
Total formula weight | 57753.48 |
Authors | Miller, W.H.,Seefeld, M.A.,Newlander, K.A.,Uzinskas, I.N.,Burgess, W.J.,Heerding, D.A.,Yuan, C.C.K.,Head, M.S.,Payne, D.J.,Rittenhouse, S.F.,Moore, T.D.,Pearson, S.C.,Dewolf, V.,Berry, W.E.,Keller, P.M.,Polizzi, B.J.,Qiu, X.,Janson, C.A.,Huffman, W.F. (deposition date: 2002-06-05, release date: 2002-09-04, Last modification date: 2024-02-14) |
Primary citation | Miller, W.H.,Seefeld, M.A.,Newlander, K.A.,Uzinskas, I.N.,Burgess, W.J.,Heerding, D.A.,Yuan, C.C.,Head, M.S.,Payne, D.J.,Rittenhouse, S.F.,Moore, T.D.,Pearson, S.C.,Berry, V.,DeWolf Jr., W.E.,Keller, P.M.,Polizzi, B.J.,Qiu, X.,Janson, C.A.,Huffman, W.F. Discovery of aminopyridine-based inhibitors of bacterial enoyl-ACP reductase (FabI). J.Med.Chem., 45:3246-3256, 2002 Cited by PubMed: 12109908DOI: 10.1021/jm020050+ PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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