5QBV
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5qbv by Molmil](/molmil-images/mine/5qbv) | Crystal structure of human Cathepsin-S with bound ligand | Descriptor: | Cathepsin S, N-[2-chloro-5-(1-{3-[4-(6-chloro-3-methyl-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]propyl}-6-oxo-1,6-dihydropyridazin-3-yl)benzyl]benzamide | Authors: | Bembenek, S.D, Ameriks, M.K, Mirzadegan, T, Yang, H, Shao, C, Burley, S.K. | Deposit date: | 2017-08-04 | Release date: | 2017-12-20 | Last modified: | 2021-11-17 | Method: | X-RAY DIFFRACTION (1.796 Å) | Cite: | Diazinones as P2 replacements for pyrazole-based cathepsin S inhibitors Bioorg.Med.Chem.Lett., 20, 2010
|
|
5WBU
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5wbu by Molmil](/molmil-images/mine/5wbu) | |
5QBY
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5qby by Molmil](/molmil-images/mine/5qby) | Crystal structure of human Cathepsin-S with bound ligand | Descriptor: | Cathepsin S, N-[2-chloro-5-(1-{3-[4-(6-chloro-3-methyl-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]propyl}-6-oxo-1,6-dihydropyrimidin-5-yl)benzyl]-4-fluorobenzamide | Authors: | Bembenek, S.D, Ameriks, M.K, Mirzadegan, T, Yang, H, Shao, C, Burley, S.K. | Deposit date: | 2017-08-04 | Release date: | 2017-12-20 | Last modified: | 2021-11-17 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Diazinones as P2 replacements for pyrazole-based cathepsin S inhibitors Bioorg.Med.Chem.Lett., 20, 2010
|
|
5QC4
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5qc4 by Molmil](/molmil-images/mine/5qc4) | Crystal structure of human Cathepsin-S with bound ligand | Descriptor: | 2-[5-[5-ethanoyl-1-[(2~{R})-2-oxidanyl-3-[4-(2-oxidanylpropan-2-yl)piperidin-1-yl]propyl]-6,7-dihydro-4~{H}-pyrazolo[4,3-c]pyridin-3-yl]-2-(trifluoromethyl)phenyl]sulfanyl-1-pyrrolidin-1-yl-ethanone, Cathepsin S | Authors: | Bembenek, S.D, Ameriks, M.K, Mirzadegan, T, Yang, H, Shao, C, Burley, S.K. | Deposit date: | 2017-08-04 | Release date: | 2017-12-20 | Last modified: | 2021-11-17 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Thioether acetamides as P3 binding elements for tetrahydropyrido-pyrazole cathepsin S inhibitors. Bioorg.Med.Chem.Lett., 20, 2010
|
|
5EU8
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5eu8 by Molmil](/molmil-images/mine/5eu8) | Structure of FIPV main protease in complex with dual inhibitors | Descriptor: | 1,2-ETHANEDIOL, N-[(5-METHYLISOXAZOL-3-YL)CARBONYL]ALANYL-L-VALYL-N~1~-((1R,2Z)-4-(BENZYLOXY)-4-OXO-1-{[(3R)-2-OXOPYRROLIDIN-3-YL]METHYL}BUT-2-ENYL)-L-LEUCINAMIDE, ZINC ION, ... | Authors: | Wang, F, Chen, C, Liu, X, Yang, K, Xu, X, Yang, H. | Deposit date: | 2015-11-18 | Release date: | 2015-12-30 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.447 Å) | Cite: | Crystal Structure of Feline Infectious Peritonitis Virus Main Protease in Complex with Synergetic Dual Inhibitors J.Virol., 90, 2015
|
|
5H2C
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5h2c by Molmil](/molmil-images/mine/5h2c) | Crystal structure of Saccharomyces cerevisiae Osh1 ANK - Nvj1 | Descriptor: | Nucleus-vacuole junction protein 1, Oxysterol-binding protein homolog 1 | Authors: | Im, Y.J, Manik, M.K, Yang, H.S, Tong, J.S. | Deposit date: | 2016-10-14 | Release date: | 2017-05-10 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (3.508 Å) | Cite: | Structure of Yeast OSBP-Related Protein Osh1 Reveals Key Determinants for Lipid Transport and Protein Targeting at the Nucleus-Vacuole Junction Structure, 25, 2017
|
|
5H2D
