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PDB: 573 件

7YI5
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Cryo-EM structure of Rpd3S complex bound to H3K36me3 nucleosome in loose state
分子名称: Chromatin modification-related protein EAF3, Histone H2A, Histone H2B 1.1, ...
著者Li, H.T, Yan, C.Y, Guan, H.P, Wang, P.
登録日2022-07-14
公開日2023-06-14
最終更新日2023-08-30
実験手法ELECTRON MICROSCOPY (3.96 Å)
主引用文献Diverse modes of H3K36me3-guided nucleosomal deacetylation by Rpd3S.
Nature, 620, 2023
8KCT
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Cryo-EM structure of human gamma-secretase in complex with Nirogacestat
分子名称: (2S)-2-[[(2S)-6,8-bis(fluoranyl)-1,2,3,4-tetrahydronaphthalen-2-yl]amino]-N-[1-[1-(2,2-dimethylpropylamino)-2-methyl-propan-2-yl]imidazol-4-yl]pentanamide, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Guo, X, Li, H, Kai, U, Yan, C, Lei, J, Zhou, R, Shi, Y.
登録日2023-08-08
公開日2024-08-14
実験手法ELECTRON MICROSCOPY (2.6 Å)
主引用文献Structural Basis of gamma-secretase inhibition by anti-cancer clinical drugs
To Be Published
8KCS
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Cryo-EM structure of human gamma-secretase in complex with BMS906024
分子名称: (2S,3R)-N'-[(3S)-1-methyl-2-oxidanylidene-5-phenyl-3H-1,4-benzodiazepin-3-yl]-2,3-bis[3,3,3-tris(fluoranyl)propyl]butanediamide, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Guo, X, Li, H, Kai, U, Yan, C, Lei, J, Zhou, R, Shi, Y.
登録日2023-08-08
公開日2024-08-14
実験手法ELECTRON MICROSCOPY (2.4 Å)
主引用文献Structural Basis of gamma-secretase inhibition by anti-cancer clinical drugs
To Be Published
7YI4
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BU of 7yi4 by Molmil
Cryo-EM structure of Rpd3S complex bound to H3K36me3 nucleosome in close state
分子名称: Chromatin modification-related protein EAF3, Histone H2A, Histone H2B 1.1, ...
著者Li, H.T, Yan, C.Y, Guan, H.P, Wang, P.
登録日2022-07-14
公開日2023-06-14
最終更新日2023-08-30
実験手法ELECTRON MICROSCOPY (3.96 Å)
主引用文献Diverse modes of H3K36me3-guided nucleosomal deacetylation by Rpd3S.
Nature, 620, 2023
4ITH
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Crystal structure of RIP1 kinase in complex with necrostatin-1 analog
分子名称: (5R)-5-[(7-chloro-1H-indol-3-yl)methyl]-3-methylimidazolidine-2,4-dione, IODIDE ION, Receptor-interacting serine/threonine-protein kinase 1, ...
著者Xie, T, Peng, W, Liu, Y, Yan, C, Shi, Y.
登録日2013-01-18
公開日2013-03-13
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Structural Basis of RIP1 Inhibition by Necrostatins.
Structure, 21, 2013
7WSM
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Cryo-EM structure of human glucose transporter GLUT4 bound to cytochalasin B in lipid nanodiscs
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Cytochalasin B, Solute carrier family 2, ...
著者Yuan, Y, Kong, F, Xu, H, Zhu, A, Yan, N, Yan, C.
登録日2022-01-30
公開日2022-05-18
最終更新日2022-05-25
実験手法ELECTRON MICROSCOPY (3.25 Å)
主引用文献Cryo-EM structure of human glucose transporter GLUT4.
Nat Commun, 13, 2022
7WSN
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BU of 7wsn by Molmil
Cryo-EM structure of human glucose transporter GLUT4 bound to cytochalasin B in detergent micelles
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Cytochalasin B, Solute carrier family 2, ...
