2Q62
Crystal Structure of ArsH from Sinorhizobium meliloti
Summary for 2Q62
| Entry DOI | 10.2210/pdb2q62/pdb |
| Descriptor | arsH, SULFATE ION (3 entities in total) |
| Functional Keywords | alpha/beta, flavoprotein |
| Biological source | Sinorhizobium meliloti |
| Total number of polymer chains | 8 |
| Total formula weight | 224238.93 |
| Authors | Ye, J.,Yang, H.,Bhattacharjee, H.,Rosen, B.P. (deposition date: 2007-06-04, release date: 2007-12-11, Last modification date: 2024-02-21) |
| Primary citation | Ye, J.,Yang, H.,Rosen, B.P.,Bhattacharjee, H. Crystal structure of the flavoprotein ArsH from Sinorhizobium meliloti FEBS Lett., 581:3996-4000, 2007 Cited by PubMed Abstract: Purified ArsH from Sinorhizobium meliloti exhibits NADPH:FMN-dependent reduction of molecular O2 to hydrogen peroxide and catalyzes reduction of azo dyes. The structure of ArsH was determined at 1.8A resolution. ArsH crystallizes with eight molecules in the asymmetric unit forming two tetramers. Each monomer has a core domain with a central five-stranded parallel beta-sheet and two monomers interact to form a classical flavodoxin-like dimer. The N- and C-terminal extensions of ArsH are involved in interactions between subunits and tetramer formation. The structure may provide insight in how ArsH participates in arsenic detoxification. PubMed: 17673204DOI: 10.1016/j.febslet.2007.07.039 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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