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5h2d by Molmil](/molmil-images/mine/5h2d) | Crystal structure of Osh1 ORD domain in complex with ergosterol | Descriptor: | ERGOSTEROL, KLLA0C04147p, SULFATE ION | Authors: | Im, Y.J, Manik, M.K, Yang, H.S, Tong, J.S. | Deposit date: | 2016-10-14 | Release date: | 2017-05-10 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structure of Yeast OSBP-Related Protein Osh1 Reveals Key Determinants for Lipid Transport and Protein Targeting at the Nucleus-Vacuole Junction Structure, 25, 2017
|
|
5D45
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5d45 by Molmil](/molmil-images/mine/5d45) | Crystal Structure of FABP4 in complex with 3-(5-cyclopropyl-2,3-diphenyl-1H-indol-1-yl)propanoic acid | Descriptor: | 3-(5-cyclopropyl-2,3-diphenyl-1H-indol-1-yl)propanoic acid, Fatty acid-binding protein, adipocyte | Authors: | Tagami, U, Takahashi, K, Igarashi, S, Ejima, C, Yoshida, T, Takeshita, S, Miyanaga, W, Sugiki, M, Tokumasu, M, Hatanaka, T, Kashiwagi, T, Ishikawa, K, Miyano, H, Mizukoshi, T. | Deposit date: | 2015-08-07 | Release date: | 2016-06-22 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Interaction Analysis of FABP4 Inhibitors by X-ray Crystallography and Fragment Molecular Orbital Analysis Acs Med.Chem.Lett., 7, 2016
|
|
5D48
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5d48 by Molmil](/molmil-images/mine/5d48) | Crystal Structure of FABP4 in complex with 3-{5-cyclopropyl-3-(3,5-dimethyl-1H-pyrazol-4-yl)-2-[3-(propan-2-yloxy) phenyl]-1H-indol-1-yl}propanoic acid | Descriptor: | 3-{5-cyclopropyl-3-(3,5-dimethyl-1H-pyrazol-4-yl)-2-[3-(propan-2-yloxy)phenyl]-1H-indol-1-yl}propanoic acid, Fatty acid-binding protein, adipocyte, ... | Authors: | Tagami, U, Takahashi, K, Igarashi, S, Ejima, C, Yoshida, T, Takeshita, S, Miyanaga, W, Sugiki, M, Tokumasu, M, Hatanaka, T, Kashiwagi, T, Ishikawa, K, Miyano, H, Mizukoshi, T. | Deposit date: | 2015-08-07 | Release date: | 2016-06-22 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.81 Å) | Cite: | Interaction Analysis of FABP4 Inhibitors by X-ray Crystallography and Fragment Molecular Orbital Analysis Acs Med.Chem.Lett., 7, 2016
|
|
2Q62
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2q62 by Molmil](/molmil-images/mine/2q62) | Crystal Structure of ArsH from Sinorhizobium meliloti | Descriptor: | SULFATE ION, arsH | Authors: | Ye, J, Yang, H, Bhattacharjee, H, Rosen, B.P. | Deposit date: | 2007-06-04 | Release date: | 2007-12-11 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structure of the flavoprotein ArsH from Sinorhizobium meliloti FEBS Lett., 581, 2007
|
|
5X8Y
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5x8y by Molmil](/molmil-images/mine/5x8y) | A Mutation identified in Neonatal Microcephaly Destabilizes Zika Virus NS1 Assembly in vitro | Descriptor: | ZIKV NS1 | Authors: | Wang, D, Chen, C, Liu, S, Zhou, H, Yang, K, Zhao, Q, Ji, X, Chen, C, Xie, W, Wang, Z, Mi, L.Z, Yang, H. | Deposit date: | 2017-03-03 | Release date: | 2017-05-17 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.817 Å) | Cite: | A Mutation Identified in Neonatal Microcephaly Destabilizes Zika Virus NS1 Assembly in Vitro Sci Rep, 7, 2017
|
|
2MNY
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2mny by Molmil](/molmil-images/mine/2mny) | NMR Structure of KDM5B PHD1 finger | Descriptor: | Lysine-specific demethylase 5B, ZINC ION | Authors: | Zhang, Y, Yang, H.R, Guo, X, Rong, N.Y, Song, Y.J, Xu, Y.W, Lan, W.X, Xu, Y.H, Cao, C. | Deposit date: | 2014-04-16 | Release date: | 2014-08-06 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | The PHD1 finger of KDM5B recognizes unmodified H3K4 during the demethylation of histone H3K4me2/3 by KDM5B. Protein Cell, 5, 2014
|
|
6LNB
