7YI5
| Cryo-EM structure of Rpd3S complex bound to H3K36me3 nucleosome in loose state | 分子名称: | Chromatin modification-related protein EAF3, Histone H2A, Histone H2B 1.1, ... | 著者 | Li, H.T, Yan, C.Y, Guan, H.P, Wang, P. | 登録日 | 2022-07-14 | 公開日 | 2023-06-14 | 最終更新日 | 2023-08-30 | 実験手法 | ELECTRON MICROSCOPY (3.96 Å) | 主引用文献 | Diverse modes of H3K36me3-guided nucleosomal deacetylation by Rpd3S. Nature, 620, 2023
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8KCT
| Cryo-EM structure of human gamma-secretase in complex with Nirogacestat | 分子名称: | (2S)-2-[[(2S)-6,8-bis(fluoranyl)-1,2,3,4-tetrahydronaphthalen-2-yl]amino]-N-[1-[1-(2,2-dimethylpropylamino)-2-methyl-propan-2-yl]imidazol-4-yl]pentanamide, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Guo, X, Li, H, Kai, U, Yan, C, Lei, J, Zhou, R, Shi, Y. | 登録日 | 2023-08-08 | 公開日 | 2024-08-14 | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | 主引用文献 | Structural Basis of gamma-secretase inhibition by anti-cancer clinical drugs To Be Published
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8KCS
| Cryo-EM structure of human gamma-secretase in complex with BMS906024 | 分子名称: | (2S,3R)-N'-[(3S)-1-methyl-2-oxidanylidene-5-phenyl-3H-1,4-benzodiazepin-3-yl]-2,3-bis[3,3,3-tris(fluoranyl)propyl]butanediamide, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Guo, X, Li, H, Kai, U, Yan, C, Lei, J, Zhou, R, Shi, Y. | 登録日 | 2023-08-08 | 公開日 | 2024-08-14 | 実験手法 | ELECTRON MICROSCOPY (2.4 Å) | 主引用文献 | Structural Basis of gamma-secretase inhibition by anti-cancer clinical drugs To Be Published
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7YI4
| Cryo-EM structure of Rpd3S complex bound to H3K36me3 nucleosome in close state | 分子名称: | Chromatin modification-related protein EAF3, Histone H2A, Histone H2B 1.1, ... | 著者 | Li, H.T, Yan, C.Y, Guan, H.P, Wang, P. | 登録日 | 2022-07-14 | 公開日 | 2023-06-14 | 最終更新日 | 2023-08-30 | 実験手法 | ELECTRON MICROSCOPY (3.96 Å) | 主引用文献 | Diverse modes of H3K36me3-guided nucleosomal deacetylation by Rpd3S. Nature, 620, 2023
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4ITH
| Crystal structure of RIP1 kinase in complex with necrostatin-1 analog | 分子名称: | (5R)-5-[(7-chloro-1H-indol-3-yl)methyl]-3-methylimidazolidine-2,4-dione, IODIDE ION, Receptor-interacting serine/threonine-protein kinase 1, ... | 著者 | Xie, T, Peng, W, Liu, Y, Yan, C, Shi, Y. | 登録日 | 2013-01-18 | 公開日 | 2013-03-13 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Structural Basis of RIP1 Inhibition by Necrostatins. Structure, 21, 2013
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7WSM
| Cryo-EM structure of human glucose transporter GLUT4 bound to cytochalasin B in lipid nanodiscs | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Cytochalasin B, Solute carrier family 2, ... | 著者 | Yuan, Y, Kong, F, Xu, H, Zhu, A, Yan, N, Yan, C. | 登録日 | 2022-01-30 | 公開日 | 2022-05-18 | 最終更新日 | 2022-05-25 | 実験手法 | ELECTRON MICROSCOPY (3.25 Å) | 主引用文献 | Cryo-EM structure of human glucose transporter GLUT4. Nat Commun, 13, 2022
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7WSN
