2NWN
New Pharmacophore for Serine Protease Inhibition Revealed by Crystal Structure of Human Urokinase-type Plasminogen Activator Complexed with a Cyclic Peptidyl Inhibitor, upain-1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Plasminogen activator, urokinase | polymer | 253 | 28442.4 | 1 | UniProt (Q53XS3) Pfam (PF00089) UniProt (by SIFTS) (P00749) | Homo sapiens (human) | uPA |
| 2 | B (B) | upain-1 | polymer | 12 | 1494.7 | 1 | |||
| 3 | C, D (A, B) | water | water | 18.0 | 133 | Chemie (HOH) |
Sequence modifications
A: 16 - 250 (UniProt: Q53XS3)
| PDB | External Database | Details |
|---|---|---|
| Ala 122 | Cys 299 | engineered mutation |
| Gln 145 | Asn 322 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 29937.1 | |
| All* | Total formula weight | 29937.1 |