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6lnb by Molmil](/molmil-images/mine/6lnb) | CryoEM structure of Cascade-TniQ-dsDNA complex | Descriptor: | CRISPR RNA (60-MER), CRISPR-associated protein Cas6, CRISPR-associated protein Cas7, ... | Authors: | Wang, B, Xu, W, Yang, H. | Deposit date: | 2019-12-28 | Release date: | 2020-02-19 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.18 Å) | Cite: | Structural basis of a Tn7-like transposase recruitment and DNA loading to CRISPR-Cas surveillance complex. Cell Res., 30, 2020
|
|
2MNZ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2mnz by Molmil](/molmil-images/mine/2mnz) | NMR Structure of KDM5B PHD1 finger in complex with H3K4me0(1-10aa) | Descriptor: | H3K4me0, Lysine-specific demethylase 5B, ZINC ION | Authors: | Zhang, Y, Yang, H.R, Guo, X, Rong, N.Y, Song, Y.J, Xu, Y.W, Lan, W.X, Xu, Y.H, Cao, C. | Deposit date: | 2014-04-16 | Release date: | 2014-08-06 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | The PHD1 finger of KDM5B recognizes unmodified H3K4 during the demethylation of histone H3K4me2/3 by KDM5B. Protein Cell, 5, 2014
|
|
6LNC
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6lnc by Molmil](/molmil-images/mine/6lnc) | CryoEM structure of Cascade-TniQ complex | Descriptor: | CRISPR RNA (60-MER), CRISPR-associated protein Cas6, CRISPR-associated protein Cas7, ... | Authors: | Wang, B, Xu, W, Yang, H. | Deposit date: | 2019-12-28 | Release date: | 2020-02-19 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.21 Å) | Cite: | Structural basis of a Tn7-like transposase recruitment and DNA loading to CRISPR-Cas surveillance complex. Cell Res., 30, 2020
|
|
5IAY
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5iay by Molmil](/molmil-images/mine/5iay) | NMR structure of UHRF1 Tandem Tudor Domains in a complex with Spacer peptide | Descriptor: | E3 ubiquitin-protein ligase UHRF1, Spacer | Authors: | Fang, J, Cheng, J, Wang, J, Zhang, Q, Liu, M, Gong, R, Wang, P, Zhang, X, Feng, Y, Lan, W, Gong, Z, Tang, C, Wong, J, Yang, H, Cao, C, Xu, Y. | Deposit date: | 2016-02-22 | Release date: | 2016-04-20 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Hemi-methylated DNA opens a closed conformation of UHRF1 to facilitate its histone recognition Nat Commun, 7, 2016
|
|
5WBY
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5wby by Molmil](/molmil-images/mine/5wby) | |
6NR2
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6nr2 by Molmil](/molmil-images/mine/6nr2) | Cryo-EM structure of the TRPM8 ion channel in complex with the menthol analog WS-12 and PI(4,5)P2 | Descriptor: | (1R,2S,5R)-N-(4-methoxyphenyl)-5-methyl-2-(propan-2-yl)cyclohexane-1-carboxamide, (2S)-1-{[(R)-hydroxy{[(1R,2R,3S,4R,5R,6S)-2,3,6-trihydroxy-4,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}-3-(octadecanoyloxy)propan-2-yl icosa-5,8,11,14-tetraenoate, Transient receptor potential cation channel subfamily M member 8 | Authors: | Yin, Y, Le, S.C, Hsu, A.L, Borgnia, M.J, Yang, H, Lee, S.-Y. | Deposit date: | 2019-01-22 | Release date: | 2019-02-20 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Structural basis of cooling agent and lipid sensing by the cold-activated TRPM8 channel. Science, 363, 2019
|
|
3OV8
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3ov8 by Molmil](/molmil-images/mine/3ov8) | Crystal structure of AF1382 from Archaeoglobus fulgidus, High resolution | Descriptor: | ACETATE ION, CHLORIDE ION, Protein AF_1382 | Authors: | Zhu, J.-Y, Zhao, M, Fu, Z.-Q, Yang, H, Chang, J, Hao, X, Chen, L, Rose, J.P, Wang, B.C, Southeast Collaboratory for Structural Genomics (SECSG) | Deposit date: | 2010-09-16 | Release date: | 2011-11-16 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.8501 Å) | Cite: | Structure of the Archaeoglobus fulgidus orphan ORF AF1382 determined by sulfur SAD from a moderately diffracting crystal. Acta Crystallogr.,Sect.D, 68, 2012