著者Yuan, Y, Kong, F, Xu, H, Zhu, A, Yan, N, Yan, C.
登録日2022-01-30
公開日2022-05-18
最終更新日2022-05-25
実験手法ELECTRON MICROSCOPY (3.31 Å)
主引用文献Cryo-EM structure of human glucose transporter GLUT4.
Nat Commun, 13, 2022
4O6Y
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Crystal Structure of Cytochrome b561
分子名称: PROTOPORPHYRIN IX CONTAINING FE, Probable transmembrane ascorbate ferrireductase 2, SULFATE ION
著者Lu, P, Ma, D, Yan, C, Gong, X, Du, M, Shi, Y.
登録日2013-12-24
公開日2014-02-05
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structure and mechanism of a eukaryotic transmembrane ascorbate-dependent oxidoreductase
Proc.Natl.Acad.Sci.USA, 111, 2014
4M67
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Crystal structure of the human MLKL kinase-like domain
分子名称: Mixed lineage kinase domain-like protein
著者Xie, T, Peng, W, Yan, C, Wu, J, Shi, Y.
登録日2013-08-09
公開日2013-10-16
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural Insights into RIP3-Mediated Necroptotic Signaling
Cell Rep, 5, 2013
4EHR
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BU of 4ehr by Molmil
Crystal structure of Bcl-Xl complex with 4-(5-butyl-3-(hydroxymethyl)-1-phenyl-1h-pyrazol-4-yl)-3-(3,4-dihydro-2(1h)-isoquinolinylcarbonyl)-n-((2-(trimethylsilyl)ethyl)sulfonyl)benzamide
分子名称: 4-[5-butyl-3-(hydroxymethyl)-1-phenyl-1H-pyrazol-4-yl]-3-(3,4-dihydroisoquinolin-2(1H)-ylcarbonyl)-N-{[2-(trimethylsilyl)ethyl]sulfonyl}benzamide, Bcl-2-like protein 1, IMIDAZOLE
著者Schroeder, G.M, Wei, D, Banfi, P, Cai, Z, Lippy, J, Menichincheri, M, Modugno, M, Naglich, J, Penhallow, B, Perez, H.L, Sack, J, Schmidt, R.J, Tebben, A, Yan, C, Zhang, L, Galvani, A, Lombardo, L.J, Borzilleri, R.M.
登録日2012-04-03
公開日2012-06-06
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.09 Å)
主引用文献Pyrazole and pyrimidine phenylacylsulfonamides as dual Bcl-2/Bcl-xL antagonists.
Bioorg.Med.Chem.Lett., 22, 2012
4DJI
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BU of 4dji by Molmil
Structure of glutamate-GABA antiporter GadC
分子名称: Probable glutamate/gamma-aminobutyrate antiporter
著者Ma, D, Lu, P.L, Yan, C.Y, Fan, C, Yin, P, Wang, J.W, Shi, Y.G.
登録日2012-02-02
公開日2012-03-14
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (3.187 Å)
主引用文献Structure and mechanism of a glutamate-GABA antiporter
Nature, 483, 2012
7YMJ
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BU of 7ymj by Molmil
Cryo-EM structure of alpha1AAR-Nb6 complex bound to tamsulosin
分子名称: Nb6, Tamsulosin, alpha1A-adrenergic receptor
著者Toyoda, Y, Zhu, A, Yan, C, Kobilka, B.K, Liu, X.
登録日2022-07-28
公開日2023-07-05
最終更新日2024-10-30
実験手法ELECTRON MICROSCOPY (3.35 Å)
主引用文献Structural basis of alpha 1A -adrenergic receptor activation and recognition by an extracellular nanobody.
Nat Commun, 14, 2023
7YMH
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Cryo-EM structure of Nb29-alpha1AAR-miniGsq complex bound to noradrenaline
分子名称: Nb29, Noradrenaline, alpha1A-adrenergic receptor, ...