| Cryo-EM structure of human glucose transporter GLUT4 bound to cytochalasin B in detergent micelles | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Cytochalasin B, Solute carrier family 2, ... | 著者 | Yuan, Y, Kong, F, Xu, H, Zhu, A, Yan, N, Yan, C. | 登録日 | 2022-01-30 | 公開日 | 2022-05-18 | 最終更新日 | 2022-05-25 | 実験手法 | ELECTRON MICROSCOPY (3.31 Å) | 主引用文献 | Cryo-EM structure of human glucose transporter GLUT4. Nat Commun, 13, 2022
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4O6Y
| Crystal Structure of Cytochrome b561 | 分子名称: | PROTOPORPHYRIN IX CONTAINING FE, Probable transmembrane ascorbate ferrireductase 2, SULFATE ION | 著者 | Lu, P, Ma, D, Yan, C, Gong, X, Du, M, Shi, Y. | 登録日 | 2013-12-24 | 公開日 | 2014-02-05 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structure and mechanism of a eukaryotic transmembrane ascorbate-dependent oxidoreductase Proc.Natl.Acad.Sci.USA, 111, 2014
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4M67
| Crystal structure of the human MLKL kinase-like domain | 分子名称: | Mixed lineage kinase domain-like protein | 著者 | Xie, T, Peng, W, Yan, C, Wu, J, Shi, Y. | 登録日 | 2013-08-09 | 公開日 | 2013-10-16 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structural Insights into RIP3-Mediated Necroptotic Signaling Cell Rep, 5, 2013
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4EHR
| Crystal structure of Bcl-Xl complex with 4-(5-butyl-3-(hydroxymethyl)-1-phenyl-1h-pyrazol-4-yl)-3-(3,4-dihydro-2(1h)-isoquinolinylcarbonyl)-n-((2-(trimethylsilyl)ethyl)sulfonyl)benzamide | 分子名称: | 4-[5-butyl-3-(hydroxymethyl)-1-phenyl-1H-pyrazol-4-yl]-3-(3,4-dihydroisoquinolin-2(1H)-ylcarbonyl)-N-{[2-(trimethylsilyl)ethyl]sulfonyl}benzamide, Bcl-2-like protein 1, IMIDAZOLE | 著者 | Schroeder, G.M, Wei, D, Banfi, P, Cai, Z, Lippy, J, Menichincheri, M, Modugno, M, Naglich, J, Penhallow, B, Perez, H.L, Sack, J, Schmidt, R.J, Tebben, A, Yan, C, Zhang, L, Galvani, A, Lombardo, L.J, Borzilleri, R.M. | 登録日 | 2012-04-03 | 公開日 | 2012-06-06 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.09 Å) | 主引用文献 | Pyrazole and pyrimidine phenylacylsulfonamides as dual Bcl-2/Bcl-xL antagonists. Bioorg.Med.Chem.Lett., 22, 2012
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4DJI
| Structure of glutamate-GABA antiporter GadC | 分子名称: | Probable glutamate/gamma-aminobutyrate antiporter | 著者 | Ma, D, Lu, P.L, Yan, C.Y, Fan, C, Yin, P, Wang, J.W, Shi, Y.G. | 登録日 | 2012-02-02 | 公開日 | 2012-03-14 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (3.187 Å) | 主引用文献 | Structure and mechanism of a glutamate-GABA antiporter Nature, 483, 2012
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7YMJ
| Cryo-EM structure of alpha1AAR-Nb6 complex bound to tamsulosin | 分子名称: | Nb6, Tamsulosin, alpha1A-adrenergic receptor | 著者 | Toyoda, Y, Zhu, A, Yan, C, Kobilka, B.K, Liu, X. | 登録日 | 2022-07-28 | 公開日 | 2023-07-05 | 最終更新日 | 2024-10-30 | 実験手法 | ELECTRON MICROSCOPY (3.35 Å) | 主引用文献 | Structural basis of alpha 1A -adrenergic receptor activation and recognition by an extracellular nanobody. Nat Commun, 14, 2023
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7YMH
| Cryo-EM structure of Nb29-alpha1AAR-miniGsq complex bound to noradrenaline | 分子名称: | Nb29, Noradrenaline, alpha1A-adrenergic receptor, ... | 著者 | Toyoda, Y, Zhu, A, Yan, C, Kobilka, B.K, Liu, X. | 登録日 | 2022-07-28 | 公開日 | 2023-07-05 | 最終更新日 | 2024-10-09 | 実験手法 | ELECTRON MICROSCOPY (3.52 Å) | 主引用文献 | Structural basis of alpha 1A -adrenergic receptor activation and recognition by an extracellular nanobody. Nat Commun, 14, 2023