|
|
2G9T
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2g9t by Molmil](/molmil-images/mine/2g9t) | Crystal structure of the SARS coronavirus nsp10 at 2.1A | Descriptor: | ZINC ION, orf1a polyprotein | Authors: | Su, D, Lou, Z, Yang, H, Sun, F, Rao, Z. | Deposit date: | 2006-03-07 | Release date: | 2006-08-15 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Dodecamer Structure of Severe Acute Respiratory Syndrome Coronavirus Nonstructural Protein nsp10 J.Virol., 80, 2006
|
|
6NR3
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6nr3 by Molmil](/molmil-images/mine/6nr3) | Cryo-EM structure of the TRPM8 ion channel in complex with high occupancy icilin, PI(4,5)P2, and calcium | Descriptor: | (2S)-1-{[(R)-hydroxy{[(1R,2R,3S,4R,5R,6S)-2,3,6-trihydroxy-4,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}-3-(octadecanoyloxy)propan-2-yl icosa-5,8,11,14-tetraenoate, CALCIUM ION, Icilin, ... | Authors: | Yin, Y, Le, S.C, Hsu, A.L, Borgnia, M.J, Yang, H, Lee, S.-Y. | Deposit date: | 2019-01-22 | Release date: | 2019-02-20 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structural basis of cooling agent and lipid sensing by the cold-activated TRPM8 channel. Science, 363, 2019
|
|
6B3M
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6b3m by Molmil](/molmil-images/mine/6b3m) | The crystal structure of a broadly-reactive human anti-hemagglutinin stalk antibody (70-1F02) in complex with H5 hemagglutinin | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 70-1F02 Fab Heavy Chain, ... | Authors: | Shore, D.A, Yang, H, Stevens, J. | Deposit date: | 2017-09-22 | Release date: | 2018-06-13 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.92 Å) | Cite: | Broadly Reactive Human Monoclonal Antibodies Elicited following Pandemic H1N1 Influenza Virus Exposure Protect Mice against Highly Pathogenic H5N1 Challenge. J. Virol., 92, 2018
|
|
2GA6
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2ga6 by Molmil](/molmil-images/mine/2ga6) | The crystal structure of SARS nsp10 without zinc ion as additive | Descriptor: | ZINC ION, orf1a polyprotein | Authors: | Su, D, Lou, Z, Sun, F, Zhai, Y, Yang, H, Rao, Z. | Deposit date: | 2006-03-08 | Release date: | 2006-08-15 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Dodecamer Structure of Severe Acute Respiratory Syndrome Coronavirus Nonstructural Protein nsp10 J.Virol., 80, 2006
|
|
1N3K
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1n3k by Molmil](/molmil-images/mine/1n3k) | Solution structure of phosphoprotein enriched in astrocytes 15 kDa (PEA-15) | Descriptor: | Astrocytic phosphoprotein PEA-15 | Authors: | Hill, J.M, Vaidyanathan, H, Ramos, J.W, Ginsberg, M.H, Werner, M.H. | Deposit date: | 2002-10-28 | Release date: | 2003-01-14 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Recognition of ERK MAP Kinase by PEA-15 Reveals a Common Docking Site Within the Death Domain and Death Effector Domain Embo J., 21, 2002
|
|
4KW1
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4kw1 by Molmil](/molmil-images/mine/4kw1) | Structure of a/egypt/n03072/2010 h5 ha | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, ... | Authors: | Shore, D.A, Yang, H, Carney, P.J, Chang, J.C, Stevens, J. | Deposit date: | 2013-05-23 | Release date: | 2014-06-25 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural and antigenic variation among diverse clade 2 H5N1 viruses. Plos One, 8, 2013
|
|