著者Toyoda, Y, Zhu, A, Yan, C, Kobilka, B.K, Liu, X.
登録日2022-07-28
公開日2023-07-05
最終更新日2024-10-09
実験手法ELECTRON MICROSCOPY (3.52 Å)
主引用文献Structural basis of alpha 1A -adrenergic receptor activation and recognition by an extracellular nanobody.
Nat Commun, 14, 2023
7YM8
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Cryo-EM structure of Nb29-alpha1AAR-miniGsq complex bound to oxymetazoline
分子名称: CHOLESTEROL HEMISUCCINATE, Oxymetazoline, alpha1A adrenergic receptor, ...
著者Toyoda, Y, Zhu, A, Yan, C, Kobilka, B.K, Liu, X.
登録日2022-07-27
公開日2023-07-05
最終更新日2024-10-23
実験手法ELECTRON MICROSCOPY (2.92 Å)
主引用文献Structural basis of alpha 1A -adrenergic receptor activation and recognition by an extracellular nanobody.
Nat Commun, 14, 2023
8HFF
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BU of 8hff by Molmil
Cryo-EM structure of human norepinephrine transporter NET in the presence of norepinephrine in an inward-open state at resolution of 2.9 angstrom.
分子名称: L-NOREPINEPHRINE, Sodium-dependent noradrenaline transporter
著者Tan, J, Xiao, Y, Kong, F, Lei, J, Yuan, Y, Yan, C.
登録日2022-11-10
公開日2024-05-15
最終更新日2024-10-23
実験手法ELECTRON MICROSCOPY (2.86 Å)
主引用文献Molecular basis of human noradrenaline transporter reuptake and inhibition.
Nature, 632, 2024
8HFI
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Cryo-EM structure of human norepinephrine transporter NET in the presence of the antidepressant desipramine in an inward-open state at resolution of 2.5 angstrom.
分子名称: 3-(10,11-DIHYDRO-5H-DIBENZO[B,F]AZEPIN-5-YL)-N-METHYLPROPAN-1-AMINE, CHLORIDE ION, Sodium-dependent noradrenaline transporter
著者Tan, J, Xiao, Y, Kong, F, Lei, J, Yuan, Y, Yan, C.
登録日2022-11-10
公開日2024-05-15
最終更新日2024-09-04
実験手法ELECTRON MICROSCOPY (2.5 Å)
主引用文献Molecular basis of human noradrenaline transporter reuptake and inhibition.
Nature, 632, 2024
8HFL
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BU of 8hfl by Molmil
Cryo-EM structure of human norepinephrine transporter NET in the presence of the antidepressant bupropion in an inward-open state at resolution of 3.0 angstrom.
分子名称: Bupropion, CHLORIDE ION, Sodium-dependent noradrenaline transporter
著者Tan, J, Xiao, Y, Kong, F, Lei, J, Yuan, Y, Yan, C.
登録日2022-11-11
公開日2024-05-15
最終更新日2024-09-04
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Molecular basis of human noradrenaline transporter reuptake and inhibition.
Nature, 632, 2024
8HFG
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Cryo-EM structure of human norepinephrine transporter NET in the presence of dopamine in an inward-open state at resolution of 3.0 angstrom.
分子名称: CHLORIDE ION, L-DOPAMINE, Sodium-dependent noradrenaline transporter
著者Tan, J, Xiao, Y, Kong, F, Lei, J, Yuan, Y, Yan, C.
登録日2022-11-10
公開日2024-05-15
最終更新日2024-09-04
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Molecular basis of human noradrenaline transporter reuptake and inhibition.
Nature, 632, 2024
8HFE
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BU of 8hfe by Molmil
Cryo-EM structure of human norepinephrine transporter NET in an inward-open state at resolution of 2.5 angstrom
分子名称: CHLORIDE ION, Sodium-dependent noradrenaline transporter
著者Tan, J, Xiao, Y, Kong, F, Lei, J, Yuan, Y, Yan, C.