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7YM8
| Cryo-EM structure of Nb29-alpha1AAR-miniGsq complex bound to oxymetazoline | 分子名称: | CHOLESTEROL HEMISUCCINATE, Oxymetazoline, alpha1A adrenergic receptor, ... | 著者 | Toyoda, Y, Zhu, A, Yan, C, Kobilka, B.K, Liu, X. | 登録日 | 2022-07-27 | 公開日 | 2023-07-05 | 最終更新日 | 2024-10-23 | 実験手法 | ELECTRON MICROSCOPY (2.92 Å) | 主引用文献 | Structural basis of alpha 1A -adrenergic receptor activation and recognition by an extracellular nanobody. Nat Commun, 14, 2023
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8HFF
| Cryo-EM structure of human norepinephrine transporter NET in the presence of norepinephrine in an inward-open state at resolution of 2.9 angstrom. | 分子名称: | L-NOREPINEPHRINE, Sodium-dependent noradrenaline transporter | 著者 | Tan, J, Xiao, Y, Kong, F, Lei, J, Yuan, Y, Yan, C. | 登録日 | 2022-11-10 | 公開日 | 2024-05-15 | 最終更新日 | 2024-10-23 | 実験手法 | ELECTRON MICROSCOPY (2.86 Å) | 主引用文献 | Molecular basis of human noradrenaline transporter reuptake and inhibition. Nature, 632, 2024
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8HFI
| Cryo-EM structure of human norepinephrine transporter NET in the presence of the antidepressant desipramine in an inward-open state at resolution of 2.5 angstrom. | 分子名称: | 3-(10,11-DIHYDRO-5H-DIBENZO[B,F]AZEPIN-5-YL)-N-METHYLPROPAN-1-AMINE, CHLORIDE ION, Sodium-dependent noradrenaline transporter | 著者 | Tan, J, Xiao, Y, Kong, F, Lei, J, Yuan, Y, Yan, C. | 登録日 | 2022-11-10 | 公開日 | 2024-05-15 | 最終更新日 | 2024-09-04 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | Molecular basis of human noradrenaline transporter reuptake and inhibition. Nature, 632, 2024
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8HFL
| Cryo-EM structure of human norepinephrine transporter NET in the presence of the antidepressant bupropion in an inward-open state at resolution of 3.0 angstrom. | 分子名称: | Bupropion, CHLORIDE ION, Sodium-dependent noradrenaline transporter | 著者 | Tan, J, Xiao, Y, Kong, F, Lei, J, Yuan, Y, Yan, C. | 登録日 | 2022-11-11 | 公開日 | 2024-05-15 | 最終更新日 | 2024-09-04 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Molecular basis of human noradrenaline transporter reuptake and inhibition. Nature, 632, 2024
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8HFG
| Cryo-EM structure of human norepinephrine transporter NET in the presence of dopamine in an inward-open state at resolution of 3.0 angstrom. | 分子名称: | CHLORIDE ION, L-DOPAMINE, Sodium-dependent noradrenaline transporter | 著者 | Tan, J, Xiao, Y, Kong, F, Lei, J, Yuan, Y, Yan, C. | 登録日 | 2022-11-10 | 公開日 | 2024-05-15 | 最終更新日 | 2024-09-04 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Molecular basis of human noradrenaline transporter reuptake and inhibition. Nature, 632, 2024
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8HFE
| Cryo-EM structure of human norepinephrine transporter NET in an inward-open state at resolution of 2.5 angstrom | 分子名称: | CHLORIDE ION, Sodium-dependent noradrenaline transporter | 著者 | Tan, J, Xiao, Y, Kong, F, Lei, J, Yuan, Y, Yan, C. | 登録日 | 2022-11-10 | 公開日 | 2024-05-15 | 最終更新日 | 2024-09-04 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | Molecular basis of human noradrenaline transporter reuptake and inhibition. Nature, 632, 2024
