2NWN

New Pharmacophore for Serine Protease Inhibition Revealed by Crystal Structure of Human Urokinase-type Plasminogen Activator Complexed with a Cyclic Peptidyl Inhibitor, upain-1

Summary for 2NWN

Entry DOI	10.2210/pdb2nwn/pdb
Descriptor	Plasminogen activator, urokinase, upain-1 (3 entities in total)
Functional Keywords	urokinase-type plasminogen activator, peptidyl inhibitor, pharmacophore, structural genomics, structural genomics consortium, sgc, hydrolase
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	29937.12
Authors	Zhao, G.,Yuan, C.,Wind, T.,Andreasen, P.A.,Huang, Z.,Huang, M.,Structural Genomics Consortium (SGC) (deposition date: 2006-11-16, release date: 2007-10-16, Last modification date: 2023-10-25)
Primary citation	Zhao, G.,Yuan, C.,Wind, T.,Huang, Z.,Andreasen, P.A.,Huang, M. Structural basis of specificity of a peptidyl urokinase inhibitor, upain-1 J.Struct.Biol., 160:1-10, 2007 Cited by PubMed: 17692534 DOI: 10.1016/j.jsb.2007.06.003 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.15 Å)

Structure validation