登録日2022-11-10
公開日2024-05-15
最終更新日2024-09-04
実験手法ELECTRON MICROSCOPY (2.5 Å)
主引用文献Molecular basis of human noradrenaline transporter reuptake and inhibition.
Nature, 632, 2024
8I3V
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BU of 8i3v by Molmil
Cryo-EM structure of human norepinephrine transporter NET in the presence of the antidepressant escitalopram in an inward-open state at resolution of 2.85 angstrom.
分子名称: (1S)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile, CHLORIDE ION, Sodium-dependent noradrenaline transporter
著者Tan, J, Xiao, Y, Kong, F, Lei, J, Yuan, Y, Yan, C.
登録日2023-01-18
公開日2024-07-03
最終更新日2024-09-04
実験手法ELECTRON MICROSCOPY (2.85 Å)
主引用文献Molecular basis of human noradrenaline transporter reuptake and inhibition.
Nature, 632, 2024
5IVW
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Human core TFIIH bound to DNA within the PIC
分子名称: General transcription factor IIH subunit 2, General transcription factor IIH subunit 3, General transcription factor IIH subunit 4, ...
著者He, Y, Yan, C, Fang, J, Inouye, C, Tjian, R, Ivanov, I, Nogales, E.
登録日2016-03-21
公開日2016-05-18
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (10 Å)
主引用文献Near-atomic resolution visualization of human transcription promoter opening.
Nature, 533, 2016
8WGX
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BU of 8wgx by Molmil
Cryo-EM structure of inward-open state human norepinephrine transporter NET bound with norepinephrine in nanodisc.
分子名称: L-NOREPINEPHRINE, Sodium-dependent noradrenaline transporter
著者Tan, J, Xiao, Y, Kong, F, Lei, J, Yuan, Y, Yan, C.
登録日2023-09-22
公開日2024-07-31
最終更新日2024-09-04
実験手法ELECTRON MICROSCOPY (3.47 Å)
主引用文献Molecular basis of human noradrenaline transporter reuptake and inhibition.
Nature, 632, 2024
8WGR
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Cryo-EM structure of inward-open state human norepinephrine transporter NET bound with antidepressant desipramine in KCl condition.
分子名称: 3-(10,11-DIHYDRO-5H-DIBENZO[B,F]AZEPIN-5-YL)-N-METHYLPROPAN-1-AMINE, CHLORIDE ION, POTASSIUM ION, ...
著者Tan, J, Xiao, Y, Kong, F, Lei, J, Yuan, Y, Yan, C.
登録日2023-09-22
公開日2024-07-31
最終更新日2024-09-04
実験手法ELECTRON MICROSCOPY (2.75 Å)
主引用文献Molecular basis of human noradrenaline transporter reuptake and inhibition.
Nature, 632, 2024
1B5A
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RAT FERROCYTOCHROME B5 A CONFORMATION, NMR, 1 STRUCTURE
分子名称: FERROCYTOCHROME B5, PROTOPORPHYRIN IX CONTAINING FE
著者Dangi, B, Sarma, S, Yan, C, Banville, D, Guiles, R.D.
登録日1998-04-06
公開日1998-06-17
最終更新日2024-04-10
実験手法SOLUTION NMR
主引用文献The origin of differences in the physical properties of the equilibrium forms of cytochrome b5 revealed through high-resolution NMR structures and backbone dynamic analyses.
Biochemistry, 37, 1998
4M68
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Crystal structure of the mouse MLKL kinase-like domain
分子名称: GLYCEROL, Mixed lineage kinase domain-like protein
著者Xie, T, Peng, W, Yan, C, Wu, J, Shi, Y.
登録日2013-08-09
公開日2013-10-16
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.696 Å)
主引用文献Structural Insights into RIP3-Mediated Necroptotic Signaling
Cell Rep, 5, 2013

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