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8I3V
| Cryo-EM structure of human norepinephrine transporter NET in the presence of the antidepressant escitalopram in an inward-open state at resolution of 2.85 angstrom. | 分子名称: | (1S)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile, CHLORIDE ION, Sodium-dependent noradrenaline transporter | 著者 | Tan, J, Xiao, Y, Kong, F, Lei, J, Yuan, Y, Yan, C. | 登録日 | 2023-01-18 | 公開日 | 2024-07-03 | 最終更新日 | 2024-09-04 | 実験手法 | ELECTRON MICROSCOPY (2.85 Å) | 主引用文献 | Molecular basis of human noradrenaline transporter reuptake and inhibition. Nature, 632, 2024
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5IVW
| Human core TFIIH bound to DNA within the PIC | 分子名称: | General transcription factor IIH subunit 2, General transcription factor IIH subunit 3, General transcription factor IIH subunit 4, ... | 著者 | He, Y, Yan, C, Fang, J, Inouye, C, Tjian, R, Ivanov, I, Nogales, E. | 登録日 | 2016-03-21 | 公開日 | 2016-05-18 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (10 Å) | 主引用文献 | Near-atomic resolution visualization of human transcription promoter opening. Nature, 533, 2016
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8WGX
| Cryo-EM structure of inward-open state human norepinephrine transporter NET bound with norepinephrine in nanodisc. | 分子名称: | L-NOREPINEPHRINE, Sodium-dependent noradrenaline transporter | 著者 | Tan, J, Xiao, Y, Kong, F, Lei, J, Yuan, Y, Yan, C. | 登録日 | 2023-09-22 | 公開日 | 2024-07-31 | 最終更新日 | 2024-09-04 | 実験手法 | ELECTRON MICROSCOPY (3.47 Å) | 主引用文献 | Molecular basis of human noradrenaline transporter reuptake and inhibition. Nature, 632, 2024
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8WGR
| Cryo-EM structure of inward-open state human norepinephrine transporter NET bound with antidepressant desipramine in KCl condition. | 分子名称: | 3-(10,11-DIHYDRO-5H-DIBENZO[B,F]AZEPIN-5-YL)-N-METHYLPROPAN-1-AMINE, CHLORIDE ION, POTASSIUM ION, ... | 著者 | Tan, J, Xiao, Y, Kong, F, Lei, J, Yuan, Y, Yan, C. | 登録日 | 2023-09-22 | 公開日 | 2024-07-31 | 最終更新日 | 2024-09-04 | 実験手法 | ELECTRON MICROSCOPY (2.75 Å) | 主引用文献 | Molecular basis of human noradrenaline transporter reuptake and inhibition. Nature, 632, 2024
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1B5A
| RAT FERROCYTOCHROME B5 A CONFORMATION, NMR, 1 STRUCTURE | 分子名称: | FERROCYTOCHROME B5, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Dangi, B, Sarma, S, Yan, C, Banville, D, Guiles, R.D. | 登録日 | 1998-04-06 | 公開日 | 1998-06-17 | 最終更新日 | 2024-04-10 | 実験手法 | SOLUTION NMR | 主引用文献 | The origin of differences in the physical properties of the equilibrium forms of cytochrome b5 revealed through high-resolution NMR structures and backbone dynamic analyses. Biochemistry, 37, 1998
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4M68
| Crystal structure of the mouse MLKL kinase-like domain | 分子名称: | GLYCEROL, Mixed lineage kinase domain-like protein | 著者 | Xie, T, Peng, W, Yan, C, Wu, J, Shi, Y. | 登録日 | 2013-08-09 | 公開日 | 2013-10-16 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.696 Å) | 主引用文献 | Structural Insights into RIP3-Mediated Necroptotic Signaling Cell Rep, 5, 2013
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